HSP70 and TNF Loci Polymorphism Associated with the Posner-Schlossman Syndrome in a Southern Chinese Population
Previous studies have shown that HLA gene polymorphisms are associated with the pathogenesis of the Posner-Schlossman syndrome (PSS). This study was aimed at evaluating the associations between HLA-III gene polymorphisms and PSS in a southern Chinese Han population. A total of 150 PSS patients and 1...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2022/5242948 |
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| author | Wei Bai Xiaosheng Huang Xiaoli Shen Ye Ye Shiming Peng Tianhui Zhu Shaoyi Mei Jiajie Kuang Sejie Yu Xiaochen Ma Jun Zhao |
| author_facet | Wei Bai Xiaosheng Huang Xiaoli Shen Ye Ye Shiming Peng Tianhui Zhu Shaoyi Mei Jiajie Kuang Sejie Yu Xiaochen Ma Jun Zhao |
| author_sort | Wei Bai |
| collection | DOAJ |
| description | Previous studies have shown that HLA gene polymorphisms are associated with the pathogenesis of the Posner-Schlossman syndrome (PSS). This study was aimed at evaluating the associations between HLA-III gene polymorphisms and PSS in a southern Chinese Han population. A total of 150 PSS patients and 183 healthy controls were included in this study. Twenty-one single nucleotide polymorphisms (SNPs) of HLA-III genes (including HSP70-1, HSP70-2, HSP70-hom, TNF-α, TNF-β, C2, and CFB) were genotyped using the SNaPshot technique. Our study showed that the frequencies of G allele at rs909253, A allele at rs1041981, and G allele at rs2844484 of TNF-β in the patient group were significantly higher than those in healthy controls (Corrected P Pc=0.040, OR=1.45; Pc=0.033, OR=1.45; Pc=0.045, OR=1.58, respectively). The frequency of T allele at rs12190359 of HSP70-1 was significantly lower in PSS patients than those in healthy controls (Pc=0.018 and OR=0.10). The frequencies of the CCT haplotype of HSP70-1 gene (rs1008438-rs562047-rs12190359) and the ACCCTTT haplotype of HSP70 gene (rs2227956-rs1043618-rs1008438-rs562047-rs12190359-rs2763979-rs6457452) were significantly lower in PSS patients than those in healthy controls (Pc=0.024, OR=0.10; Pc=0.048, OR=0.10, respectively). In conclusion, the G allele at rs909253, A allele at rs1041981, and G allele at rs2844484 of TNF-β gene might be risk factors for PSS, while the T allele at rs12190359 of HSP70-1 gene and specific haplotypes of the HSP70-1 and HSP70 genes might be protective factors for PSS. |
| format | Article |
| id | doaj-art-e2fda06fce4c46138457087757c1d32e |
| institution | DOAJ |
| issn | 2314-7156 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-e2fda06fce4c46138457087757c1d32e2025-08-20T03:21:07ZengWileyJournal of Immunology Research2314-71562022-01-01202210.1155/2022/5242948HSP70 and TNF Loci Polymorphism Associated with the Posner-Schlossman Syndrome in a Southern Chinese PopulationWei Bai0Xiaosheng Huang1Xiaoli Shen2Ye Ye3Shiming Peng4Tianhui Zhu5Shaoyi Mei6Jiajie Kuang7Sejie Yu8Xiaochen Ma9Jun Zhao10The Second Clinical Medical CollegeShenzhen Eye InstituteShenzhen Eye InstituteShenzhen Eye InstituteShenzhen Eye InstituteShenzhen Eye InstituteShenzhen Eye InstituteThe Second Clinical Medical CollegeThe Second Clinical Medical CollegeThe Second Clinical Medical CollegeDepartment of OphthalmologyPrevious studies have shown that HLA gene polymorphisms are associated with the pathogenesis of the Posner-Schlossman syndrome (PSS). This study was aimed at evaluating the associations between HLA-III gene polymorphisms and PSS in a southern Chinese Han population. A total of 150 PSS patients and 183 healthy controls were included in this study. Twenty-one single nucleotide polymorphisms (SNPs) of HLA-III genes (including HSP70-1, HSP70-2, HSP70-hom, TNF-α, TNF-β, C2, and CFB) were genotyped using the SNaPshot technique. Our study showed that the frequencies of G allele at rs909253, A allele at rs1041981, and G allele at rs2844484 of TNF-β in the patient group were significantly higher than those in healthy controls (Corrected P Pc=0.040, OR=1.45; Pc=0.033, OR=1.45; Pc=0.045, OR=1.58, respectively). The frequency of T allele at rs12190359 of HSP70-1 was significantly lower in PSS patients than those in healthy controls (Pc=0.018 and OR=0.10). The frequencies of the CCT haplotype of HSP70-1 gene (rs1008438-rs562047-rs12190359) and the ACCCTTT haplotype of HSP70 gene (rs2227956-rs1043618-rs1008438-rs562047-rs12190359-rs2763979-rs6457452) were significantly lower in PSS patients than those in healthy controls (Pc=0.024, OR=0.10; Pc=0.048, OR=0.10, respectively). In conclusion, the G allele at rs909253, A allele at rs1041981, and G allele at rs2844484 of TNF-β gene might be risk factors for PSS, while the T allele at rs12190359 of HSP70-1 gene and specific haplotypes of the HSP70-1 and HSP70 genes might be protective factors for PSS.http://dx.doi.org/10.1155/2022/5242948 |
| spellingShingle | Wei Bai Xiaosheng Huang Xiaoli Shen Ye Ye Shiming Peng Tianhui Zhu Shaoyi Mei Jiajie Kuang Sejie Yu Xiaochen Ma Jun Zhao HSP70 and TNF Loci Polymorphism Associated with the Posner-Schlossman Syndrome in a Southern Chinese Population Journal of Immunology Research |
| title | HSP70 and TNF Loci Polymorphism Associated with the Posner-Schlossman Syndrome in a Southern Chinese Population |
| title_full | HSP70 and TNF Loci Polymorphism Associated with the Posner-Schlossman Syndrome in a Southern Chinese Population |
| title_fullStr | HSP70 and TNF Loci Polymorphism Associated with the Posner-Schlossman Syndrome in a Southern Chinese Population |
| title_full_unstemmed | HSP70 and TNF Loci Polymorphism Associated with the Posner-Schlossman Syndrome in a Southern Chinese Population |
| title_short | HSP70 and TNF Loci Polymorphism Associated with the Posner-Schlossman Syndrome in a Southern Chinese Population |
| title_sort | hsp70 and tnf loci polymorphism associated with the posner schlossman syndrome in a southern chinese population |
| url | http://dx.doi.org/10.1155/2022/5242948 |
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