Redox-switchable multicolor luminescent polymers for theragnosis of osteoarthritis
Abstract Nonaromatic and nonconjugated fluorescent materials have garnered increasing attention in recent years. However, most non-classical chromophores are derived from electro-rich nitrogen and oxygen atoms, which suffer from short emission wavelengths, low efficiency, limited responsiveness, and...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-54473-x |
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| _version_ | 1849221118174429184 |
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| author | Chuan Peng Yuling Zhu Kaibo Zhang Yiwei Wang Yi Zheng Yang Liu Weili Fu Hong Tan Qiang Fu Mingming Ding |
| author_facet | Chuan Peng Yuling Zhu Kaibo Zhang Yiwei Wang Yi Zheng Yang Liu Weili Fu Hong Tan Qiang Fu Mingming Ding |
| author_sort | Chuan Peng |
| collection | DOAJ |
| description | Abstract Nonaromatic and nonconjugated fluorescent materials have garnered increasing attention in recent years. However, most non-classical chromophores are derived from electro-rich nitrogen and oxygen atoms, which suffer from short emission wavelengths, low efficiency, limited responsiveness, and obscure luminescence mechanisms. Here we present an emission mechanism in bioactive polycysteine, an aliphatic polymer that displays polymerization- and aggregation-induced emission, high quantum yield, and multicolor emission properties. We show that the hydrogen atoms bonded to the sulfur atoms play a crucial role in luminescence. This enables reversible modulation of polymer fluorescence under reducing and oxidizing conditions, facilitating specific imaging and quantitative detection of redox species in cells and in vivo. Furthermore, the polymer exhibits better anti-inflammatory and antioxidative activities compared to first-line clinical antioxidants, offering a promising platform for in vivo theragnosis of diseases such as osteoarthritis. |
| format | Article |
| id | doaj-art-e2dea27dea414bbea824117a6b385401 |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-e2dea27dea414bbea824117a6b3854012024-11-24T12:34:00ZengNature PortfolioNature Communications2041-17232024-11-0115111410.1038/s41467-024-54473-xRedox-switchable multicolor luminescent polymers for theragnosis of osteoarthritisChuan Peng0Yuling Zhu1Kaibo Zhang2Yiwei Wang3Yi Zheng4Yang Liu5Weili Fu6Hong Tan7Qiang Fu8Mingming Ding9College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan UniversityCollege of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan UniversitySports Medicine Center, Department of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan UniversityCollege of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan UniversityCollege of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan UniversityCollege of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan UniversitySports Medicine Center, Department of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan UniversityCollege of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan UniversityCollege of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan UniversityCollege of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan UniversityAbstract Nonaromatic and nonconjugated fluorescent materials have garnered increasing attention in recent years. However, most non-classical chromophores are derived from electro-rich nitrogen and oxygen atoms, which suffer from short emission wavelengths, low efficiency, limited responsiveness, and obscure luminescence mechanisms. Here we present an emission mechanism in bioactive polycysteine, an aliphatic polymer that displays polymerization- and aggregation-induced emission, high quantum yield, and multicolor emission properties. We show that the hydrogen atoms bonded to the sulfur atoms play a crucial role in luminescence. This enables reversible modulation of polymer fluorescence under reducing and oxidizing conditions, facilitating specific imaging and quantitative detection of redox species in cells and in vivo. Furthermore, the polymer exhibits better anti-inflammatory and antioxidative activities compared to first-line clinical antioxidants, offering a promising platform for in vivo theragnosis of diseases such as osteoarthritis.https://doi.org/10.1038/s41467-024-54473-x |
| spellingShingle | Chuan Peng Yuling Zhu Kaibo Zhang Yiwei Wang Yi Zheng Yang Liu Weili Fu Hong Tan Qiang Fu Mingming Ding Redox-switchable multicolor luminescent polymers for theragnosis of osteoarthritis Nature Communications |
| title | Redox-switchable multicolor luminescent polymers for theragnosis of osteoarthritis |
| title_full | Redox-switchable multicolor luminescent polymers for theragnosis of osteoarthritis |
| title_fullStr | Redox-switchable multicolor luminescent polymers for theragnosis of osteoarthritis |
| title_full_unstemmed | Redox-switchable multicolor luminescent polymers for theragnosis of osteoarthritis |
| title_short | Redox-switchable multicolor luminescent polymers for theragnosis of osteoarthritis |
| title_sort | redox switchable multicolor luminescent polymers for theragnosis of osteoarthritis |
| url | https://doi.org/10.1038/s41467-024-54473-x |
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