Gut microbiome composition changes in obstructive sleep apnoea syndrome also in relation to excessive daytime sleepiness
Introduction: Obstructive sleep apnoea syndrome (OSAS) is considered a risk factor for several comorbidities. Alteration in gut microbiome was documented in OSAS animal models and in paediatric patients. This study analysed gut microbiome composition in adult patients with OSAS compared to healthy c...
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Elsevier
2025-03-01
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| Series: | Brain Research Bulletin |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0361923025000632 |
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| author | Mariana Fernandes Orazio Palmieri Stefano Castellana Matteo Spanetta Tiziana Latiano Clementina Lupo Claudia De Masi Christian Cardile Carmen Calvello Francesca Izzi Fabio Placidi Tommaso Mazza Nicola Biagio Mercuri Anna Latiano Claudio Liguori |
| author_facet | Mariana Fernandes Orazio Palmieri Stefano Castellana Matteo Spanetta Tiziana Latiano Clementina Lupo Claudia De Masi Christian Cardile Carmen Calvello Francesca Izzi Fabio Placidi Tommaso Mazza Nicola Biagio Mercuri Anna Latiano Claudio Liguori |
| author_sort | Mariana Fernandes |
| collection | DOAJ |
| description | Introduction: Obstructive sleep apnoea syndrome (OSAS) is considered a risk factor for several comorbidities. Alteration in gut microbiome was documented in OSAS animal models and in paediatric patients. This study analysed gut microbiome composition in adult patients with OSAS compared to healthy controls. Further, the effect of excessive daytime sleepiness (EDS) on gut microbiome was evaluated. Methods: Adult patients with OSAS underwent polysomnographic recording and completed the Epworth Sleepiness Scale (ESS) to assess EDS. Faecal samples were collected and compared between patients and healthy controls. Composition, community diversity, differences in taxa abundance profiles and sample dysbiosis were evaluated through 16S metagenomics and multiple bioinformatics algorithms. OSAS patients were distributed in two groups according to EDS (ESS score≥10) to assess differences in clinical, polysomnographic and faecal data. Results: Twenty-three OSAS patients were compared to 44 healthy controls. Patients presented significant differences of gut microbiome biodiversity, specifically in qualitative alpha diversity metrics (Faith’s PD Kruskal-Wallis test, p-value=0.003; Number_of_Observed_Features, p-value =0.001). OSAS patients tend to cluster together, at least for Jaccard and Unweighted UniFrac distance-based PERMANOVA tests (q-values=0.02 and =0.003, respectively). Several taxa were detected as different in abundance between OSAS patients and healthy controls, although, globally, OSAS patients cannot be considered as “dysbiotic”. Differences in bacteria composition were evident between OSAS patients with and those without EDS. Conclusions: OSAS is associated with gut microbiome alteration in adult patients. EDS in OSAS seems to characterize a different gut microbiome composition, although it can be only hypothesized a gut-mediated effect on EDS in OSAS. |
| format | Article |
| id | doaj-art-e2e67f487171416086e6a99dbd46fb5c |
| institution | DOAJ |
| issn | 1873-2747 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
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| spelling | doaj-art-e2e67f487171416086e6a99dbd46fb5c2025-08-20T02:47:21ZengElsevierBrain Research Bulletin1873-27472025-03-0122211125110.1016/j.brainresbull.2025.111251Gut microbiome composition changes in obstructive sleep apnoea syndrome also in relation to excessive daytime sleepinessMariana Fernandes0Orazio Palmieri1Stefano Castellana2Matteo Spanetta3Tiziana Latiano4Clementina Lupo5Claudia De Masi6Christian Cardile7Carmen Calvello8Francesca Izzi9Fabio Placidi10Tommaso Mazza11Nicola Biagio Mercuri12Anna Latiano13Claudio Liguori14Department of Systems Medicine, University of Rome Tor Vergata, Rome, ItalyDivision of Gastroenterology, Fondazione IRCCS “Casa Sollievo della Sofferenza”, San Giovanni Rotondo, ItalyBioinformatics Unit, Fondazione IRCCS “Casa Sollievo della Sofferenza”, San Giovanni Rotondo, ItalyDepartment of Systems Medicine, University of Rome Tor Vergata, Rome, ItalyDivision of Gastroenterology, Fondazione IRCCS “Casa Sollievo della Sofferenza”, San Giovanni Rotondo, ItalyDepartment of Systems Medicine, University of Rome Tor Vergata, Rome, ItalyNeurology Unit, University Hospital of Rome Tor Vergata, Rome, ItalyDepartment of Systems