Childhood hand, foot and mouth disease sequelae cohort study in Henan, China: cohort profile
Purpose The childhood hand, foot and mouth disease (HFMD) sequelae cohort study (HNHFMDCS) is an ambispective cohort study of patients with HFMD based in Henan Province, China, consisting of patients treated in a key hospital for the diagnosis and treatment of HFMD in Henan Province. The study aims...
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BMJ Publishing Group
2025-01-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/15/1/e083958.full |
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| author | Chao Zhang Dong Li Yu Chen Fang Liu Fang Wang Xiaolong Li Kang Li Shuang Li Haiyan Yang Guangcai Duan Guowei Li Ling Tao Zhi Li Chenyu Wang Wenyi Liu Yaodong Zhang Wangquan Ji Huifen Feng Shouhang Chen Yuanfang Shen Jiaying Zheng Demin Feng Meili Sui Shuaiyin Chen Jinzhao Long Zhuangzhuang Wang Qingmei Wang Shujuan Han Bowen Dai Dejian Dang Peiyu Zhu Zijie Li Yuefei Jin |
| author_facet | Chao Zhang Dong Li Yu Chen Fang Liu Fang Wang Xiaolong Li Kang Li Shuang Li Haiyan Yang Guangcai Duan Guowei Li Ling Tao Zhi Li Chenyu Wang Wenyi Liu Yaodong Zhang Wangquan Ji Huifen Feng Shouhang Chen Yuanfang Shen Jiaying Zheng Demin Feng Meili Sui Shuaiyin Chen Jinzhao Long Zhuangzhuang Wang Qingmei Wang Shujuan Han Bowen Dai Dejian Dang Peiyu Zhu Zijie Li Yuefei Jin |
| author_sort | Chao Zhang |
| collection | DOAJ |
| description | Purpose The childhood hand, foot and mouth disease (HFMD) sequelae cohort study (HNHFMDCS) is an ambispective cohort study of patients with HFMD based in Henan Province, China, consisting of patients treated in a key hospital for the diagnosis and treatment of HFMD in Henan Province. The study aims to investigate the long-term sequelae of HFMD survivors and to provide a comprehensive understanding of the potential harm caused by this infectious disease.Participants In the retrospective phase of the cohort study, children diagnosed with HFMD from January 2014 to January 2023 were included, and clinical and demographic information about the patients was collected through a self-developed questionnaire. Patients hospitalised with HFMD since January 2023 were enrolled in the prospective cohort phase of the study, and long-term follow-up will be performed after completion of the baseline investigation (interview and comprehensive physical examination), clinical laboratory examination and biospecimen collection.Findings to date For the retrospective analysis of the cohort, a total of 18 705 HFMD cases (11 834 males and 6871 females) were observed between 2014 and 2022, of which 17 202 were mild cases (10 839 males and 6363 females) and 1503 were severe cases (995 males and 508 females). Statistical analysis was performed on the collected clinical examination data, and descriptive statistical methods, including mean value, SD and t-test, were used to compare the intergroup data. All tests were bilateral, and p<0.05 was considered statistically significant. There were significant differences in the hospitalisation duration and clinical examination indicators, such as platelets (PLT), C reactive protein (CRP), aspartate amino transferase (AST), alanine amino transferase (ALT), T lymphocyte subsets (CD3+ and CD3+CD4+) and B lymphocytes (CD19+) between mild and severe patients. The differences in these clinical examination indicators also help to detect changes in the disease in time so as to deeply understand the potential harm and social burden of the disease, and provide strong support for the rehabilitation of patients.Future plans Prospective cohort studies are currently underway, primarily enrolling hospitalised patients with HFMD to participate in our study. After the baseline investigation is completed, we will conduct long-term follow-up of the enrolled cases. In the coming year, we expect to obtain preliminary data on the incidence of sequelae in patients with HFMD 1–10 years after discharge, as well as information on the occurrence of sequelae. This dataset will be updated and expanded on an annual basis to support the continuous monitoring of patient health and disease progression. From HNHFMDCS, the study will provide a comprehensive overview of the potential harm caused by this common infectious disease, assess the social burden caused by this disease and make recommendations for the rehabilitation of survivors and prevention of further disability. |
| format | Article |
| id | doaj-art-e2bee6a37b1249ac99da29331e5dbc97 |
| institution | OA Journals |
| issn | 2044-6055 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-e2bee6a37b1249ac99da29331e5dbc972025-08-20T02:27:35ZengBMJ Publishing GroupBMJ Open2044-60552025-01-0115110.1136/bmjopen-2024-083958Childhood hand, foot and mouth disease sequelae cohort study in Henan, China: cohort profileChao Zhang0Dong Li1Yu Chen2Fang Liu3Fang Wang4Xiaolong Li5Kang Li6Shuang Li7Haiyan Yang8Guangcai Duan9Guowei Li10Ling Tao11Zhi Li12Chenyu Wang13Wenyi Liu14Yaodong Zhang15Wangquan Ji16Huifen Feng17Shouhang Chen18Yuanfang Shen19Jiaying Zheng20Demin Feng21Meili Sui22Shuaiyin Chen23Jinzhao Long24Zhuangzhuang Wang25Qingmei Wang26Shujuan Han27Bowen Dai28Dejian Dang29Peiyu Zhu30Zijie Li31Yuefei Jin326 The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China1 College of Public Health, Zhengzhou University, Zhengzhou, Henan, China1 College of Public Health, Zhengzhou University, Zhengzhou, Henan, China1 College of Public Health, Zhengzhou University, Zhengzhou, Henan, China2 Department of Infectious Diseases, Children’s Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan, China1 College of Public Health, Zhengzhou University, Zhengzhou, Henan, China1 College of Public Health, Zhengzhou University, Zhengzhou, Henan, China1 College of Public Health, Zhengzhou University, Zhengzhou, Henan, China1 College of Public Health, Zhengzhou University, Zhengzhou, Henan, China1 College of Public Health, Zhengzhou University, Zhengzhou, Henan, China7 Zhengzhou Center for Disease Control and Prevention, Zhengzhou, Henan, China4 Xinxiang Medical University, Xinxiang, Henan, China2 