Association between aortic and intracranial aneurysms (ATAAC Study)
Objective: Aortic aneurysms (AAs) and intracranial aneurysms (IAs) are two serious conditions that occur together in 7.2% and 11.8% of cases, respectively. The aim of this study was to find common risk factors between AAs and IAs that could be used for targeted screening of combined disease. Methods...
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Elsevier
2025-01-01
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| Series: | JVS-Vascular Insights |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2949912725000509 |
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| author | Tom Le Corvec, MD, PhD Romain Bourcier, MD, PhD Matilde Karakachoff, MSc Pacôme Constant dit Beaufils, MD, MSc Hubert Desal, MD, PhD Jean-Michel Serfaty, MD, PhD Guillaume Guimbretière, MD, MSc Blandine Maurel, MD, PhD |
| author_facet | Tom Le Corvec, MD, PhD Romain Bourcier, MD, PhD Matilde Karakachoff, MSc Pacôme Constant dit Beaufils, MD, MSc Hubert Desal, MD, PhD Jean-Michel Serfaty, MD, PhD Guillaume Guimbretière, MD, MSc Blandine Maurel, MD, PhD |
| author_sort | Tom Le Corvec, MD, PhD |
| collection | DOAJ |
| description | Objective: Aortic aneurysms (AAs) and intracranial aneurysms (IAs) are two serious conditions that occur together in 7.2% and 11.8% of cases, respectively. The aim of this study was to find common risk factors between AAs and IAs that could be used for targeted screening of combined disease. Methods: Retrospective data were collected from consecutive patients with a combined condition (AA + IA, target group, taken from our Biomedical Data Warehouse from 2012 to 2020) and compared with two control groups: a first control group of patients operated on for an AA without IA (taken from a prospectively maintained database) and a second control group of patients with IA only (taken from the national ICAN database). Univariate and multivariate analyses were performed to compare the target group with each control group. Results: We included 67 patients with combined disease, 153 with isolated AA and 128 with isolated IA. In patients with AA, the patient characteristics associated with an increased risk of also having IA were peripheral arterial occlusive disease (odds ratio [OR], 3.02; P = .007) and multiple sites of AA (OR, 2.97; P = .002). Among patients with an IA, the following characteristics were associated with an increased risk of also having an AA: hypertension (OR, 3.28; P = .0005), coronary artery disease (OR, 12.07; P < .0001), and peripheral artery disease (OR, 4.14; P = .0001). The location of IA in the anterior communicating artery tended to lead to an increased risk of having AA (OR, 1.92; P = .09). Conclusions: This pilot study identifies several characteristics that could be used to select patients at risk for a combined aneurysmal disease (AAs and IAs) for screening. A prospective study is required to confirm these data. |
| format | Article |
| id | doaj-art-e2d8deef2a8b4528b350973f49d6e227 |
| institution | OA Journals |
| issn | 2949-9127 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
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| series | JVS-Vascular Insights |
| spelling | doaj-art-e2d8deef2a8b4528b350973f49d6e2272025-08-20T02:25:11ZengElsevierJVS-Vascular Insights2949-91272025-01-01310023310.1016/j.jvsvi.2025.100233Association between aortic and intracranial aneurysms (ATAAC Study)Tom Le Corvec, MD, PhD0Romain Bourcier, MD, PhD1Matilde Karakachoff, MSc2Pacôme Constant dit Beaufils, MD, MSc3Hubert Desal, MD, PhD4Jean-Michel Serfaty, MD, PhD5Guillaume Guimbretière, MD, MSc6Blandine Maurel, MD, PhD7Department of Cardiac and Vascular Surgery, L'institut du thorax, CHU Nantes, Université de Nantes, Nantes, FranceDepartment of Diagnostic and Interventional Neuroradiology, CNRS, INSERM, L'institut du thorax, CHU Nantes, Nantes, FranceCentre d'Investigation Clinique 1413, INSERM, Clinique des Données, CHU Nantes, Santé Publique, Pôle Hospitalo-Universitaire 11, Université de