Effect of Myoinositol and Antioxidants on Sperm Quality in Men with Metabolic Syndrome
This prospective longitudinal study investigated the effects of a dietary supplement in patients affected by reduced sperm motility (asthenospermic males) with metabolic syndrome. The product tested was Andrositol®, which contains myoinositol (MI) as principal compound, in association with other mol...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2016/1674950 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850167246513504256 |
|---|---|
| author | Mario Montanino Oliva Elisa Minutolo Assunta Lippa Paola Iaconianni Alberto Vaiarelli |
| author_facet | Mario Montanino Oliva Elisa Minutolo Assunta Lippa Paola Iaconianni Alberto Vaiarelli |
| author_sort | Mario Montanino Oliva |
| collection | DOAJ |
| description | This prospective longitudinal study investigated the effects of a dietary supplement in patients affected by reduced sperm motility (asthenospermic males) with metabolic syndrome. The product tested was Andrositol®, which contains myoinositol (MI) as principal compound, in association with other molecules, and the parameters evaluated were semen characteristics as well as hormone and metabolic profiles. The inclusion criteria were subjects aged over 18 years, with asthenospermia and metabolic syndrome. The exclusion criteria were presence of cryptorchidism, varicocele, and prostatitis. For this study, 45 males who had such features were enrolled. Their selection was made according to the 2010 World Health Organization (WHO) criteria (5th Edition) for the Evaluation of Human Semen. Hormone and metabolic profiles and semen parameters were assessed at the beginning of the study and after three months of treatment with Andrositol. The differences between the values before and after the supplementation were found statistically significant. Andrositol normalized the metabolic profile of these patients, improving their insulin sensitivity. Moreover, testosterone levels were increased and the semen characteristics, such as sperm concentration, motility, and morphology, highly improved. In conclusion, the association of MI with other molecules (micronutrients and vitamins) could be an effective therapy for metabolic disorders, as well as hormonal and spermatic changes responsible for male infertility. |
| format | Article |
| id | doaj-art-e2e5c535f05c4d08b9c1f2b392780a78 |
| institution | OA Journals |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-e2e5c535f05c4d08b9c1f2b392780a782025-08-20T02:21:14ZengWileyInternational Journal of Endocrinology1687-83371687-83452016-01-01201610.1155/2016/16749501674950Effect of Myoinositol and Antioxidants on Sperm Quality in Men with Metabolic SyndromeMario Montanino Oliva0Elisa Minutolo1Assunta Lippa2Paola Iaconianni3Alberto Vaiarelli4Department of Obstetrics & Gynecology, Santo Spirito Hospital, 00193 Rome, ItalyAltamedica IVF Unit, 00198 Rome, ItalyAltamedica IVF Unit, 00198 Rome, ItalyAltamedica IVF Unit, 00198 Rome, ItalyReproductive Medicine Unit, University Hospital, 98122 Messina, ItalyThis prospective longitudinal study investigated the effects of a dietary supplement in patients affected by reduced sperm motility (asthenospermic males) with metabolic syndrome. The product tested was Andrositol®, which contains myoinositol (MI) as principal compound, in association with other molecules, and the parameters evaluated were semen characteristics as well as hormone and metabolic profiles. The inclusion criteria were subjects aged over 18 years, with asthenospermia and metabolic syndrome. The exclusion criteria were presence of cryptorchidism, varicocele, and prostatitis. For this study, 45 males who had such features were enrolled. Their selection was made according to the 2010 World Health Organization (WHO) criteria (5th Edition) for the Evaluation of Human Semen. Hormone and metabolic profiles and semen parameters were assessed at the beginning of the study and after three months of treatment with Andrositol. The differences between the values before and after the supplementation were found statistically significant. Andrositol normalized the metabolic profile of these patients, improving their insulin sensitivity. Moreover, testosterone levels were increased and the semen characteristics, such as sperm concentration, motility, and morphology, highly improved. In conclusion, the association of MI with other molecules (micronutrients and vitamins) could be an effective therapy for metabolic disorders, as well as hormonal and spermatic changes responsible for male infertility.http://dx.doi.org/10.1155/2016/1674950 |
| spellingShingle | Mario Montanino Oliva Elisa Minutolo Assunta Lippa Paola Iaconianni Alberto Vaiarelli Effect of Myoinositol and Antioxidants on Sperm Quality in Men with Metabolic Syndrome International Journal of Endocrinology |
| title | Effect of Myoinositol and Antioxidants on Sperm Quality in Men with Metabolic Syndrome |
| title_full | Effect of Myoinositol and Antioxidants on Sperm Quality in Men with Metabolic Syndrome |
| title_fullStr | Effect of Myoinositol and Antioxidants on Sperm Quality in Men with Metabolic Syndrome |
| title_full_unstemmed | Effect of Myoinositol and Antioxidants on Sperm Quality in Men with Metabolic Syndrome |
| title_short | Effect of Myoinositol and Antioxidants on Sperm Quality in Men with Metabolic Syndrome |
| title_sort | effect of myoinositol and antioxidants on sperm quality in men with metabolic syndrome |
| url | http://dx.doi.org/10.1155/2016/1674950 |
| work_keys_str_mv | AT mariomontaninooliva effectofmyoinositolandantioxidantsonspermqualityinmenwithmetabolicsyndrome AT elisaminutolo effectofmyoinositolandantioxidantsonspermqualityinmenwithmetabolicsyndrome AT assuntalippa effectofmyoinositolandantioxidantsonspermqualityinmenwithmetabolicsyndrome AT paolaiaconianni effectofmyoinositolandantioxidantsonspermqualityinmenwithmetabolicsyndrome AT albertovaiarelli effectofmyoinositolandantioxidantsonspermqualityinmenwithmetabolicsyndrome |