Loss of CDS1 impairs the tumorigenic characteristics of nasopharyngeal carcinoma by modulating lipid metabolism

Loss of CDS1 impairs the tumorigenic characteristics of nasopharyngeal carcinoma by modulating lipid metabolism

The accumulation of lipid droplets (LDs) enhancing nasopharyngeal carcinoma (NPC) cell migration. We reveals that CDP-diacylglycerol synthase 1 (CDS1), an inhibitor of LDs formation, is significantly downregulated in NPC. Restoring CDS1 expression suppresses NPC cell growth, colony formation, tumori...

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Main Authors: Yifang Wang, Limei Li, Liudmila Matskova, Lixian Deng, Danping Li, Yi Huang, Haili Liang, Wen Wang, Ziyuan Liang, Jiaming Su, Weilin Zhao, Tingting Huang, Jiemei Chu, Zhe Zhang, Xue Xiao, Xiaoying Zhou
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Cell Adhesion & Migration
Subjects:
Nasopharyngeal carcinoma
CDP-diacylglycerol synthase 1
lipid droplets
NF-κB signaling pathway
inflammatory cytokines
Online Access:https://www.tandfonline.com/doi/10.1080/19336918.2025.2520629
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https://www.tandfonline.com/doi/10.1080/19336918.2025.2520629

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