The Emergence of HIV-1 Transmitted Drug Resistance Mutations Among Antiretroviral Therapy-naive Individuals in Buleleng, Bali, Indonesia
Background: the global scale-up of antiretroviral therapy (ART) is the primary factor contributing to the decline in deaths from acquired immune deficiency syndrome (AIDS)-related illnesses. However, the emergence of transmitted drug resistance (TDR) compromises the effects of ART in treatment-naïve...
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| Format: | Article |
| Language: | English |
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Interna Publishing
2019-11-01
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| Series: | Acta Medica Indonesiana |
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| Online Access: | https://www.actamedindones.org/index.php/ijim/article/view/1149 |
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| author | Ni Luh Ayu Megasari Devi Oktafiani Elsa Fitriana Siti Qamariyah Khairunisa Tomohiro Kotaki Shuhei Ueda Nasronudin Nasronudin Soetjipto Soetjipto Masanori Kameoka |
| author_facet | Ni Luh Ayu Megasari Devi Oktafiani Elsa Fitriana Siti Qamariyah Khairunisa Tomohiro Kotaki Shuhei Ueda Nasronudin Nasronudin Soetjipto Soetjipto Masanori Kameoka |
| author_sort | Ni Luh Ayu Megasari |
| collection | DOAJ |
| description | Background: the global scale-up of antiretroviral therapy (ART) is the primary factor contributing to the decline in deaths from acquired immune deficiency syndrome (AIDS)-related illnesses. However, the emergence of transmitted drug resistance (TDR) compromises the effects of ART in treatment-naïve individuals, which may hinder treatment success. The present study aimed to identify the presence of TDR among treatment-naive individuals in Buleleng, Bali, which is currently ranked sixth among Indonesian provinces with the highest cumulative human immunodeficiency virus type 1 (HIV-1) infection cases. Methods: thirty-nine ART-naive individuals in Buleleng Regency General Hospital were enrolled in the present study. Blood samples from participants were subjected to a genotypic analysis. Results: 28 protease (PR) and 30 reverse transcriptase (RT) genes were successfully amplified and sequenced from 37 samples. HIV-1 subtyping revealed CRF01_AE as the dominant circulating recombinant form in the region. No TDR for PR inhibitors was detected; however, TDR for RT inhibitors was identified in five out of 30 samples (16.7%). Conclusion: these results indicate the emergence of TDR among ART-naive individuals in Buleleng, Bali. This issue warrants serious consideration because TDR may hamper treatment success and reduce ART efficacy among newly diagnosed individuals. Continuous surveillance with a larger sample size is necessary to monitor TDR among ART-naive individuals. |
| format | Article |
| id | doaj-art-e2efff7188d24d5f9c7d2fd6eaf0fac7 |
| institution | Kabale University |
| issn | 0125-9326 2338-2732 |
| language | English |
| publishDate | 2019-11-01 |
| publisher | Interna Publishing |
| record_format | Article |
| series | Acta Medica Indonesiana |
| spelling | doaj-art-e2efff7188d24d5f9c7d2fd6eaf0fac72025-08-20T03:26:03ZengInterna PublishingActa Medica Indonesiana0125-93262338-27322019-11-01513The Emergence of HIV-1 Transmitted Drug Resistance Mutations Among Antiretroviral Therapy-naive Individuals in Buleleng, Bali, IndonesiaNi Luh Ayu Megasari0Devi Oktafiani1Elsa Fitriana2Siti Qamariyah Khairunisa3Tomohiro Kotaki4Shuhei Ueda5Nasronudin Nasronudin6Soetjipto Soetjipto7Masanori Kameoka8Universitas AirlanggaUniversitas AirlanggaUniversitas AirlanggaUniversitas AirlanggaKobe University Graduate School of Health SciencesKobe University Graduate School of Health SciencesUniversitas Airlanggasoetjiptojtbr@sby.centrin.net.idDepartment of Public Health, Kobe University Graduate School of Health Sciences, Hyogo, Japan Center for Infectious Diseases, Kobe University Graduate School of Medicine, Hyogo, Japan.Background: the global scale-up of antiretroviral therapy (ART) is the primary factor contributing to the decline in deaths from acquired immune deficiency syndrome (AIDS)-related illnesses. However, the emergence of transmitted drug resistance (TDR) compromises the effects of ART in treatment-naïve individuals, which may hinder treatment success. The present study aimed to identify the presence of TDR among treatment-naive individuals in Buleleng, Bali, which is currently ranked sixth among Indonesian provinces with the highest cumulative human immunodeficiency virus type 1 (HIV-1) infection cases. Methods: thirty-nine ART-naive individuals in Buleleng Regency General Hospital were enrolled in the present study. Blood samples from participants were subjected to a genotypic analysis. Results: 28 protease (PR) and 30 reverse transcriptase (RT) genes were successfully amplified and sequenced from 37 samples. HIV-1 subtyping revealed CRF01_AE as the dominant circulating recombinant form in the region. No TDR for PR inhibitors was detected; however, TDR for RT inhibitors was identified in five out of 30 samples (16.7%). Conclusion: these results indicate the emergence of TDR among ART-naive individuals in Buleleng, Bali. This issue warrants serious consideration because TDR may hamper treatment success and reduce ART efficacy among newly diagnosed individuals. Continuous surveillance with a larger sample size is necessary to monitor TDR among ART-naive individuals.https://www.actamedindones.org/index.php/ijim/article/view/1149HIV-1CRF01_AEBaliantiretroviral therapy (ART)transmitted drug resistance (TDR) |
| spellingShingle | Ni Luh Ayu Megasari Devi Oktafiani Elsa Fitriana Siti Qamariyah Khairunisa Tomohiro Kotaki Shuhei Ueda Nasronudin Nasronudin Soetjipto Soetjipto Masanori Kameoka The Emergence of HIV-1 Transmitted Drug Resistance Mutations Among Antiretroviral Therapy-naive Individuals in Buleleng, Bali, Indonesia Acta Medica Indonesiana HIV-1 CRF01_AE Bali antiretroviral therapy (ART) transmitted drug resistance (TDR) |
| title | The Emergence of HIV-1 Transmitted Drug Resistance Mutations Among Antiretroviral Therapy-naive Individuals in Buleleng, Bali, Indonesia |
| title_full | The Emergence of HIV-1 Transmitted Drug Resistance Mutations Among Antiretroviral Therapy-naive Individuals in Buleleng, Bali, Indonesia |
| title_fullStr | The Emergence of HIV-1 Transmitted Drug Resistance Mutations Among Antiretroviral Therapy-naive Individuals in Buleleng, Bali, Indonesia |
| title_full_unstemmed | The Emergence of HIV-1 Transmitted Drug Resistance Mutations Among Antiretroviral Therapy-naive Individuals in Buleleng, Bali, Indonesia |
| title_short | The Emergence of HIV-1 Transmitted Drug Resistance Mutations Among Antiretroviral Therapy-naive Individuals in Buleleng, Bali, Indonesia |
| title_sort | emergence of hiv 1 transmitted drug resistance mutations among antiretroviral therapy naive individuals in buleleng bali indonesia |
| topic | HIV-1 CRF01_AE Bali antiretroviral therapy (ART) transmitted drug resistance (TDR) |
| url | https://www.actamedindones.org/index.php/ijim/article/view/1149 |
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