Comparative effects of moderate and high-intensity training on immune activation in myocarditis: a review of preclinical and clinical evidence
Exercise intensity plays a critical role in influencing immune responses during myocarditis, a condition characterized by inflammation of the cardiac tissue. Based on preclinical and clinical evidence, this review examines how moderate versus high-intensity training affects immune activation in myoc...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-08-01
|
| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1643056/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849233703868301312 |
|---|---|
| author | Bartolo Ferraro Bartolo Ferraro Cristina Alejandra Buela Alvarado Cristina Alejandra Buela Alvarado Jonas Mink Jonas Mink Ludwig T. Weckbach Ludwig T. Weckbach Ludwig T. Weckbach Ludwig T. Weckbach |
| author_facet | Bartolo Ferraro Bartolo Ferraro Cristina Alejandra Buela Alvarado Cristina Alejandra Buela Alvarado Jonas Mink Jonas Mink Ludwig T. Weckbach Ludwig T. Weckbach Ludwig T. Weckbach Ludwig T. Weckbach |
| author_sort | Bartolo Ferraro |
| collection | DOAJ |
| description | Exercise intensity plays a critical role in influencing immune responses during myocarditis, a condition characterized by inflammation of the cardiac tissue. Based on preclinical and clinical evidence, this review examines how moderate versus high-intensity training affects immune activation in myocarditis. Studies involving animals suggest that moderate exercise may reduce inflammation and support immune regulation, while high-intensity training often exacerbates pro-inflammatory responses and worsens cardiac injury. Limited clinical data support these findings, indicating that moderate exercise could be safe or even beneficial in stable cases, whereas high-intensity exercise poses risks, particularly during active disease. Understanding these contrasting effects is essential for developing exercise recommendations for patients with myocarditis, balancing the need for recovery with immune safety. Further research is necessary to identify optimal exercise strategies for this vulnerable population. |
| format | Article |
| id | doaj-art-e2abfea4c456432c8ec2d322bbdbce35 |
| institution | Kabale University |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-e2abfea4c456432c8ec2d322bbdbce352025-08-20T04:14:10ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-08-011610.3389/fphar.2025.16430561643056Comparative effects of moderate and high-intensity training on immune activation in myocarditis: a review of preclinical and clinical evidenceBartolo Ferraro0Bartolo Ferraro1Cristina Alejandra Buela Alvarado2Cristina Alejandra Buela Alvarado3Jonas Mink4Jonas Mink5Ludwig T. Weckbach6Ludwig T. Weckbach7Ludwig T. Weckbach8Ludwig T. Weckbach9Institute of Cardiovascular Physiology and Pathophysiology, Biomedical Center, Ludwig- Maximilian-University Munich, Munich, GermanyMedizinische Klinik und Poliklinik I, Klinikum der Universität, Ludwig-Maximilians-University Munich, Munich, GermanyInstitute of Cardiovascular Physiology and Pathophysiology, Biomedical Center, Ludwig- Maximilian-University Munich, Munich, GermanyMedizinische Klinik und Poliklinik I, Klinikum der Universität, Ludwig-Maximilians-University Munich, Munich, GermanyInstitute of Cardiovascular Physiology and Pathophysiology, Biomedical Center, Ludwig- Maximilian-University Munich, Munich, GermanyMedizinische Klinik und Poliklinik I, Klinikum der Universität, Ludwig-Maximilians-University Munich, Munich, GermanyInstitute of Cardiovascular Physiology and Pathophysiology, Biomedical Center, Ludwig- Maximilian-University Munich, Munich, GermanyMedizinische Klinik und Poliklinik I, Klinikum der Universität, Ludwig-Maximilians-University Munich, Munich, GermanyWalter Brendel Centre of Experimental Medicine, Ludwig-Maximilians-University Munich, University Hospital, Munich, GermanyDZHK, Partner Site Munich Heart Alliance, Munich, GermanyExercise intensity plays a critical role in influencing immune responses during myocarditis, a condition characterized by inflammation of the cardiac tissue. Based on preclinical and clinical