Department of Infectious Diseases, Children’s Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan, China2 Department of Infectious Diseases, Children’s Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan, China5 The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China2 Department of Infectious Diseases, Children’s Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan, China1 College of Public Health, Zhengzhou University, Zhengzhou, Henan, China3 The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China2 Department of Infectious Diseases, Children’s Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan, China2 Department of Infectious Diseases, Children’s Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan, China2 Department of Infectious Diseases, Children’s Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan, China5 The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China6 The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China1 College of Public Health, Zhengzhou University, Zhengzhou, Henan, China1 College of Public Health, Zhengzhou University, Zhengzhou, Henan, China2 Department of Infectious Diseases, Children’s Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan, China2 Department of Infectious Diseases, Children’s Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan, China2 Department of Infectious Diseases, Children’s Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan, China1 College of Public Health, Zhengzhou University, Zhengzhou, Henan, China3 The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China1 College of Public Health, Zhengzhou University, Zhengzhou, Henan, China1 College of Public Health, Zhengzhou University, Zhengzhou, Henan, China1 College of Public Health, Zhengzhou University, Zhengzhou, Henan, ChinaPurpose The childhood hand, foot and mouth disease (HFMD) sequelae cohort study (HNHFMDCS) is an ambispective cohort study of patients with HFMD based in Henan Province, China, consisting of patients treated in a key hospital for the diagnosis and treatment of HFMD in Henan Province. The study aims to investigate the long-term sequelae of HFMD survivors and to provide a comprehensive understanding of the potential harm caused by this infectious disease.Participants In the retrospective phase of the cohort study, children diagnosed with HFMD from January 2014 to January 2023 were included, and clinical and demographic information about the patients was collected through a self-developed questionnaire. Patients hospitalised with HFMD since January 2023 were enrolled in the prospective cohort phase of the study, and long-term follow-up will be performed after completion of the baseline investigation (interview and comprehensive physical examination), clinical laboratory examination and biospecimen collection.Findings to date For the retrospective analysis of the cohort, a total of 18 705 HFMD cases (11 834 males and 6871 females) were observed between 2014 and 2022, of which 17 202 were mild cases (10 839 males and 6363 females) and 1503 were severe cases (995 males and 508 females). Statistical analysis was performed on the collected clinical examination data, and descriptive statistical methods, including mean value, SD and t-test, were used to compare the intergroup data. All tests were bilateral, and p<0.05 was considered statistically significant. There were significant differences in the hospitalisation duration and clinical examination indicators, such as platelets (PLT), C reactive protein (CRP), aspartate amino transferase (AST), alanine amino transferase (ALT), T lymphocyte subsets (CD3+ and CD3+CD4+) and B lymphocytes (CD19+) between mild and severe patients. The differences in these clinical examination indicators also help to detect changes in the disease in time so as to deeply understand the potential harm and social burden of the disease, and provide strong support for the rehabilitation of patients.Future plans Prospective cohort studies are currently underway, primarily enrolling hospitalised patients with HFMD to participate in our study. After the baseline investigation is completed, we will conduct long-term follow-up of the enrolled cases. In the coming year, we expect to obtain preliminary data on the incidence of sequelae in patients with HFMD 1–10 years after discharge, as well as information on the occurrence of sequelae. This dataset will be updated and expanded on an annual basis to support the continuous monitoring of patient health and disease progression. From HNHFMDCS, the study will provide a comprehensive overview of the potential harm caused by this common infectious disease, assess the social burden caused by this disease and make recommendations for the rehabilitation of survivors and prevention of further disability.https://bmjopen.bmj.com/content/15/1/e083958.full |
| spellingShingle | Chao Zhang Dong Li Yu Chen Fang Liu Fang Wang Xiaolong Li Kang Li Shuang Li Haiyan Yang Guangcai Duan Guowei Li Ling Tao Zhi Li Chenyu Wang Wenyi Liu Yaodong Zhang Wangquan Ji Huifen Feng Shouhang Chen Yuanfang Shen Jiaying Zheng Demin Feng Meili Sui Shuaiyin Chen Jinzhao Long Zhuangzhuang Wang Qingmei Wang Shujuan Han Bowen Dai Dejian Dang Peiyu Zhu Zijie Li Yuefei Jin Childhood hand, foot and mouth disease sequelae cohort study in Henan, China: cohort profile BMJ Open |
| title | Childhood hand, foot and mouth disease sequelae cohort study in Henan, China: cohort profile |
| title_full | Childhood hand, foot and mouth disease sequelae cohort study in Henan, China: cohort profile |
| title_fullStr | Childhood hand, foot and mouth disease sequelae cohort study in Henan, China: cohort profile |
| title_full_unstemmed | Childhood hand, foot and mouth disease sequelae cohort study in Henan, China: cohort profile |
| title_short | Childhood hand, foot and mouth disease sequelae cohort study in Henan, China: cohort profile |
| title_sort | childhood hand foot and mouth disease sequelae cohort study in henan china cohort profile |
| url | https://bmjopen.bmj.com/content/15/1/e083958.full |
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