Experimental Study On The Development Of Tolerance And Withdrawal Syndrome To Pentylenetetrazole-Induced Seizures In Rats Treated With Retigabine
The aim of the study was to evaluate seizure liability in rats against the convulsant pentylenetetrazole (PTZ) during a 14-day treatment with retigabine (RTG). The seizure liability was also studied on the 1st, 2nd and 3rd day after the abrupt determination of its administration. Male Wistar rats we...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Medical University - Pleven
2015-06-01
|
| Series: | Journal of Biomedical & Clinical Research |
| Subjects: | |
| Online Access: | https://jbcr.arphahub.com/article/34360/download/pdf/ |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850068409554829312 |
|---|---|
| author | Elisaveta Apostolova Vesela Kokova Lyudmil Peychev |
| author_facet | Elisaveta Apostolova Vesela Kokova Lyudmil Peychev |
| author_sort | Elisaveta Apostolova |
| collection | DOAJ |
| description | The aim of the study was to evaluate seizure liability in rats against the convulsant pentylenetetrazole (PTZ) during a 14-day treatment with retigabine (RTG). The seizure liability was also studied on the 1st, 2nd and 3rd day after the abrupt determination of its administration. Male Wistar rats were divided in groups of 10 and treated orally for 14 days (1st – 6th group with distilled water, and 7th – 12th group with retigabine (RTG) at a dose of 60 mg/kg bw The tolerance to the anticonvulsant effect of RTG was studied using subcutaneous injection of PTZ (120 mg/kg bw) on the 1th and 14th day. To determine the possible neuronal hyperexcitability on the 1st, 2nd and 3rd day after termination of drug administration, a lower dose of PTZ (65 mg/kg bw) was used. According to our results there was no change in the anticonvulsant activity of RTG during the whole period of treatment. The study on withdrawal syndrome showed slightly decrease of the effect on the first day after the last treatment, but with no significant difference to the controls. The anticonvulsant effect of RTG on the 2nd and 3rd day was close to that in the control group. Our results showed no development of tolerance on subchronic treatment with RTG. There was no significant change in the neuronal hyperexcitability on the 1st, 2nd and 3rd day after the termination of treatment. Based on these results we can suggest that RTG has no potential to develop withdrawal syndrome. |
| format | Article |
| id | doaj-art-e2f78b2206b94def95384615d2c8b992 |
| institution | DOAJ |
| issn | 1313-9053 |
| language | English |
| publishDate | 2015-06-01 |
| publisher | Medical University - Pleven |
| record_format | Article |
| series | Journal of Biomedical & Clinical Research |
| spelling | doaj-art-e2f78b2206b94def95384615d2c8b9922025-08-20T02:48:05ZengMedical University - PlevenJournal of Biomedical & Clinical Research1313-90532015-06-018191210.1515/jbcr-2015-014434360Experimental Study On The Development Of Tolerance And Withdrawal Syndrome To Pentylenetetrazole-Induced Seizures In Rats Treated With RetigabineElisaveta ApostolovaVesela KokovaLyudmil PeychevThe aim of the study was to evaluate seizure liability in rats against the convulsant pentylenetetrazole (PTZ) during a 14-day treatment with retigabine (RTG). The seizure liability was also studied on the 1st, 2nd and 3rd day after the abrupt determination of its administration. Male Wistar rats were divided in groups of 10 and treated orally for 14 days (1st – 6th group with distilled water, and 7th – 12th group with retigabine (RTG) at a dose of 60 mg/kg bw The tolerance to the anticonvulsant effect of RTG was studied using subcutaneous injection of PTZ (120 mg/kg bw) on the 1th and 14th day. To determine the possible neuronal hyperexcitability on the 1st, 2nd and 3rd day after termination of drug administration, a lower dose of PTZ (65 mg/kg bw) was used. According to our results there was no change in the anticonvulsant activity of RTG during the whole period of treatment. The study on withdrawal syndrome showed slightly decrease of the effect on the first day after the last treatment, but with no significant difference to the controls. The anticonvulsant effect of RTG on the 2nd and 3rd day was close to that in the control group. Our results showed no development of tolerance on subchronic treatment with RTG. There was no significant change in the neuronal hyperexcitability on the 1st, 2nd and 3rd day after the termination of treatment. Based on these results we can suggest that RTG has no potential to develop withdrawal syndrome.https://jbcr.arphahub.com/article/34360/download/pdf/retigabinetolerancewithdrawalPTZrats |
| spellingShingle | Elisaveta Apostolova Vesela Kokova Lyudmil Peychev Experimental Study On The Development Of Tolerance And Withdrawal Syndrome To Pentylenetetrazole-Induced Seizures In Rats Treated With Retigabine Journal of Biomedical & Clinical Research retigabine tolerance withdrawal PTZ rats |
| title | Experimental Study On The Development Of Tolerance And Withdrawal Syndrome To Pentylenetetrazole-Induced Seizures In Rats Treated With Retigabine |
| title_full | Experimental Study On The Development Of Tolerance And Withdrawal Syndrome To Pentylenetetrazole-Induced Seizures In Rats Treated With Retigabine |
| title_fullStr | Experimental Study On The Development Of Tolerance And Withdrawal Syndrome To Pentylenetetrazole-Induced Seizures In Rats Treated With Retigabine |
| title_full_unstemmed | Experimental Study On The Development Of Tolerance And Withdrawal Syndrome To Pentylenetetrazole-Induced Seizures In Rats Treated With Retigabine |
| title_short | Experimental Study On The Development Of Tolerance And Withdrawal Syndrome To Pentylenetetrazole-Induced Seizures In Rats Treated With Retigabine |
| title_sort | experimental study on the development of tolerance and withdrawal syndrome to pentylenetetrazole induced seizures in rats treated with retigabine |
| topic | retigabine tolerance withdrawal PTZ rats |
| url | https://jbcr.arphahub.com/article/34360/download/pdf/ |
| work_keys_str_mv | AT elisavetaapostolova experimentalstudyonthedevelopmentoftoleranceandwithdrawalsyndrometopentylenetetrazoleinducedseizuresinratstreatedwithretigabine AT veselakokova experimentalstudyonthedevelopmentoftoleranceandwithdrawalsyndrometopentylenetetrazoleinducedseizuresinratstreatedwithretigabine AT lyudmilpeychev experimentalstudyonthedevelopmentoftoleranceandwithdrawalsyndrometopentylenetetrazoleinducedseizuresinratstreatedwithretigabine |