Impairment of neuronal activity in the dorsolateral prefrontal cortex occurs early in parkinsonism
BackgroundParkinson’s disease (PD) is often characterized by altered rates and patterns of neuronal activity in the sensorimotor regions of the basal ganglia thalamocortical network. Little is known, however, regarding how neuronal activity in the executive control network of the brain changes in th...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2025.1521443/full |
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| author | Noah Hjelle Biswaranjan Mohanty Tanner Hubbard Matthew D. Johnson Jing Wang Luke A. Johnson Jerrold L. Vitek |
| author_facet | Noah Hjelle Biswaranjan Mohanty Tanner Hubbard Matthew D. Johnson Jing Wang Luke A. Johnson Jerrold L. Vitek |
| author_sort | Noah Hjelle |
| collection | DOAJ |
| description | BackgroundParkinson’s disease (PD) is often characterized by altered rates and patterns of neuronal activity in the sensorimotor regions of the basal ganglia thalamocortical network. Little is known, however, regarding how neuronal activity in the executive control network of the brain changes in the parkinsonian condition.ObjectiveInvestigate the impact of parkinsonism on neuronal activity in the dorsolateral prefrontal cortex (DLPFC), a key region in executive control, during a go/nogo reaching task.MethodsUsing a within-subject design, single and multi-unit neuronal activity was recorded in the DLPFC of a nonhuman primate (n = 1) before and after the induction of mild parkinsonism using the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).ResultsCoincident with development of mild parkinsonian motor signs, there was a marked reduction in the percentage of DLPFC cells with significant task-related firing rate modulation during go and nogo conditions.ConclusionThese results suggest that DLPFC dysfunction may occur early in parkinsonism and contribute to cognitive impairments and disrupted executive function often observed in PD patients. |
| format | Article |
| id | doaj-art-e2fb0afdc74e4492bf68ac592a741ff5 |
| institution | Kabale University |
| issn | 1662-453X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj-art-e2fb0afdc74e4492bf68ac592a741ff52025-01-17T06:50:47ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2025-01-011910.3389/fnins.2025.15214431521443Impairment of neuronal activity in the dorsolateral prefrontal cortex occurs early in parkinsonismNoah Hjelle0Biswaranjan Mohanty1Tanner Hubbard2Matthew D. Johnson3Jing Wang4Luke A. Johnson5Jerrold L. Vitek6Department of Neurology, University of Minnesota, Minneapolis, MN, United StatesDepartment of Neurology, University of Minnesota, Minneapolis, MN, United StatesDepartment of Neurology, University of Minnesota, Minneapolis, MN, United StatesDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, MN, United StatesDepartment of Neurology, University of Minnesota, Minneapolis, MN, United StatesDepartment of Neurology, University of Minnesota, Minneapolis, MN, United StatesDepartment of Neurology, University of Minnesota, Minneapolis, MN, United StatesBackgroundParkinson’s disease (PD) is often characterized by altered rates and patterns of neuronal activity in the sensorimotor regions of the basal ganglia thalamocortical network. Little is known, however, regarding how neuronal activity in the executive control network of the brain changes in the parkinsonian condition.ObjectiveInvestigate the impact of parkinsonism on neuronal activity in the dorsolateral prefrontal cortex (DLPFC), a key region in executive control, during a go/nogo reaching task.MethodsUsing a within-subject design, single and multi-unit neuronal activity was recorded in the DLPFC of a nonhuman primate (n = 1) before and after the induction of mild parkinsonism using the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).ResultsCoincident with development of mild parkinsonian motor signs, there was a marked reduction in the percentage of DLPFC cells with significant task-related firing rate modulation during go and nogo conditions.ConclusionThese results suggest that DLPFC dysfunction may occur early in parkinsonism and contribute to cognitive impairments and disrupted executive function often observed in PD patients.https://www.frontiersin.org/articles/10.3389/fnins.2025.1521443/fullParkinson’s diseaserhesus macaquedorsolateral prefrontal cortexgo/nogoMPTP |
| spellingShingle | Noah Hjelle Biswaranjan Mohanty Tanner Hubbard Matthew D. Johnson Jing Wang Luke A. Johnson Jerrold L. Vitek Impairment of neuronal activity in the dorsolateral prefrontal cortex occurs early in parkinsonism Frontiers in Neuroscience Parkinson’s disease rhesus macaque dorsolateral prefrontal cortex go/nogo MPTP |
| title | Impairment of neuronal activity in the dorsolateral prefrontal cortex occurs early in parkinsonism |
| title_full | Impairment of neuronal activity in the dorsolateral prefrontal cortex occurs early in parkinsonism |
| title_fullStr | Impairment of neuronal activity in the dorsolateral prefrontal cortex occurs early in parkinsonism |
| title_full_unstemmed | Impairment of neuronal activity in the dorsolateral prefrontal cortex occurs early in parkinsonism |
| title_short | Impairment of neuronal activity in the dorsolateral prefrontal cortex occurs early in parkinsonism |
| title_sort | impairment of neuronal activity in the dorsolateral prefrontal cortex occurs early in parkinsonism |
| topic | Parkinson’s disease rhesus macaque dorsolateral prefrontal cortex go/nogo MPTP |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2025.1521443/full |
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