Simultaneous cyclin D1 overexpression and p27kip1 knockdown enable robust Müller glia cell cycle reactivation in uninjured mouse retina

Simultaneous cyclin D1 overexpression and p27kip1 knockdown enable robust Müller glia cell cycle reactivation in uninjured mouse retina

Harnessing the regenerative potential of endogenous stem cells to restore lost neurons is a promising strategy for treating neurodegenerative disorders. Müller glia (MG), the primary glial cell type in the retina, exhibit extraordinary regenerative abilities in zebrafish, proliferating and different...

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Bibliographic Details
Main Authors: Zhifei Wu, Baoshan Liao, Julia Ying, Jan Keung, Zongli Zheng, Virpi Ahola, Wenjun Xiong
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-04-01
Series:eLife
Subjects:
retina
regeneration
Müller glia
cell cycle regulator
cyclin D1
p27kip1
Online Access:https://elifesciences.org/articles/100904
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