Associative connection of infectious and inflammatory diseases in pregnancy and severe preeclampsia
Materials and methods. This retrospective case-control study enrolled 50 women with severe preeclampsia and 50 control women with spontaneous singleton pregnancy. Median age of women ranged from 20 to 35 years. All women did not have a history of hypertension, autoimmune, metabolic, renal, or cardia...
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| Format: | Article |
| Language: | Russian |
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Scientific Сentre for Family Health and Human Reproduction Problems
2018-05-01
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| Series: | Acta Biomedica Scientifica |
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| Online Access: | https://www.actabiomedica.ru/jour/article/view/577 |
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| author | T. E. Belokrinitskaya N. I. Frolova L. I. Anokhova K. A. Kolmakova V. A. Pletnyova O. Y. Brum O. A. Li O.a A. S. Karaseva O. A. Staritsyna |
| author_facet | T. E. Belokrinitskaya N. I. Frolova L. I. Anokhova K. A. Kolmakova V. A. Pletnyova O. Y. Brum O. A. Li O.a A. S. Karaseva O. A. Staritsyna |
| author_sort | T. E. Belokrinitskaya |
| collection | DOAJ |
| description | Materials and methods. This retrospective case-control study enrolled 50 women with severe preeclampsia and 50 control women with spontaneous singleton pregnancy. Median age of women ranged from 20 to 35 years. All women did not have a history of hypertension, autoimmune, metabolic, renal, or cardiac diseases, and preeclampsia before this pregnancy. We have analyzed χ2, odds ratio (OR) and its 95% confidence intervals (95% Cl). Results. We found significant association between maternal systemic infectious and severe preeclampsia (OR = 49.6; 95% Cl 13.05-188.64). The risk of severe preeclampsia were significantly lower in patients with local infections of the lower genital tract (OR = 4.5; 95% Cl 1.49-6.71). Asymptomatic bacteriuria is associated with the highest risk of severe preeclampsia (OR = 17.0; 95% Cl 4.66-61.81). Acute gravidarum pyelonephritis showed lower association with severe preeclampsia (OR = 5.4; 95% Cl 1.69-10.54). We did not observe increased risk of severe preeclampsia with acute respiratory infections (OR = 2.0; 95% Cl 0.71-4.69). Acute non-specific bacterial vaginitis and acute candidiasis vulvovaginitis were found to be risk factors of severe preeclampsia (OR = 6.7; 95% Cl 1.90-11.02 and OR = 4.3; 95% Cl 1.45-9.99 respectively). Cytomegalovirus infection (2 %), toxoplasmosis (2 %), Chlamydia trachomatis cervicitis (4 %), acute Trichomonas colpitis (2 %) and bacterial vaginosis (4 %) were found only in patients with severe preeclampsia. Conclusion. Our data support that acute maternal infection is associated with an increased risk of severe preeclampsia in healthy women with singleton pregnancy. Systemic inflammatory response might be the main potential mechanisms related to infections and enhanced development of severe preeclampsia. Further research is required to elucidate the underlying mechanism of this association. |
| format | Article |
| id | doaj-art-e2b38dbfb03142f187824948f152b1c5 |
| institution | Kabale University |
| issn | 2541-9420 2587-9596 |
| language | Russian |
| publishDate | 2018-05-01 |
| publisher | Scientific Сentre for Family Health and Human Reproduction Problems |
| record_format | Article |
| series | Acta Biomedica Scientifica |
| spelling | doaj-art-e2b38dbfb03142f187824948f152b1c52025-08-20T03:56:54ZrusScientific Сentre for Family Health and Human Reproduction ProblemsActa Biomedica Scientifica2541-94202587-95962018-05-013391410.29413/ABS.2018-3.3.1577Associative connection of infectious and inflammatory diseases in pregnancy and severe preeclampsiaT. E. Belokrinitskaya0N. I. Frolova1L. I. Anokhova2K. A. Kolmakova3V. A. Pletnyova4O. Y. Brum5O. A. Li O.a6A. S. Karaseva7O. A. Staritsyna8Chita State Medical AcademyChita State Medical AcademyChita State Medical AcademyChita State Medical AcademyChita State Medical AcademyZabaikalskiy Regional Perinatal CenterZabaikalskiy Regional Perinatal CenterZabaikalskiy Regional Perinatal CenterZabaikalskiy Regional Perinatal CenternMaterials and methods. This retrospective case-control study enrolled 50 women with severe preeclampsia and 50 control women with spontaneous singleton pregnancy. Median age of women ranged from 20 to 35 years. All women did not have a history of hypertension, autoimmune, metabolic, renal, or cardiac diseases, and preeclampsia before this pregnancy. We have analyzed χ2, odds ratio (OR) and its 95% confidence intervals (95% Cl). Results. We found significant association between maternal systemic infectious and severe preeclampsia (OR = 49.6; 95% Cl 13.05-188.64). The risk of severe preeclampsia were significantly lower in patients with local infections of the lower genital tract (OR = 4.5; 95% Cl 1.49-6.71). Asymptomatic bacteriuria is associated with the highest risk of severe preeclampsia (OR = 17.0; 95% Cl 4.66-61.81). Acute gravidarum pyelonephritis showed lower association with severe preeclampsia (OR = 5.4; 95% Cl 1.69-10.54). We did not observe increased risk of severe preeclampsia with acute respiratory infections (OR = 2.0; 95% Cl 0.71-4.69). Acute non-specific bacterial vaginitis and acute candidiasis vulvovaginitis were found to be risk factors of severe preeclampsia (OR = 6.7; 95% Cl 1.90-11.02 and OR = 4.3; 95% Cl 1.45-9.99 respectively). Cytomegalovirus infection (2 %), toxoplasmosis (2 %), Chlamydia trachomatis cervicitis (4 %), acute Trichomonas colpitis (2 %) and bacterial vaginosis (4 %) were found only in patients with severe preeclampsia. Conclusion. Our data support that acute maternal infection is associated with an increased risk of severe preeclampsia in healthy women with singleton pregnancy. Systemic inflammatory response might be the main potential mechanisms related to infections and enhanced development of severe preeclampsia. Further research is required to elucidate the underlying mechanism of this association.https://www.actabiomedica.ru/jour/article/view/577preeclampsiamaternal infectionsystemic inflammatory response |
| spellingShingle | T. E. Belokrinitskaya N. I. Frolova L. I. Anokhova K. A. Kolmakova V. A. Pletnyova O. Y. Brum O. A. Li O.a A. S. Karaseva O. A. Staritsyna Associative connection of infectious and inflammatory diseases in pregnancy and severe preeclampsia Acta Biomedica Scientifica preeclampsia maternal infection systemic inflammatory response |
| title | Associative connection of infectious and inflammatory diseases in pregnancy and severe preeclampsia |
| title_full | Associative connection of infectious and inflammatory diseases in pregnancy and severe preeclampsia |
| title_fullStr | Associative connection of infectious and inflammatory diseases in pregnancy and severe preeclampsia |
| title_full_unstemmed | Associative connection of infectious and inflammatory diseases in pregnancy and severe preeclampsia |
| title_short | Associative connection of infectious and inflammatory diseases in pregnancy and severe preeclampsia |
| title_sort | associative connection of infectious and inflammatory diseases in pregnancy and severe preeclampsia |
| topic | preeclampsia maternal infection systemic inflammatory response |
| url | https://www.actabiomedica.ru/jour/article/view/577 |
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