Medicine, University of Rome Tor Vergata, Rome, ItalyDepartment of Systems Medicine, University of Rome Tor Vergata, Rome, ItalyNeurology Unit, University Hospital of Rome Tor Vergata, Rome, ItalyDepartment of Systems Medicine, University of Rome Tor Vergata, Rome, Italy; Neurology Unit, University Hospital of Rome Tor Vergata, Rome, ItalyBioinformatics Unit, Fondazione IRCCS “Casa Sollievo della Sofferenza”, San Giovanni Rotondo, ItalyDepartment of Systems Medicine, University of Rome Tor Vergata, Rome, Italy; Neurology Unit, University Hospital of Rome Tor Vergata, Rome, ItalyDivision of Gastroenterology, Fondazione IRCCS “Casa Sollievo della Sofferenza”, San Giovanni Rotondo, ItalyDepartment of Systems Medicine, University of Rome Tor Vergata, Rome, Italy; Neurology Unit, University Hospital of Rome Tor Vergata, Rome, Italy; Correspondence to: Department of Systems Medicine, University of Rome “Tor Vergata”, Via Montpellier 1, Rome 00133, Italy.Introduction: Obstructive sleep apnoea syndrome (OSAS) is considered a risk factor for several comorbidities. Alteration in gut microbiome was documented in OSAS animal models and in paediatric patients. This study analysed gut microbiome composition in adult patients with OSAS compared to healthy controls. Further, the effect of excessive daytime sleepiness (EDS) on gut microbiome was evaluated. Methods: Adult patients with OSAS underwent polysomnographic recording and completed the Epworth Sleepiness Scale (ESS) to assess EDS. Faecal samples were collected and compared between patients and healthy controls. Composition, community diversity, differences in taxa abundance profiles and sample dysbiosis were evaluated through 16S metagenomics and multiple bioinformatics algorithms. OSAS patients were distributed in two groups according to EDS (ESS score≥10) to assess differences in clinical, polysomnographic and faecal data. Results: Twenty-three OSAS patients were compared to 44 healthy controls. Patients presented significant differences of gut microbiome biodiversity, specifically in qualitative alpha diversity metrics (Faith’s PD Kruskal-Wallis test, p-value=0.003; Number_of_Observed_Features, p-value =0.001). OSAS patients tend to cluster together, at least for Jaccard and Unweighted UniFrac distance-based PERMANOVA tests (q-values=0.02 and =0.003, respectively). Several taxa were detected as different in abundance between OSAS patients and healthy controls, although, globally, OSAS patients cannot be considered as “dysbiotic”. Differences in bacteria composition were evident between OSAS patients with and those without EDS. Conclusions: OSAS is associated with gut microbiome alteration in adult patients. EDS in OSAS seems to characterize a different gut microbiome composition, although it can be only hypothesized a gut-mediated effect on EDS in OSAS.http://www.sciencedirect.com/science/article/pii/S0361923025000632MicrobiotaSleep-disordered breathingIntermittent hypoxiaSleep fragmentationDaytime somnolence |
| spellingShingle | Mariana Fernandes Orazio Palmieri Stefano Castellana Matteo Spanetta Tiziana Latiano Clementina Lupo Claudia De Masi Christian Cardile Carmen Calvello Francesca Izzi Fabio Placidi Tommaso Mazza Nicola Biagio Mercuri Anna Latiano Claudio Liguori Gut microbiome composition changes in obstructive sleep apnoea syndrome also in relation to excessive daytime sleepiness Brain Research Bulletin Microbiota Sleep-disordered breathing Intermittent hypoxia Sleep fragmentation Daytime somnolence |
| title | Gut microbiome composition changes in obstructive sleep apnoea syndrome also in relation to excessive daytime sleepiness |
| title_full | Gut microbiome composition changes in obstructive sleep apnoea syndrome also in relation to excessive daytime sleepiness |
| title_fullStr | Gut microbiome composition changes in obstructive sleep apnoea syndrome also in relation to excessive daytime sleepiness |
| title_full_unstemmed | Gut microbiome composition changes in obstructive sleep apnoea syndrome also in relation to excessive daytime sleepiness |
| title_short | Gut microbiome composition changes in obstructive sleep apnoea syndrome also in relation to excessive daytime sleepiness |
| title_sort | gut microbiome composition changes in obstructive sleep apnoea syndrome also in relation to excessive daytime sleepiness |
| topic | Microbiota Sleep-disordered breathing Intermittent hypoxia Sleep fragmentation Daytime somnolence |
| url | http://www.sciencedirect.com/science/article/pii/S0361923025000632 |
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