Melanosis of the Bladder: Possible Pathogenetic Mechanisms
Melanin accumulation within the bladder urothelium and/or macrophages in the lamina propria (melanosis of the bladder) is a very rare phenomenon of unknown pathogenesis. Its rarity argues for a complex, likely multifactorial, causation. We describe bladder melanosis developing after Botox therapy in...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Case Reports in Urology |
| Online Access: | http://dx.doi.org/10.1155/2022/6221499 |
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| author | Justin E. Dupey Sarah J. Wood Richard Y. Ball |
| author_facet | Justin E. Dupey Sarah J. Wood Richard Y. Ball |
| author_sort | Justin E. Dupey |
| collection | DOAJ |
| description | Melanin accumulation within the bladder urothelium and/or macrophages in the lamina propria (melanosis of the bladder) is a very rare phenomenon of unknown pathogenesis. Its rarity argues for a complex, likely multifactorial, causation. We describe bladder melanosis developing after Botox therapy in an elderly woman with a history of overactive bladder, treated grade 2 uterovaginal prolapse, and episodes of urinary tract infection and speculate that one factor (probably of many) in its pathogenesis may be a derangement of local neurourothelial interactions. |
| format | Article |
| id | doaj-art-e2c68a94446e4e8cba99c70999a3592d |
| institution | OA Journals |
| issn | 2090-6978 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Urology |
| spelling | doaj-art-e2c68a94446e4e8cba99c70999a3592d2025-08-20T02:21:14ZengWileyCase Reports in Urology2090-69782022-01-01202210.1155/2022/6221499Melanosis of the Bladder: Possible Pathogenetic MechanismsJustin E. Dupey0Sarah J. Wood1Richard Y. Ball2Norfolk and Waveney Cellular Pathology ServiceDepartment of UrologyNorfolk and Waveney Cellular Pathology ServiceMelanin accumulation within the bladder urothelium and/or macrophages in the lamina propria (melanosis of the bladder) is a very rare phenomenon of unknown pathogenesis. Its rarity argues for a complex, likely multifactorial, causation. We describe bladder melanosis developing after Botox therapy in an elderly woman with a history of overactive bladder, treated grade 2 uterovaginal prolapse, and episodes of urinary tract infection and speculate that one factor (probably of many) in its pathogenesis may be a derangement of local neurourothelial interactions.http://dx.doi.org/10.1155/2022/6221499 |
| spellingShingle | Justin E. Dupey Sarah J. Wood Richard Y. Ball Melanosis of the Bladder: Possible Pathogenetic Mechanisms Case Reports in Urology |
| title | Melanosis of the Bladder: Possible Pathogenetic Mechanisms |
| title_full | Melanosis of the Bladder: Possible Pathogenetic Mechanisms |
| title_fullStr | Melanosis of the Bladder: Possible Pathogenetic Mechanisms |
| title_full_unstemmed | Melanosis of the Bladder: Possible Pathogenetic Mechanisms |
| title_short | Melanosis of the Bladder: Possible Pathogenetic Mechanisms |
| title_sort | melanosis of the bladder possible pathogenetic mechanisms |
| url | http://dx.doi.org/10.1155/2022/6221499 |
| work_keys_str_mv | AT justinedupey melanosisofthebladderpossiblepathogeneticmechanisms AT sarahjwood melanosisofthebladderpossiblepathogeneticmechanisms AT richardyball melanosisofthebladderpossiblepathogeneticmechanisms |