New Insights into the Association between Fibrinogen and Coronary Atherosclerotic Plaque Vulnerability: An Intravascular Optical Coherence Tomography Study
Background. Fibrinogen levels have been associated with coronary plaque vulnerability in experimental studies. However, it has yet to be determined if serum fibrinogen levels are independently associated with coronary plaque vulnerability as detected by optical coherence tomography (OCT) in patients...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Cardiovascular Therapeutics |
| Online Access: | http://dx.doi.org/10.1155/2019/8563717 |
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| _version_ | 1850167236830953472 |
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| author | Jun Wang Lu Jia Xing Li Siyu Jin Xiaomei Li Fen Liu Chunfang Shan Yu Zhang Yining Yang |
| author_facet | Jun Wang Lu Jia Xing Li Siyu Jin Xiaomei Li Fen Liu Chunfang Shan Yu Zhang Yining Yang |
| author_sort | Jun Wang |
| collection | DOAJ |
| description | Background. Fibrinogen levels have been associated with coronary plaque vulnerability in experimental studies. However, it has yet to be determined if serum fibrinogen levels are independently associated with coronary plaque vulnerability as detected by optical coherence tomography (OCT) in patients with coronary heart disease. Methods. Patients with coronary heart disease (CHD) who underwent coronary angiography and OCT in our department from January 2015 to August 2018 were included in this study. Coronary lesions were categorized as ruptured plaque, nonruptured with thin-cap fibroatheroma (TCFA), and nonruptured and non-TCFA. Presence of ruptured plaque and nonruptured with TCFA was considered to be vulnerable lesions. Determinants of coronary vulnerability were evaluated by multivariable logistic regression analyses. Results. A total of 154 patients were included in this study; 17 patients had ruptured plaques, 15 had nonruptured plaques with TCFA, and 122 had nonruptured plaques with non-TCFA. Results of univariate analyses showed that being male, diabetes, current smoking, high body mass index (BMI), and clinical diagnosis of acute coronary syndrome (ACS) were associated with coronary vulnerability. No significant differences were detected in patient characteristics, coronary angiographic findings, and OCT results between patients with higher and normal fibrinogen. Results of multivariate logistic analyses showed that diabetes and ACS were associated with TCFA, while diabetes, higher BMI, and ACS were associated with plaque rupture. Conclusions. Diabetes, higher BMI, and ACS are independently associated with coronary vulnerability as detected by OCT. Serum fibrinogen was not associated with coronary vulnerability in our cohort. |
| format | Article |
| id | doaj-art-e2c2aeda88a14276bfe2358f56591468 |
| institution | OA Journals |
| issn | 1755-5914 1755-5922 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
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| series | Cardiovascular Therapeutics |
| spelling | doaj-art-e2c2aeda88a14276bfe2358f565914682025-08-20T02:21:14ZengWileyCardiovascular Therapeutics1755-59141755-59222019-01-01201910.1155/2019/85637178563717New Insights into the Association between Fibrinogen and Coronary Atherosclerotic Plaque Vulnerability: An Intravascular Optical Coherence Tomography StudyJun Wang0Lu Jia1Xing Li2Siyu Jin3Xiaomei Li4Fen Liu5Chunfang Shan6Yu Zhang7Yining Yang8Department of Coronary Heart Disease, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, ChinaDepartment of Coronary Heart Disease, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, ChinaDepartment of Coronary Heart Disease, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, ChinaDepartment of Coronary Heart Disease, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, ChinaDepartment of Coronary Heart Disease, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, ChinaDepartment of Coronary Heart Disease, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, ChinaDepartment of Coronary Heart Disease, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, ChinaDepartment of Coronary Heart Disease, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, ChinaDepartment of Coronary Heart Disease, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, ChinaBackground. Fibrinogen levels have been associated with coronary plaque vulnerability in experimental studies. However, it has yet to be determined if serum fibrinogen levels are independently associated with coronary plaque vulnerability as detected by optical coherence tomography (OCT) in patients with coronary heart disease. Methods. Patients with coronary heart disease (CHD) who underwent coronary angiography and OCT in our department from January 2015 to August 2018 were included in this study. Coronary lesions were categorized as ruptured plaque, nonruptured with thin-cap fibroatheroma (TCFA), and nonruptured and non-TCFA. Presence of ruptured plaque and nonruptured with TCFA was considered to be vulnerable lesions. Determinants of coronary vulnerability were evaluated by multivariable logistic regression analyses. Results. A total of 154 patients were included in this study; 17 patients had ruptured plaques, 15 had nonruptured plaques with TCFA, and 122 had nonruptured plaques with non-TCFA. Results of univariate analyses showed that being male, diabetes, current smoking, high body mass index (BMI), and clinical diagnosis of acute coronary syndrome (ACS) were associated with coronary vulnerability. No significant differences were detected in patient characteristics, coronary angiographic findings, and OCT results between patients with higher and normal fibrinogen. Results of multivariate logistic analyses showed that diabetes and ACS were associated with TCFA, while diabetes, higher BMI, and ACS were associated with plaque rupture. Conclusions. Diabetes, higher BMI, and ACS are independently associated with coronary vulnerability as detected by OCT. Serum fibrinogen was not associated with coronary vulnerability in our cohort.http://dx.doi.org/10.1155/2019/8563717 |
| spellingShingle | Jun Wang Lu Jia Xing Li Siyu Jin Xiaomei Li Fen Liu Chunfang Shan Yu Zhang Yining Yang New Insights into the Association between Fibrinogen and Coronary Atherosclerotic Plaque Vulnerability: An Intravascular Optical Coherence Tomography Study Cardiovascular Therapeutics |
| title | New Insights into the Association between Fibrinogen and Coronary Atherosclerotic Plaque Vulnerability: An Intravascular Optical Coherence Tomography Study |
| title_full | New Insights into the Association between Fibrinogen and Coronary Atherosclerotic Plaque Vulnerability: An Intravascular Optical Coherence Tomography Study |
| title_fullStr | New Insights into the Association between Fibrinogen and Coronary Atherosclerotic Plaque Vulnerability: An Intravascular Optical Coherence Tomography Study |
| title_full_unstemmed | New Insights into the Association between Fibrinogen and Coronary Atherosclerotic Plaque Vulnerability: An Intravascular Optical Coherence Tomography Study |
| title_short | New Insights into the Association between Fibrinogen and Coronary Atherosclerotic Plaque Vulnerability: An Intravascular Optical Coherence Tomography Study |
| title_sort | new insights into the association between fibrinogen and coronary atherosclerotic plaque vulnerability an intravascular optical coherence tomography study |
| url | http://dx.doi.org/10.1155/2019/8563717 |
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