Nantes, Nantes, FranceDepartment of Diagnostic and Interventional Neuroradiology, CNRS, INSERM, L'institut du thorax, CHU Nantes, Nantes, France; Centre d'Investigation Clinique 1413, INSERM, Clinique des Données, CHU Nantes, Santé Publique, Pôle Hospitalo-Universitaire 11, Université de Nantes, Nantes, FranceDepartment of Diagnostic and Interventional Neuroradiology, CNRS, INSERM, L'institut du thorax, CHU Nantes, Nantes, FranceDepartment of Vascular Radiology, L'institut du thorax, CHU Nantes, Université de Nantes, Nantes, FranceDepartment of Cardiac and Vascular Surgery, L'institut du thorax, CHU Nantes, Université de Nantes, Nantes, FranceDepartment of Cardiac and Vascular Surgery, L'institut du thorax, CHU Nantes, Université de Nantes, Nantes, France; Correspondence: Blandine Maurel, MD, PhD, CHU Nantes, l’Institut du thorax, service de chirurgie vasculaire, Boulevard Professeur Jacques Monod, Nantes Cedex 1 44093, FranceObjective: Aortic aneurysms (AAs) and intracranial aneurysms (IAs) are two serious conditions that occur together in 7.2% and 11.8% of cases, respectively. The aim of this study was to find common risk factors between AAs and IAs that could be used for targeted screening of combined disease. Methods: Retrospective data were collected from consecutive patients with a combined condition (AA + IA, target group, taken from our Biomedical Data Warehouse from 2012 to 2020) and compared with two control groups: a first control group of patients operated on for an AA without IA (taken from a prospectively maintained database) and a second control group of patients with IA only (taken from the national ICAN database). Univariate and multivariate analyses were performed to compare the target group with each control group. Results: We included 67 patients with combined disease, 153 with isolated AA and 128 with isolated IA. In patients with AA, the patient characteristics associated with an increased risk of also having IA were peripheral arterial occlusive disease (odds ratio [OR], 3.02; P = .007) and multiple sites of AA (OR, 2.97; P = .002). Among patients with an IA, the following characteristics were associated with an increased risk of also having an AA: hypertension (OR, 3.28; P = .0005), coronary artery disease (OR, 12.07; P < .0001), and peripheral artery disease (OR, 4.14; P = .0001). The location of IA in the anterior communicating artery tended to lead to an increased risk of having AA (OR, 1.92; P = .09). Conclusions: This pilot study identifies several characteristics that could be used to select patients at risk for a combined aneurysmal disease (AAs and IAs) for screening. A prospective study is required to confirm these data.http://www.sciencedirect.com/science/article/pii/S2949912725000509Intracranial aneurysmAortic aneurysmCardiovascular surgeryVascular radiologyInterventional neuroradiology |
| spellingShingle | Tom Le Corvec, MD, PhD Romain Bourcier, MD, PhD Matilde Karakachoff, MSc Pacôme Constant dit Beaufils, MD, MSc Hubert Desal, MD, PhD Jean-Michel Serfaty, MD, PhD Guillaume Guimbretière, MD, MSc Blandine Maurel, MD, PhD Association between aortic and intracranial aneurysms (ATAAC Study) JVS-Vascular Insights Intracranial aneurysm Aortic aneurysm Cardiovascular surgery Vascular radiology Interventional neuroradiology |
| title | Association between aortic and intracranial aneurysms (ATAAC Study) |
| title_full | Association between aortic and intracranial aneurysms (ATAAC Study) |
| title_fullStr | Association between aortic and intracranial aneurysms (ATAAC Study) |
| title_full_unstemmed | Association between aortic and intracranial aneurysms (ATAAC Study) |
| title_short | Association between aortic and intracranial aneurysms (ATAAC Study) |
| title_sort | association between aortic and intracranial aneurysms ataac study |
| topic | Intracranial aneurysm Aortic aneurysm Cardiovascular surgery Vascular radiology Interventional neuroradiology |
| url | http://www.sciencedirect.com/science/article/pii/S2949912725000509 |
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