Influenza-Associated Disease Burden in Kenya: A Systematic Review of Literature.
<h4>Background</h4>In Kenya data on the burden of influenza disease are needed to inform influenza control policies.<h4>Methods</h4>We conducted a systematic review of published data describing the influenza disease burden in Kenya using surveillance data collected until Dece...
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Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0138708 |
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| author | Gideon O Emukule John Paget Koos van der Velden Joshua A Mott |
| author_facet | Gideon O Emukule John Paget Koos van der Velden Joshua A Mott |
| author_sort | Gideon O Emukule |
| collection | DOAJ |
| description | <h4>Background</h4>In Kenya data on the burden of influenza disease are needed to inform influenza control policies.<h4>Methods</h4>We conducted a systematic review of published data describing the influenza disease burden in Kenya using surveillance data collected until December 2013. We included studies with laboratory confirmation of influenza, well-defined catchment populations, case definitions used to sample patients for testing and a description of the laboratory methods used for influenza testing. Studies with or without any adjustments on the incidence rates were included.<h4>Results</h4>Ten studies reporting the incidence of medically-attended and non-medically attended influenza were reviewed. For all age groups, the influenza positive proportion ranged from 5-10% among hospitalized patients, and 5-27% among all medically-attended patients (a combination of in- and outpatients). The adjusted incidence rate of hospitalizations with influenza among children < 5 years ranged from 2.7-4.7 per 1,000 [5.7 per 1,000 in children < 6 months old], and were 7-10 times higher compared to persons aged ≥ 5 years. The adjusted incidence of all medically-attended influenza among children aged < 5 years ranged from 13.0-58.0 per 1,000 compared to 4.3-26.0 per 1,000 among persons aged ≥ 5 years.<h4>Conclusions</h4>Our review shows an expanding set of literature on disease burden associated with influenza in Kenya, with a substantial burden in children under five years of age. Hospitalizations with influenza in these children were 2-3 times higher than reported in the United States. These findings highlight the possible value of an influenza vaccination program in Kenya, with children < 5 years and pregnant women being potentially important targets. |
| format | Article |
| id | doaj-art-e2a74cf30dd5421fb1fbb96c63a0208a |
| institution | DOAJ |
| issn | 1932-6203 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj-art-e2a74cf30dd5421fb1fbb96c63a0208a2025-08-20T03:17:55ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01109e013870810.1371/journal.pone.0138708Influenza-Associated Disease Burden in Kenya: A Systematic Review of Literature.Gideon O EmukuleJohn PagetKoos van der VeldenJoshua A Mott<h4>Background</h4>In Kenya data on the burden of influenza disease are needed to inform influenza control policies.<h4>Methods</h4>We conducted a systematic review of published data describing the influenza disease burden in Kenya using surveillance data collected until December 2013. We included studies with laboratory confirmation of influenza, well-defined catchment populations, case definitions used to sample patients for testing and a description of the laboratory methods used for influenza testing. Studies with or without any adjustments on the incidence rates were included.<h4>Results</h4>Ten studies reporting the incidence of medically-attended and non-medically attended influenza were reviewed. For all age groups, the influenza positive proportion ranged from 5-10% among hospitalized patients, and 5-27% among all medically-attended patients (a combination of in- and outpatients). The adjusted incidence rate of hospitalizations with influenza among children < 5 years ranged from 2.7-4.7 per 1,000 [5.7 per 1,000 in children < 6 months old], and were 7-10 times higher compared to persons aged ≥ 5 years. The adjusted incidence of all medically-attended influenza among children aged < 5 years ranged from 13.0-58.0 per 1,000 compared to 4.3-26.0 per 1,000 among persons aged ≥ 5 years.<h4>Conclusions</h4>Our review shows an expanding set of literature on disease burden associated with influenza in Kenya, with a substantial burden in children under five years of age. Hospitalizations with influenza in these children were 2-3 times higher than reported in the United States. These findings highlight the possible value of an influenza vaccination program in Kenya, with children < 5 years and pregnant women being potentially important targets.https://doi.org/10.1371/journal.pone.0138708 |
| spellingShingle | Gideon O Emukule John Paget Koos van der Velden Joshua A Mott Influenza-Associated Disease Burden in Kenya: A Systematic Review of Literature. PLoS ONE |
| title | Influenza-Associated Disease Burden in Kenya: A Systematic Review of Literature. |
| title_full | Influenza-Associated Disease Burden in Kenya: A Systematic Review of Literature. |
| title_fullStr | Influenza-Associated Disease Burden in Kenya: A Systematic Review of Literature. |
| title_full_unstemmed | Influenza-Associated Disease Burden in Kenya: A Systematic Review of Literature. |
| title_short | Influenza-Associated Disease Burden in Kenya: A Systematic Review of Literature. |
| title_sort | influenza associated disease burden in kenya a systematic review of literature |
| url | https://doi.org/10.1371/journal.pone.0138708 |
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