evidence, this review examines how moderate versus high-intensity training affects immune activation in myocarditis. Studies involving animals suggest that moderate exercise may reduce inflammation and support immune regulation, while high-intensity training often exacerbates pro-inflammatory responses and worsens cardiac injury. Limited clinical data support these findings, indicating that moderate exercise could be safe or even beneficial in stable cases, whereas high-intensity exercise poses risks, particularly during active disease. Understanding these contrasting effects is essential for developing exercise recommendations for patients with myocarditis, balancing the need for recovery with immune safety. Further research is necessary to identify optimal exercise strategies for this vulnerable population.https://www.frontiersin.org/articles/10.3389/fphar.2025.1643056/fullmyocarditisimmune cell activation/modulationmoderate intensity activityhigh intensity activityclinical studiespreclinical studies |
| spellingShingle | Bartolo Ferraro Bartolo Ferraro Cristina Alejandra Buela Alvarado Cristina Alejandra Buela Alvarado Jonas Mink Jonas Mink Ludwig T. Weckbach Ludwig T. Weckbach Ludwig T. Weckbach Ludwig T. Weckbach Comparative effects of moderate and high-intensity training on immune activation in myocarditis: a review of preclinical and clinical evidence Frontiers in Pharmacology myocarditis immune cell activation/modulation moderate intensity activity high intensity activity clinical studies preclinical studies |
| title | Comparative effects of moderate and high-intensity training on immune activation in myocarditis: a review of preclinical and clinical evidence |
| title_full | Comparative effects of moderate and high-intensity training on immune activation in myocarditis: a review of preclinical and clinical evidence |
| title_fullStr | Comparative effects of moderate and high-intensity training on immune activation in myocarditis: a review of preclinical and clinical evidence |
| title_full_unstemmed | Comparative effects of moderate and high-intensity training on immune activation in myocarditis: a review of preclinical and clinical evidence |
| title_short | Comparative effects of moderate and high-intensity training on immune activation in myocarditis: a review of preclinical and clinical evidence |
| title_sort | comparative effects of moderate and high intensity training on immune activation in myocarditis a review of preclinical and clinical evidence |
| topic | myocarditis immune cell activation/modulation moderate intensity activity high intensity activity clinical studies preclinical studies |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1643056/full |
| work_keys_str_mv | AT bartoloferraro comparativeeffectsofmoderateandhighintensitytrainingonimmuneactivationinmyocarditisareviewofpreclinicalandclinicalevidence AT bartoloferraro comparativeeffectsofmoderateandhighintensitytrainingonimmuneactivationinmyocarditisareviewofpreclinicalandclinicalevidence AT cristinaalejandrabuelaalvarado comparativeeffectsofmoderateandhighintensitytrainingonimmuneactivationinmyocarditisareviewofpreclinicalandclinicalevidence AT cristinaalejandrabuelaalvarado comparativeeffectsofmoderateandhighintensitytrainingonimmuneactivationinmyocarditisareviewofpreclinicalandclinicalevidence AT jonasmink comparativeeffectsofmoderateandhighintensitytrainingonimmuneactivationinmyocarditisareviewofpreclinicalandclinicalevidence AT jonasmink comparativeeffectsofmoderateandhighintensitytrainingonimmuneactivationinmyocarditisareviewofpreclinicalandclinicalevidence AT ludwigtweckbach comparativeeffectsofmoderateandhighintensitytrainingonimmuneactivationinmyocarditisareviewofpreclinicalandclinicalevidence AT ludwigtweckbach comparativeeffectsofmoderateandhighintensitytrainingonimmuneactivationinmyocarditisareviewofpreclinicalandclinicalevidence AT ludwigtweckbach comparativeeffectsofmoderateandhighintensitytrainingonimmuneactivationinmyocarditisareviewofpreclinicalandclinicalevidence AT ludwigtweckbach comparativeeffectsofmoderateandhighintensitytrainingonimmuneactivationinmyocarditisareviewofpreclinicalandclinicalevidence |