Heart rate variability in schizophrenia: A comparative analysis before and after electroconvulsive therapy
Abstract Aim The aim of this study was to investigate autonomic nervous system imbalance in schizophrenia by comparing heart rate variability (HRV) between patients with schizophrenia and healthy controls, and to assess changes in HRV in patients before and after electroconvulsive therapy (ECT). Met...
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| Format: | Article |
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Wiley
2024-12-01
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| Series: | PCN Reports |
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| Online Access: | https://doi.org/10.1002/pcn5.70030 |
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| author | Noriko Yoshida Miho Miyajima Yoko Suzuki Eisuke Matsushima Takafumi Watanabe Rie Omoya Mayo Fujiwara Mitsuru Nakamura Hidehiko Takahashi Takashi Takeuchi |
| author_facet | Noriko Yoshida Miho Miyajima Yoko Suzuki Eisuke Matsushima Takafumi Watanabe Rie Omoya Mayo Fujiwara Mitsuru Nakamura Hidehiko Takahashi Takashi Takeuchi |
| author_sort | Noriko Yoshida |
| collection | DOAJ |
| description | Abstract Aim The aim of this study was to investigate autonomic nervous system imbalance in schizophrenia by comparing heart rate variability (HRV) between patients with schizophrenia and healthy controls, and to assess changes in HRV in patients before and after electroconvulsive therapy (ECT). Methods HRV was compared between patients with schizophrenia (n = 17) and age‐ and gender‐matched healthy controls (n = 34). Changes in HRV were also assessed in patients pre‐ and post‐ECT. Additionally, the relationship between HRV and Positive and Negative Symptom Scale (PANSS) scores in patients with schizophrenia was investigated. Results Patients with schizophrenia showed significantly lower high‐frequency (HF) and low‐frequency (LF) power compared with healthy controls, with a trend towards a higher LF/HF ratio. Following ECT, HF power increased significantly while the LF/HF ratio decreased significantly, resulting in no significant differences between patients and controls for these HRV parameters. The associations between HRV and symptoms observed before ECT were largely diminished after ECT, with only changes in the LF component correlating with changes in PANSS scores. Conclusion Following ECT, we observed a shift in autonomic balance from sympathetic dominance towards increased parasympathetic activity and a state more closely resembling that in healthy controls. |
| format | Article |
| id | doaj-art-e2aca930daea422a9fe6de3d96f34271 |
| institution | Kabale University |
| issn | 2769-2558 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | PCN Reports |
| spelling | doaj-art-e2aca930daea422a9fe6de3d96f342712025-01-03T11:15:26ZengWileyPCN Reports2769-25582024-12-0134n/an/a10.1002/pcn5.70030Heart rate variability in schizophrenia: A comparative analysis before and after electroconvulsive therapyNoriko Yoshida0Miho Miyajima1Yoko Suzuki2Eisuke Matsushima3Takafumi Watanabe4Rie Omoya5Mayo Fujiwara6Mitsuru Nakamura7Hidehiko Takahashi8Takashi Takeuchi9Narimasu Kosei Hospital Tokyo JapanDepartment of Psychiatry and Behavioral Sciences, Graduate School of Medical and Dental Sciences Liaison Psychiatry and Psycho‐Oncology Unit, Institute of Science Tokyo Tokyo JapanInternational Institute for Integrative Sleep Medicine (WPI‐IIIS), University of Tsukuba Tokyo JapanDepartment of Psychiatry and Behavioral Sciences, Graduate School of Medical and Dental Sciences Institute of Science Tokyo Tokyo JapanNarimasu Kosei Hospital Tokyo JapanTokyo Metropolitan Health and Medical Corporation Toshima Hospital Tokyo JapanHiratsuka Hospital Tokyo JapanNarimasu Kosei Hospital Tokyo JapanDepartment of Psychiatry and Behavioral Sciences, Graduate School of Medical and Dental Sciences Institute of Science Tokyo Tokyo JapanDepartment of Psychiatry and Behavioral Sciences, Graduate School of Medical and Dental Sciences Liaison Psychiatry and Psycho‐Oncology Unit, Institute of Science Tokyo Tokyo JapanAbstract Aim The aim of this study was to investigate autonomic nervous system imbalance in schizophrenia by comparing heart rate variability (HRV) between patients with schizophrenia and healthy controls, and to assess changes in HRV in patients before and after electroconvulsive therapy (ECT). Methods HRV was compared between patients with schizophrenia (n = 17) and age‐ and gender‐matched healthy controls (n = 34). Changes in HRV were also assessed in patients pre‐ and post‐ECT. Additionally, the relationship between HRV and Positive and Negative Symptom Scale (PANSS) scores in patients with schizophrenia was investigated. Results Patients with schizophrenia showed significantly lower high‐frequency (HF) and low‐frequency (LF) power compared with healthy controls, with a trend towards a higher LF/HF ratio. Following ECT, HF power increased significantly while the LF/HF ratio decreased significantly, resulting in no significant differences between patients and controls for these HRV parameters. The associations between HRV and symptoms observed before ECT were largely diminished after ECT, with only changes in the LF component correlating with changes in PANSS scores. Conclusion Following ECT, we observed a shift in autonomic balance from sympathetic dominance towards increased parasympathetic activity and a state more closely resembling that in healthy controls.https://doi.org/10.1002/pcn5.70030autonomic imbalanceautonomic nervous system dysfunctionelectroconvulsive therapyreduced parasympathetic activityschizophrenia |
| spellingShingle | Noriko Yoshida Miho Miyajima Yoko Suzuki Eisuke Matsushima Takafumi Watanabe Rie Omoya Mayo Fujiwara Mitsuru Nakamura Hidehiko Takahashi Takashi Takeuchi Heart rate variability in schizophrenia: A comparative analysis before and after electroconvulsive therapy PCN Reports autonomic imbalance autonomic nervous system dysfunction electroconvulsive therapy reduced parasympathetic activity schizophrenia |
| title | Heart rate variability in schizophrenia: A comparative analysis before and after electroconvulsive therapy |
| title_full | Heart rate variability in schizophrenia: A comparative analysis before and after electroconvulsive therapy |
| title_fullStr | Heart rate variability in schizophrenia: A comparative analysis before and after electroconvulsive therapy |
| title_full_unstemmed | Heart rate variability in schizophrenia: A comparative analysis before and after electroconvulsive therapy |
| title_short | Heart rate variability in schizophrenia: A comparative analysis before and after electroconvulsive therapy |
| title_sort | heart rate variability in schizophrenia a comparative analysis before and after electroconvulsive therapy |
| topic | autonomic imbalance autonomic nervous system dysfunction electroconvulsive therapy reduced parasympathetic activity schizophrenia |
| url | https://doi.org/10.1002/pcn5.70030 |
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