Integrated analysis of single-cell and bulk transcriptomics reveals cellular subtypes and molecular features associated with osteosarcoma prognosis

Integrated analysis of single-cell and bulk transcriptomics reveals cellular subtypes and molecular features associated with osteosarcoma prognosis

Abstract Background Osteosarcoma (OS) is the most common primary bone malignancy with variable molecular biology and prognosis. However, our understanding of the association between cell types and OS progression remains poor. Methods We generated a human OS cell atlas by integrating over 110,000 sin...

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Bibliographic Details
Main Authors: Feng Liu, Tingting Zhang, Yongqiang Yang, Kailun Wang, Jinlan Wei, Ji-Hua Shi, Dong Zhang, Xia Sheng, Yi Zhang, Jing Zhou, Faming Zhao
Format: Article
Language:English
Published: BMC 2025-02-01
Series:BMC Cancer
Subjects:
Osteosarcoma
Single-cell RNA-seq
Unfolded protein response
ATF6α
Prognosis
Online Access:https://doi.org/10.1186/s12885-025-13714-y
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