L-Phenylalanine promotes liver steatosis by inhibiting BNIP3-mediated mitophagy

L-Phenylalanine promotes liver steatosis by inhibiting BNIP3-mediated mitophagy

Abstract Background L-Phenylalanine (L-Phe) levels are elevated in patients with metabolic dysfunction-associated steatotic liver disease (MASLD). However, whether L-Phe induces liver steatosis and the underlying mechanism remain unknown. This study aimed to investigate the mechanism through which L...

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Main Authors: Ying Sun, Lingli Cai, Bowei Yu, Haojie Zhang, Ziteng Zhang, Xiaoqin Xu, Yuefeng Yu, Jiang Li, Chi Chen, Fangzhen Xia, Yingli Lu, Kun Zhang, Ningjian Wang
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Molecular Medicine
Subjects:
Liver steatosis
L-Phenylalanine
Mitophagy
BNIP3
Online Access:https://doi.org/10.1186/s10020-025-01303-5
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