A Unique Case of Fungal Endometritis Caused by Aspergillus quadrilineatus in an Immunocompetent Woman and Literature Review
ABSTRACT Abnormal uterine bleeding (AUB) is a common gynecological concern often attributed to hormonal disorders, malignancies, or infections. While bacterial and viral infections are frequently investigated, fungal infections, such as aspergillosis, are often overlooked. This case report highlight...
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| Format: | Article |
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Wiley
2025-02-01
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| Series: | Clinical Case Reports |
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| Online Access: | https://doi.org/10.1002/ccr3.70146 |
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| author | Fatemeh Zahra Ranjbar Golafshani Erfan Ghaffari Lashkenari Firoozeh Kermani Soheila Abbaszadeh Godarzi Saeid Mahdavi Omran |
| author_facet | Fatemeh Zahra Ranjbar Golafshani Erfan Ghaffari Lashkenari Firoozeh Kermani Soheila Abbaszadeh Godarzi Saeid Mahdavi Omran |
| author_sort | Fatemeh Zahra Ranjbar Golafshani |
| collection | DOAJ |
| description | ABSTRACT Abnormal uterine bleeding (AUB) is a common gynecological concern often attributed to hormonal disorders, malignancies, or infections. While bacterial and viral infections are frequently investigated, fungal infections, such as aspergillosis, are often overlooked. This case report highlights a rare instance of endometrial aspergillosis caused by Aspergillus quadrilineatus in an immunocompetent woman. A 64‐year‐old woman presented with persistent vaginal bleeding. Histopathological examination of endometrial tissue revealed septate hyphae consistent with fungal infection. Molecular analysis identified the causative agent as A. quadrilineatus. The A. quadrilineatus isolate demonstrated susceptibility to various antifungal agents, including azoles and amphotericin B. This report emphasizes the need for increased awareness of fungal infections, including aspergillosis, as a potential cause of AUB. Further research is needed to enhance understanding of the epidemiology, risk factors, and clinical manifestations of endometrial aspergillosis. |
| format | Article |
| id | doaj-art-e2a83f2285c443d7b8f77631ac8eca36 |
| institution | OA Journals |
| issn | 2050-0904 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical Case Reports |
| spelling | doaj-art-e2a83f2285c443d7b8f77631ac8eca362025-08-20T02:15:51ZengWileyClinical Case Reports2050-09042025-02-01132n/an/a10.1002/ccr3.70146A Unique Case of Fungal Endometritis Caused by Aspergillus quadrilineatus in an Immunocompetent Woman and Literature ReviewFatemeh Zahra Ranjbar Golafshani0Erfan Ghaffari Lashkenari1Firoozeh Kermani2Soheila Abbaszadeh Godarzi3Saeid Mahdavi Omran4Parasitology and medical mycology Department, Faculty of Medicine Babol University of Medical Sciences Babol IranStudent Research Committee Babol University of Medical Sciences Babol IranParasitology and medical mycology Department, Faculty of Medicine Babol University of Medical Sciences Babol IranObstetrics and Gynecology Department, Faculty of Medicine Babol University of Medical Sciences Babol IranParasitology and medical mycology Department, Faculty of Medicine Babol University of Medical Sciences Babol IranABSTRACT Abnormal uterine bleeding (AUB) is a common gynecological concern often attributed to hormonal disorders, malignancies, or infections. While bacterial and viral infections are frequently investigated, fungal infections, such as aspergillosis, are often overlooked. This case report highlights a rare instance of endometrial aspergillosis caused by Aspergillus quadrilineatus in an immunocompetent woman. A 64‐year‐old woman presented with persistent vaginal bleeding. Histopathological examination of endometrial tissue revealed septate hyphae consistent with fungal infection. Molecular analysis identified the causative agent as A. quadrilineatus. The A. quadrilineatus isolate demonstrated susceptibility to various antifungal agents, including azoles and amphotericin B. This report emphasizes the need for increased awareness of fungal infections, including aspergillosis, as a potential cause of AUB. Further research is needed to enhance understanding of the epidemiology, risk factors, and clinical manifestations of endometrial aspergillosis.https://doi.org/10.1002/ccr3.70146Aspergillus quadrilineatusendometrial aspergillosisendometritismetrorrhagia |
| spellingShingle | Fatemeh Zahra Ranjbar Golafshani Erfan Ghaffari Lashkenari Firoozeh Kermani Soheila Abbaszadeh Godarzi Saeid Mahdavi Omran A Unique Case of Fungal Endometritis Caused by Aspergillus quadrilineatus in an Immunocompetent Woman and Literature Review Clinical Case Reports Aspergillus quadrilineatus endometrial aspergillosis endometritis metrorrhagia |
| title | A Unique Case of Fungal Endometritis Caused by Aspergillus quadrilineatus in an Immunocompetent Woman and Literature Review |
| title_full | A Unique Case of Fungal Endometritis Caused by Aspergillus quadrilineatus in an Immunocompetent Woman and Literature Review |
| title_fullStr | A Unique Case of Fungal Endometritis Caused by Aspergillus quadrilineatus in an Immunocompetent Woman and Literature Review |
| title_full_unstemmed | A Unique Case of Fungal Endometritis Caused by Aspergillus quadrilineatus in an Immunocompetent Woman and Literature Review |
| title_short | A Unique Case of Fungal Endometritis Caused by Aspergillus quadrilineatus in an Immunocompetent Woman and Literature Review |
| title_sort | unique case of fungal endometritis caused by aspergillus quadrilineatus in an immunocompetent woman and literature review |
| topic | Aspergillus quadrilineatus endometrial aspergillosis endometritis metrorrhagia |
| url | https://doi.org/10.1002/ccr3.70146 |
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