Liposomal Formulations: A Recent Update
Liposome-based drug delivery technologies have showed potential in enhancing medication safety and efficacy. Innovative drug loading and release mechanisms highlighted in this review of next-generation liposomal formulations. Due to poor drug release kinetics and loading capacity, conventional lipos...
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2024-12-01
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| Series: | Pharmaceutics |
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| author | Surendra S. Agrawal Vrinda Baliga Vaishali Y. Londhe |
| author_facet | Surendra S. Agrawal Vrinda Baliga Vaishali Y. Londhe |
| author_sort | Surendra S. Agrawal |
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| description | Liposome-based drug delivery technologies have showed potential in enhancing medication safety and efficacy. Innovative drug loading and release mechanisms highlighted in this review of next-generation liposomal formulations. Due to poor drug release kinetics and loading capacity, conventional liposomes have limited clinical use. Scientists have developed new liposomal carrier medication release control and encapsulation methods to address these limits. Drug encapsulation can be optimized by creating lipid compositions that match a drug’s charge and hydrophobicity. By selecting lipids and adding co-solvents or surfactants, scientists have increased drug loading in liposomal formulations while maintaining stability. Nanotechnology has also created multifunctional liposomes with triggered release and personalized drug delivery. Surface modification methods like PEGylation and ligand conjugation can direct liposomes to disease regions, improving therapeutic efficacy and reducing off-target effects. In addition to drug loading, researchers have focused on spatiotemporal modulation of liposomal carrier medication release. Stimuli-responsive liposomes release drugs in response to bodily signals. Liposomes can be pH- or temperature-sensitive. To improve therapeutic efficacy and reduce systemic toxicity, researchers added stimuli-responsive components to liposomal membranes to precisely control drug release kinetics. Advanced drug delivery technologies like magnetic targeting and ultrasound. Pro Drug, RNA Liposomes approach may improve liposomal medication administration. Magnetic targeting helps liposomes aggregate at illness sites and improves drug delivery, whereas ultrasound-mediated drug release facilitates on-demand release of encapsulated medicines. This review also covers recent preclinical and clinical research showing the therapeutic promise of next-generation liposomal formulations for cancer, infectious diseases, neurological disorders and inflammatory disorders. The transfer of these innovative liposomal formulations from lab to clinical practice involves key difficulties such scalability, manufacturing difficulty, and regulatory limits. |
| format | Article |
| id | doaj-art-e2d8cc492abf419b853873a886359cd1 |
| institution | Kabale University |
| issn | 1999-4923 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
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| series | Pharmaceutics |
| spelling | doaj-art-e2d8cc492abf419b853873a886359cd12025-01-24T13:45:39ZengMDPI AGPharmaceutics1999-49232024-12-011713610.3390/pharmaceutics17010036Liposomal Formulations: A Recent UpdateSurendra S. Agrawal0Vrinda Baliga1Vaishali Y. Londhe2Datta Meghe College of Pharmacy, Datta Meghe Institute of Higher Education and Research (DU), Sawangi (M), Wardha 442001, Maharashtra, IndiaShobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKM’s NMIMS, V.L. Mehta Road, Vile Parle (W), Mumbai 400056, Maharashtra, IndiaShobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKM’s NMIMS, V.L. Mehta Road, Vile Parle (W), Mumbai 400056, Maharashtra, IndiaLiposome-based drug delivery technologies have showed potential in enhancing medication safety and efficacy. Innovative drug loading and release mechanisms highlighted in this review of next-generation liposomal formulations. Due to poor drug release kinetics and loading capacity, conventional liposomes have limited clinical use. Scientists have developed new liposomal carrier medication release control and encapsulation methods to address these limits. Drug encapsulation can be optimized by creating lipid compositions that match a drug’s charge and hydrophobicity. By selecting lipids and adding co-solvents or surfactants, scientists have increased drug loading in liposomal formulations while maintaining stability. Nanotechnology has also created multifunctional liposomes with triggered release and personalized drug delivery. Surface modification methods like PEGylation and ligand conjugation can direct liposomes to disease regions, improving therapeutic efficacy and reducing off-target effects. In addition to drug loading, researchers have focused on spatiotemporal modulation of liposomal carrier medication release. Stimuli-responsive liposomes release drugs in response to bodily signals. Liposomes can be pH- or temperature-sensitive. To improve therapeutic efficacy and reduce systemic toxicity, researchers added stimuli-responsive components to liposomal membranes to precisely control drug release kinetics. Advanced drug delivery technologies like magnetic targeting and ultrasound. Pro Drug, RNA Liposomes approach may improve liposomal medication administration. Magnetic targeting helps liposomes aggregate at illness sites and improves drug delivery, whereas ultrasound-mediated drug release facilitates on-demand release of encapsulated medicines. This review also covers recent preclinical and clinical research showing the therapeutic promise of next-generation liposomal formulations for cancer, infectious diseases, neurological disorders and inflammatory disorders. The transfer of these innovative liposomal formulations from lab to clinical practice involves key difficulties such scalability, manufacturing difficulty, and regulatory limits.https://www.mdpi.com/1999-4923/17/1/36liposomesadvanced technologiesenhancing drug loading capacitysurface modificationpreclinical and clinical studies |
| spellingShingle | Surendra S. Agrawal Vrinda Baliga Vaishali Y. Londhe Liposomal Formulations: A Recent Update Pharmaceutics liposomes advanced technologies enhancing drug loading capacity surface modification preclinical and clinical studies |
| title | Liposomal Formulations: A Recent Update |
| title_full | Liposomal Formulations: A Recent Update |
| title_fullStr | Liposomal Formulations: A Recent Update |
| title_full_unstemmed | Liposomal Formulations: A Recent Update |
| title_short | Liposomal Formulations: A Recent Update |
| title_sort | liposomal formulations a recent update |
| topic | liposomes advanced technologies enhancing drug loading capacity surface modification preclinical and clinical studies |
| url | https://www.mdpi.com/1999-4923/17/1/36 |
| work_keys_str_mv | AT surendrasagrawal liposomalformulationsarecentupdate AT vrindabaliga liposomalformulationsarecentupdate AT vaishaliylondhe liposomalformulationsarecentupdate |