Characterization of In Vivo Retinal Lesions of Diabetic Retinopathy Using Adaptive Optics Scanning Laser Ophthalmoscopy
Purpose. To characterize hallmark diabetic retinopathy (DR) lesions utilizing adaptive optics scanning laser ophthalmoscopy (AOSLO) and to compare AOSLO findings with those on standard imaging techniques. Methods. Cross-sectional study including 35 eyes of 34 study participants. AOSLO confocal and m...
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Wiley
2018-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2018/7492946 |
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| author | Sonja G. Karst Jan Lammer Salma H. Radwan Hanna Kwak Paolo S. Silva Stephen A. Burns Lloyd Paul Aiello Jennifer K. Sun |
| author_facet | Sonja G. Karst Jan Lammer Salma H. Radwan Hanna Kwak Paolo S. Silva Stephen A. Burns Lloyd Paul Aiello Jennifer K. Sun |
| author_sort | Sonja G. Karst |
| collection | DOAJ |
| description | Purpose. To characterize hallmark diabetic retinopathy (DR) lesions utilizing adaptive optics scanning laser ophthalmoscopy (AOSLO) and to compare AOSLO findings with those on standard imaging techniques. Methods. Cross-sectional study including 35 eyes of 34 study participants. AOSLO confocal and multiply scattered light (MSL) imaging were performed in eyes with DR. Color fundus photographs (CF), infrared images of the macula (Spectralis, Heidelberg), and Spectralis spectral domain optical coherence tomography SDOCT B-scans of each lesion were obtained and registered to corresponding AOSLO images. Main Outcome Measures. Individual lesion characterization by AOSLO imaging. AOSLO appearance was compared with CF and SDOCT imaging. Results. Characterized lesions encompassed 52 microaneurysms (MA), 20 intraretinal microvascular abnormalities (IRMA), 7 neovascularization (NV), 11 hard exudates (HE), 5 dot/blot hemorrhages (HEM), 4 cotton wool spots (CWS), and 14 intraretinal cysts. AOSLO allowed assessment of perfusion in vascular lesions and enabled the identification of vascular lesions that could not be visualized on CF or SDOCT. Conclusions. AOSLO imaging provides detailed, noninvasive in vivo visualization of DR lesions enhancing the assessment of morphological characteristics. These unique AOSLO attributes may enable new insights into the pathological changes of DR in response to disease onset, development, regression, and response to therapy. |
| format | Article |
| id | doaj-art-e2cc62844fcd4339b7f1c951f7a36668 |
| institution | DOAJ |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
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| series | International Journal of Endocrinology |
| spelling | doaj-art-e2cc62844fcd4339b7f1c951f7a366682025-08-20T03:21:06ZengWileyInternational Journal of Endocrinology1687-83371687-83452018-01-01201810.1155/2018/74929467492946Characterization of In Vivo Retinal Lesions of Diabetic Retinopathy Using Adaptive Optics Scanning Laser OphthalmoscopySonja G. Karst0Jan Lammer1Salma H. Radwan2Hanna Kwak3Paolo S. Silva4Stephen A. Burns5Lloyd Paul Aiello6Jennifer K. Sun7Beetham Eye Institute, Joslin Diabetes Center, Boston, MA, USABeetham Eye Institute, Joslin Diabetes Center, Boston, MA, USABeetham Eye Institute, Joslin Diabetes Center, Boston, MA, USABeetham Eye Institute, Joslin Diabetes Center, Boston, MA, USABeetham Eye Institute, Joslin Diabetes Center, Boston, MA, USASchool of Optometry, Indiana University, Bloomington, IN, USABeetham Eye Institute, Joslin Diabetes Center, Boston, MA, USABeetham Eye Institute, Joslin Diabetes Center, Boston, MA, USAPurpose. To characterize hallmark diabetic retinopathy (DR) lesions utilizing adaptive optics scanning laser ophthalmoscopy (AOSLO) and to compare AOSLO findings with those on standard imaging techniques. Methods. Cross-sectional study including 35 eyes of 34 study participants. AOSLO confocal and multiply scattered light (MSL) imaging were performed in eyes with DR. Color fundus photographs (CF), infrared images of the macula (Spectralis, Heidelberg), and Spectralis spectral domain optical coherence tomography SDOCT B-scans of each lesion were obtained and registered to corresponding AOSLO images. Main Outcome Measures. Individual lesion characterization by AOSLO imaging. AOSLO appearance was compared with CF and SDOCT imaging. Results. Characterized lesions encompassed 52 microaneurysms (MA), 20 intraretinal microvascular abnormalities (IRMA), 7 neovascularization (NV), 11 hard exudates (HE), 5 dot/blot hemorrhages (HEM), 4 cotton wool spots (CWS), and 14 intraretinal cysts. AOSLO allowed assessment of perfusion in vascular lesions and enabled the identification of vascular lesions that could not be visualized on CF or SDOCT. Conclusions. AOSLO imaging provides detailed, noninvasive in vivo visualization of DR lesions enhancing the assessment of morphological characteristics. These unique AOSLO attributes may enable new insights into the pathological changes of DR in response to disease onset, development, regression, and response to therapy.http://dx.doi.org/10.1155/2018/7492946 |
| spellingShingle | Sonja G. Karst Jan Lammer Salma H. Radwan Hanna Kwak Paolo S. Silva Stephen A. Burns Lloyd Paul Aiello Jennifer K. Sun Characterization of In Vivo Retinal Lesions of Diabetic Retinopathy Using Adaptive Optics Scanning Laser Ophthalmoscopy International Journal of Endocrinology |
| title | Characterization of In Vivo Retinal Lesions of Diabetic Retinopathy Using Adaptive Optics Scanning Laser Ophthalmoscopy |
| title_full | Characterization of In Vivo Retinal Lesions of Diabetic Retinopathy Using Adaptive Optics Scanning Laser Ophthalmoscopy |
| title_fullStr | Characterization of In Vivo Retinal Lesions of Diabetic Retinopathy Using Adaptive Optics Scanning Laser Ophthalmoscopy |
| title_full_unstemmed | Characterization of In Vivo Retinal Lesions of Diabetic Retinopathy Using Adaptive Optics Scanning Laser Ophthalmoscopy |
| title_short | Characterization of In Vivo Retinal Lesions of Diabetic Retinopathy Using Adaptive Optics Scanning Laser Ophthalmoscopy |
| title_sort | characterization of in vivo retinal lesions of diabetic retinopathy using adaptive optics scanning laser ophthalmoscopy |
| url | http://dx.doi.org/10.1155/2018/7492946 |
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