The miR-941/FOXN4/TGF-β feedback loop induces N2 polarization of neutrophils and enhances tumor progression of lung adenocarcinoma

The miR-941/FOXN4/TGF-β feedback loop induces N2 polarization of neutrophils and enhances tumor progression of lung adenocarcinoma

BackgroundLung adenocarcinoma (LUAD) is a major subtype of lung cancer and one of the deadliest cancers in humans. Dysregulation of miRNA activity in tumor-associated neutrophils (TANs) in the tumor microenvironment plays an important role in the occurrence and development of LUAD.MethodIn this stud...

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Bibliographic Details
Main Authors: Xiaojing Zhang, Xitong Huang, Xianying Zhang, Lichang Lai, Baoyi Zhu, Peibin Lin, Zhanfang Kang, Dazhong Yin, Dongbo Tian, Zisheng Chen, Jun Gao
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Immunology
Subjects:
lung adenocarcinoma (LUAD)
single-cell RNA sequencing (scRNA-seq)
tumor-associated neutrophils (TANs)
miR-941
Foxn4
TGF-b
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1561081/full
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