Angiotensin-Converting Enzyme Insertion/Deletion Gene Polymorphism in Chronic Rhinosinusitis with Nasal Polyps
Objective: Inflammatory processes play a role in the etiopathogenesis of chronic rhinosinusitis. Many gene polymorphisms have been associated with inflammation. In this study, we aimed to examine the relationship between angiotensin-converting enzyme insertion/deletion gene polymorphism and chronic...
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| Format: | Article |
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Galenos Yayincilik
2024-09-01
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| Series: | Turkish Archives of Otorhinolaryngology |
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| Online Access: | https://www.turkarchotolaryngol.net/articles/angiotensin-converting-enzyme-insertiondeletion-gene-polymorphism-in-chronic-rhinosinusitis-with-nasal-polyps/doi/tao.2024.2024-4-4 |
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| author | Mehmet Emre Sivrice Vural Akın Hasan Yasan Kuyaş Hekimler Öztürk Yusuf Çağdaş Kumbul |
| author_facet | Mehmet Emre Sivrice Vural Akın Hasan Yasan Kuyaş Hekimler Öztürk Yusuf Çağdaş Kumbul |
| author_sort | Mehmet Emre Sivrice |
| collection | DOAJ |
| description | Objective: Inflammatory processes play a role in the etiopathogenesis of chronic rhinosinusitis. Many gene polymorphisms have been associated with inflammation. In this study, we aimed to examine the relationship between angiotensin-converting enzyme insertion/deletion gene polymorphism and chronic rhinosinusitis.
Methods: Fifty-two cases with nasal polyps and 139 control patients were included in the study. Angiotensin-converting enzyme insertion/deletion gene polymorphisms, genotype, and allele distributions were determined. Results were statistically compared between groups.
Results: Statistically significant differences were found between the chronic rhinosinusitis with nasal polyps group and the control group in terms of genotype and allele distribution (p=0.015, 0.003, respectively). There were no significant differences in genotype distribution in the chronic rhinosinusitis with nasal polyps group in terms of non-steroidal anti-inflammatory drug (NSAID) allergy, asthma, and NSAID-exacerbated respiratory disease (p=0.645, 0.660, 0.095, respectively).
Conclusion: We observed that the risk of chronic rhinosinusitis is higher in individuals with the deletion-deletion genotype and D allele of the angiotensin-converting enzyme insertion/deletion gene polymorphism. We believe that these results could be related to the high angiotensin-converting enzyme levels in these patients. |
| format | Article |
| id | doaj-art-e2b621f30fcc465f94c350796c80f7ff |
| institution | Kabale University |
| issn | 2667-7474 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Galenos Yayincilik |
| record_format | Article |
| series | Turkish Archives of Otorhinolaryngology |
| spelling | doaj-art-e2b621f30fcc465f94c350796c80f7ff2025-01-14T08:33:28ZengGalenos YayincilikTurkish Archives of Otorhinolaryngology2667-74742024-09-016239510010.4274/tao.2024.2024-4-4Angiotensin-Converting Enzyme Insertion/Deletion Gene Polymorphism in Chronic Rhinosinusitis with Nasal PolypsMehmet Emre Sivrice0https://orcid.org/0000-0002-2396-6794Vural Akın1https://orcid.org/0000-0002-0050-4837Hasan Yasan2https://orcid.org/0000-0002-5470-6784Kuyaş Hekimler Öztürk3https://orcid.org/0000-0002-7075-8875Yusuf Çağdaş Kumbul4https://orcid.org/0000-0002-0713-2933Süleyman Demirel University Faculty of Medicine, Department of Otorhinolaryngology and Head & Neck Surgery, Isparta, TürkiyeYüksekova State Hospital, Department of Otorhinolaryngology and Head & Neck Surgery, Hakkari, TürkiyeSüleyman Demirel University Faculty of Medicine, Department of Otorhinolaryngology and Head & Neck Surgery, Isparta, TürkiyeSüleyman Demirel University Faculty of Medicine, Department of Medical Genetics, Isparta, TürkiyeYüksekova State Hospital, Department of Otorhinolaryngology and Head & Neck Surgery, Hakkari, TürkiyeObjective: Inflammatory processes play a role in the etiopathogenesis of chronic rhinosinusitis. Many gene polymorphisms have been associated with inflammation. In this study, we aimed to examine the relationship between angiotensin-converting enzyme insertion/deletion gene polymorphism and chronic rhinosinusitis. Methods: Fifty-two cases with nasal polyps and 139 control patients were included in the study. Angiotensin-converting enzyme insertion/deletion gene polymorphisms, genotype, and allele distributions were determined. Results were statistically compared between groups. Results: Statistically significant differences were found between the chronic rhinosinusitis with nasal polyps group and the control group in terms of genotype and allele distribution (p=0.015, 0.003, respectively). There were no significant differences in genotype distribution in the chronic rhinosinusitis with nasal polyps group in terms of non-steroidal anti-inflammatory drug (NSAID) allergy, asthma, and NSAID-exacerbated respiratory disease (p=0.645, 0.660, 0.095, respectively). Conclusion: We observed that the risk of chronic rhinosinusitis is higher in individuals with the deletion-deletion genotype and D allele of the angiotensin-converting enzyme insertion/deletion gene polymorphism. We believe that these results could be related to the high angiotensin-converting enzyme levels in these patients.https://www.turkarchotolaryngol.net/articles/angiotensin-converting-enzyme-insertiondeletion-gene-polymorphism-in-chronic-rhinosinusitis-with-nasal-polyps/doi/tao.2024.2024-4-4sinusitisnasal polypsgene polymorphisminflammationangiotensin-converting enzymegenetic association studiesnon-steroidal anti-inflammatory agents |
| spellingShingle | Mehmet Emre Sivrice Vural Akın Hasan Yasan Kuyaş Hekimler Öztürk Yusuf Çağdaş Kumbul Angiotensin-Converting Enzyme Insertion/Deletion Gene Polymorphism in Chronic Rhinosinusitis with Nasal Polyps Turkish Archives of Otorhinolaryngology sinusitis nasal polyps gene polymorphism inflammation angiotensin-converting enzyme genetic association studies non-steroidal anti-inflammatory agents |
| title | Angiotensin-Converting Enzyme Insertion/Deletion Gene Polymorphism in Chronic Rhinosinusitis with Nasal Polyps |
| title_full | Angiotensin-Converting Enzyme Insertion/Deletion Gene Polymorphism in Chronic Rhinosinusitis with Nasal Polyps |
| title_fullStr | Angiotensin-Converting Enzyme Insertion/Deletion Gene Polymorphism in Chronic Rhinosinusitis with Nasal Polyps |
| title_full_unstemmed | Angiotensin-Converting Enzyme Insertion/Deletion Gene Polymorphism in Chronic Rhinosinusitis with Nasal Polyps |
| title_short | Angiotensin-Converting Enzyme Insertion/Deletion Gene Polymorphism in Chronic Rhinosinusitis with Nasal Polyps |
| title_sort | angiotensin converting enzyme insertion deletion gene polymorphism in chronic rhinosinusitis with nasal polyps |
| topic | sinusitis nasal polyps gene polymorphism inflammation angiotensin-converting enzyme genetic association studies non-steroidal anti-inflammatory agents |
| url | https://www.turkarchotolaryngol.net/articles/angiotensin-converting-enzyme-insertiondeletion-gene-polymorphism-in-chronic-rhinosinusitis-with-nasal-polyps/doi/tao.2024.2024-4-4 |
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