Evaluating Vascular Hemodynamics in Cerebral Proliferative Angiopathy Using Advanced Arterial Spin Labeling MRI
Cerebral proliferative angiopathy (CPA) is a rare vascular disorder that affects normal blood circulation in the brain. Although the structural changes in CPA can be characterized using standard radiologic modalities, assessing the vascular hemodynamics in patients with CPA remains challenging due t...
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| Format: | Article |
| Language: | English |
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Wiley
2025-03-01
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| Series: | Stroke: Vascular and Interventional Neurology |
| Online Access: | https://www.ahajournals.org/doi/10.1161/SVIN.124.001552 |
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| author | Rui Duarte Armindo Moss Zhao Sasha Alexander Elizabeth Tong Kristen Yeom Michael Moseley Pedro Vilela Gary Steinberg |
| author_facet | Rui Duarte Armindo Moss Zhao Sasha Alexander Elizabeth Tong Kristen Yeom Michael Moseley Pedro Vilela Gary Steinberg |
| author_sort | Rui Duarte Armindo |
| collection | DOAJ |
| description | Cerebral proliferative angiopathy (CPA) is a rare vascular disorder that affects normal blood circulation in the brain. Although the structural changes in CPA can be characterized using standard radiologic modalities, assessing the vascular hemodynamics in patients with CPA remains challenging due to inadequate imaging technologies. Arterial spin labeling (ASL) is a noninvasive magnetic resonance technique that allows quantitative assessments of cerebral blood flow. ASL with multiple labeling delays (multidelay ASL) also enables the quantification of arterial transit time. Here, we report the first application of multidelay ASL in a patient with CPA before and after bypass surgery. Our study demonstrated that ASL can be effectively applied to evaluating hemodynamic changes in patients with CPA. Our quantitative results indicated that, in regions affected by CPA, cerebral blood flow increased by at least 14% and arterial transit time decreased by 9.4% after bypass surgery. |
| format | Article |
| id | doaj-art-e2aa2a6610154233af04ccdec320881e |
| institution | DOAJ |
| issn | 2694-5746 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stroke: Vascular and Interventional Neurology |
| spelling | doaj-art-e2aa2a6610154233af04ccdec320881e2025-08-20T03:17:32ZengWileyStroke: Vascular and Interventional Neurology2694-57462025-03-015210.1161/SVIN.124.001552Evaluating Vascular Hemodynamics in Cerebral Proliferative Angiopathy Using Advanced Arterial Spin Labeling MRIRui Duarte Armindo0Moss Zhao1Sasha Alexander2Elizabeth Tong3Kristen Yeom4Michael Moseley5Pedro Vilela6Gary Steinberg7Department of Neuroradiology Western Lisbon Hospital Center Lisbon PortugalDepartment of Neurosurgery Stanford University Stanford CADepartment of Neurosurgery Stanford University Stanford CADepartment of Radiology Stanford University Stanford CADepartment of Radiology Phoenix Children's Hospital Phoenix AZDepartment of Radiology Stanford University Stanford CADepartment of Neuroradiology Western Lisbon Hospital Center Lisbon PortugalDepartment of Neurosurgery Stanford University Stanford CACerebral proliferative angiopathy (CPA) is a rare vascular disorder that affects normal blood circulation in the brain. Although the structural changes in CPA can be characterized using standard radiologic modalities, assessing the vascular hemodynamics in patients with CPA remains challenging due to inadequate imaging technologies. Arterial spin labeling (ASL) is a noninvasive magnetic resonance technique that allows quantitative assessments of cerebral blood flow. ASL with multiple labeling delays (multidelay ASL) also enables the quantification of arterial transit time. Here, we report the first application of multidelay ASL in a patient with CPA before and after bypass surgery. Our study demonstrated that ASL can be effectively applied to evaluating hemodynamic changes in patients with CPA. Our quantitative results indicated that, in regions affected by CPA, cerebral blood flow increased by at least 14% and arterial transit time decreased by 9.4% after bypass surgery.https://www.ahajournals.org/doi/10.1161/SVIN.124.001552 |
| spellingShingle | Rui Duarte Armindo Moss Zhao Sasha Alexander Elizabeth Tong Kristen Yeom Michael Moseley Pedro Vilela Gary Steinberg Evaluating Vascular Hemodynamics in Cerebral Proliferative Angiopathy Using Advanced Arterial Spin Labeling MRI Stroke: Vascular and Interventional Neurology |
| title | Evaluating Vascular Hemodynamics in Cerebral Proliferative Angiopathy Using Advanced Arterial Spin Labeling MRI |
| title_full | Evaluating Vascular Hemodynamics in Cerebral Proliferative Angiopathy Using Advanced Arterial Spin Labeling MRI |
| title_fullStr | Evaluating Vascular Hemodynamics in Cerebral Proliferative Angiopathy Using Advanced Arterial Spin Labeling MRI |
| title_full_unstemmed | Evaluating Vascular Hemodynamics in Cerebral Proliferative Angiopathy Using Advanced Arterial Spin Labeling MRI |
| title_short | Evaluating Vascular Hemodynamics in Cerebral Proliferative Angiopathy Using Advanced Arterial Spin Labeling MRI |
| title_sort | evaluating vascular hemodynamics in cerebral proliferative angiopathy using advanced arterial spin labeling mri |
| url | https://www.ahajournals.org/doi/10.1161/SVIN.124.001552 |
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