Effect of Remimazolam and Propofol on Blood Glucose and Serum Inflammatory Markers in Patients with Type 2 Diabetes: A Clinical Trial with Prospective Randomized Control
<i>Background and Objectives:</i> Patients with type 2 diabetes are at a higher risk of postoperative complications, such as infections, delayed wound healing, and increased mortality compared to non-diabetic patients. <i>Materials and Methods:</i> This prospective randomized...
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MDPI AG
2025-03-01
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| author | Sang Hun Kim Sang Min Yoon Ji Hye Ahn Yoon Ji Choi |
| author_facet | Sang Hun Kim Sang Min Yoon Ji Hye Ahn Yoon Ji Choi |
| author_sort | Sang Hun Kim |
| collection | DOAJ |
| description | <i>Background and Objectives:</i> Patients with type 2 diabetes are at a higher risk of postoperative complications, such as infections, delayed wound healing, and increased mortality compared to non-diabetic patients. <i>Materials and Methods:</i> This prospective randomized study aims to compare the effects of two anesthetics, remimazolam and propofol, on blood glucose levels and immune function in diabetic patients undergoing surgery. Seventy-four diabetic patients undergoing general anesthesia were randomly assigned to receive either remimazolam or propofol. Plasma blood glucose levels, anti-inflammatory markers, and insulin levels were measured during the perioperative period. <i>Results:</i> No statistically significant differences were observed between the remimazolam and propofol groups in terms of neutrophil-to-lymphocyte ratio, anti-inflammatory markers, or glucose levels during the perioperative period (<i>p</i> value > 0.05). <i>Conclusions:</i> These results suggest that there is no difference between propofol and remimazolam in immune function deterioration that occurs due to surgical stress. This study is limited by its small sample size, and in future, larger trials could be conducted to find differences in the effects of blood sugar levels and serum inflammatory markers between the two groups. |
| format | Article |
| id | doaj-art-e2feac06e649446fa84f57d2d4110612 |
| institution | OA Journals |
| issn | 1010-660X 1648-9144 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | MDPI AG |
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| series | Medicina |
| spelling | doaj-art-e2feac06e649446fa84f57d2d41106122025-08-20T02:11:04ZengMDPI AGMedicina1010-660X1648-91442025-03-0161352310.3390/medicina61030523Effect of Remimazolam and Propofol on Blood Glucose and Serum Inflammatory Markers in Patients with Type 2 Diabetes: A Clinical Trial with Prospective Randomized ControlSang Hun Kim0Sang Min Yoon1Ji Hye Ahn2Yoon Ji Choi3Department of Anesthesiology and Pain Medicine, College of Medicine, Chosun University, Gwangju 61453, Republic of KoreaDepartment of Anesthesiology and Pain Medicine, Korea University Ansan Hospital, Korea University College of Medicine, Ansan 15355, Republic of KoreaDepartment of Anesthesiology, Donghoon Advanced Lengthening Reconstruction Institute, Seongnam 13647, Republic of KoreaDepartment of Anesthesiology and Pain Medicine, Korea University Ansan Hospital, Korea University College of Medicine, Ansan 15355, Republic of Korea<i>Background and Objectives:</i> Patients with type 2 diabetes are at a higher risk of postoperative complications, such as infections, delayed wound healing, and increased mortality compared to non-diabetic patients. <i>Materials and Methods:</i> This prospective randomized study aims to compare the effects of two anesthetics, remimazolam and propofol, on blood glucose levels and immune function in diabetic patients undergoing surgery. Seventy-four diabetic patients undergoing general anesthesia were randomly assigned to receive either remimazolam or propofol. Plasma blood glucose levels, anti-inflammatory markers, and insulin levels were measured during the perioperative period. <i>Results:</i> No statistically significant differences were observed between the remimazolam and propofol groups in terms of neutrophil-to-lymphocyte ratio, anti-inflammatory markers, or glucose levels during the perioperative period (<i>p</i> value > 0.05). <i>Conclusions:</i> These results suggest that there is no difference between propofol and remimazolam in immune function deterioration that occurs due to surgical stress. This study is limited by its small sample size, and in future, larger trials could be conducted to find differences in the effects of blood sugar levels and serum inflammatory markers between the two groups.https://www.mdpi.com/1648-9144/61/3/523anti-inflammatory markersblood sugarglucoseinsulinpropofolremimazolam |
| spellingShingle | Sang Hun Kim Sang Min Yoon Ji Hye Ahn Yoon Ji Choi Effect of Remimazolam and Propofol on Blood Glucose and Serum Inflammatory Markers in Patients with Type 2 Diabetes: A Clinical Trial with Prospective Randomized Control Medicina anti-inflammatory markers blood sugar glucose insulin propofol remimazolam |
| title | Effect of Remimazolam and Propofol on Blood Glucose and Serum Inflammatory Markers in Patients with Type 2 Diabetes: A Clinical Trial with Prospective Randomized Control |
| title_full | Effect of Remimazolam and Propofol on Blood Glucose and Serum Inflammatory Markers in Patients with Type 2 Diabetes: A Clinical Trial with Prospective Randomized Control |
| title_fullStr | Effect of Remimazolam and Propofol on Blood Glucose and Serum Inflammatory Markers in Patients with Type 2 Diabetes: A Clinical Trial with Prospective Randomized Control |
| title_full_unstemmed | Effect of Remimazolam and Propofol on Blood Glucose and Serum Inflammatory Markers in Patients with Type 2 Diabetes: A Clinical Trial with Prospective Randomized Control |
| title_short | Effect of Remimazolam and Propofol on Blood Glucose and Serum Inflammatory Markers in Patients with Type 2 Diabetes: A Clinical Trial with Prospective Randomized Control |
| title_sort | effect of remimazolam and propofol on blood glucose and serum inflammatory markers in patients with type 2 diabetes a clinical trial with prospective randomized control |
| topic | anti-inflammatory markers blood sugar glucose insulin propofol remimazolam |
| url | https://www.mdpi.com/1648-9144/61/3/523 |
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