The neurotoxicity of Paraquat and its degradation products on drosophila melanogaster
Abstract Photodegradation is a promising technique for remediating contaminated environmental matrices. It demonstrates significant potential in transforming organic contaminants into carbon dioxide, water, and inorganic anions through degradation reactions that involve transient oxidizing species,...
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Nature Portfolio
2025-05-01
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| Online Access: | https://doi.org/10.1038/s41598-025-86413-0 |
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| author | Douglas Lisboa Ramalho Jadyellen Rondon Silva Maria Eduarda Monteiro Martins dos Santos Maria Eduarda Silva Soares Andrielle Adelina Teodoro Jesus Thiago Henrique Oliveira Alves Michelle Fernanda Brugnera Sidnei Moura Anderson Oliveira Souza |
| author_facet | Douglas Lisboa Ramalho Jadyellen Rondon Silva Maria Eduarda Monteiro Martins dos Santos Maria Eduarda Silva Soares Andrielle Adelina Teodoro Jesus Thiago Henrique Oliveira Alves Michelle Fernanda Brugnera Sidnei Moura Anderson Oliveira Souza |
| author_sort | Douglas Lisboa Ramalho |
| collection | DOAJ |
| description | Abstract Photodegradation is a promising technique for remediating contaminated environmental matrices. It demonstrates significant potential in transforming organic contaminants into carbon dioxide, water, and inorganic anions through degradation reactions that involve transient oxidizing species, mainly hydroxyl radicals generated by ultraviolet (UV) irradiation. In this study, we investigated whether the photodegradation of Paraquat (PQ) with UV irradiation reduced its toxicity in Drosophila melanogaster. Our results indicate that ingesting PQ degradation products by larvae resulted in a low axial ratio (pupal volume). In the adults, it resulted in markedly diminished climbing ability in a time-dependent manner after 10 days of feeding. In addition, exposure of D. melanogaster to photodegradation of PQ reduced acetylcholinesterase and citrate synthase activities but improved oxidative stress, as evidenced by protein carbonyl, and lactate production. These results suggest that the photodegradation of PQ with UV irradiation produced PQ fragments with higher toxicity than PQ, while the precise mechanism of its action requires further investigation. |
| format | Article |
| id | doaj-art-e2e542288e2e4a10820a40dae681cbc2 |
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| issn | 2045-2322 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-e2e542288e2e4a10820a40dae681cbc22025-08-20T01:51:27ZengNature PortfolioScientific Reports2045-23222025-05-0115111110.1038/s41598-025-86413-0The neurotoxicity of Paraquat and its degradation products on drosophila melanogasterDouglas Lisboa Ramalho0Jadyellen Rondon Silva1Maria Eduarda Monteiro Martins dos Santos2Maria Eduarda Silva Soares3Andrielle Adelina Teodoro Jesus4Thiago Henrique Oliveira Alves5Michelle Fernanda Brugnera6Sidnei Moura7Anderson Oliveira Souza8Mitochondrial Metabolism and Neurotoxicology Laboratory, Department of Chemistry, Institute of Chemistry, Federal University of Mato GrossoMitochondrial Metabolism and Neurotoxicology Laboratory, Department of Chemistry, Institute of Chemistry, Federal University of Mato GrossoMitochondrial Metabolism and Neurotoxicology Laboratory, Department of Chemistry, Institute of Chemistry, Federal University of Mato GrossoMitochondrial Metabolism and Neurotoxicology Laboratory, Department of Chemistry, Institute of Chemistry, Federal University of Mato GrossoMitochondrial Metabolism and Neurotoxicology Laboratory, Department of Chemistry, Institute of Chemistry, Federal University of Mato GrossoMitochondrial Metabolism and Neurotoxicology Laboratory, Department of Chemistry, Institute of Chemistry, Federal University of Mato GrossoBiocide Residue Analysis Laboratory, Department of Chemistry, Institute of Chemistry, Federal University of Mato GrossoBiotechnology of Natural and Synthetic Products Laboratory, Institute of Biotechnology, University of Caxias do SulMitochondrial Metabolism and Neurotoxicology Laboratory, Department of Chemistry, Institute of Chemistry, Federal University of Mato GrossoAbstract Photodegradation is a promising technique for remediating contaminated environmental matrices. It demonstrates significant potential in transforming organic contaminants into carbon dioxide, water, and inorganic anions through degradation reactions that involve transient oxidizing species, mainly hydroxyl radicals generated by ultraviolet (UV) irradiation. In this study, we investigated whether the photodegradation of Paraquat (PQ) with UV irradiation reduced its toxicity in Drosophila melanogaster. Our results indicate that ingesting PQ degradation products by larvae resulted in a low axial ratio (pupal volume). In the adults, it resulted in markedly diminished climbing ability in a time-dependent manner after 10 days of feeding. In addition, exposure of D. melanogaster to photodegradation of PQ reduced acetylcholinesterase and citrate synthase activities but improved oxidative stress, as evidenced by protein carbonyl, and lactate production. These results suggest that the photodegradation of PQ with UV irradiation produced PQ fragments with higher toxicity than PQ, while the precise mechanism of its action requires further investigation.https://doi.org/10.1038/s41598-025-86413-0PhotodegradationDegradation productsDrosophila melanogasterUV irradiationNeurotoxicity |
| spellingShingle | Douglas Lisboa Ramalho Jadyellen Rondon Silva Maria Eduarda Monteiro Martins dos Santos Maria Eduarda Silva Soares Andrielle Adelina Teodoro Jesus Thiago Henrique Oliveira Alves Michelle Fernanda Brugnera Sidnei Moura Anderson Oliveira Souza The neurotoxicity of Paraquat and its degradation products on drosophila melanogaster Scientific Reports Photodegradation Degradation products Drosophila melanogaster UV irradiation Neurotoxicity |
| title | The neurotoxicity of Paraquat and its degradation products on drosophila melanogaster |
| title_full | The neurotoxicity of Paraquat and its degradation products on drosophila melanogaster |
| title_fullStr | The neurotoxicity of Paraquat and its degradation products on drosophila melanogaster |
| title_full_unstemmed | The neurotoxicity of Paraquat and its degradation products on drosophila melanogaster |
| title_short | The neurotoxicity of Paraquat and its degradation products on drosophila melanogaster |
| title_sort | neurotoxicity of paraquat and its degradation products on drosophila melanogaster |
| topic | Photodegradation Degradation products Drosophila melanogaster UV irradiation Neurotoxicity |
| url | https://doi.org/10.1038/s41598-025-86413-0 |
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