Anthocyanins and musculoskeletal diseases: mechanisms and therapeutic potential
BackgroundMusculoskeletal diseases (MSDs) are a common group of conditions involving bones, muscles, cartilage, ligaments, and nerves, which significantly impact patients’ quality of life and ability to participate in society. Anthocyanins (ACNs), as phytochemicals, possess various pharmacological a...
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2025.1602034/full |
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| author | Xing Lv Xiao-peng Zhao Xiao-peng Zhao Wen-cong Li Nai-fei Xing Ke-qiang Zong Ke-qiang Zong Yi Zhai Sheng-lei Yang Ji-yao Zhang Xia Liu Xia Liu Xia Liu |
| author_facet | Xing Lv Xiao-peng Zhao Xiao-peng Zhao Wen-cong Li Nai-fei Xing Ke-qiang Zong Ke-qiang Zong Yi Zhai Sheng-lei Yang Ji-yao Zhang Xia Liu Xia Liu Xia Liu |
| author_sort | Xing Lv |
| collection | DOAJ |
| description | BackgroundMusculoskeletal diseases (MSDs) are a common group of conditions involving bones, muscles, cartilage, ligaments, and nerves, which significantly impact patients’ quality of life and ability to participate in society. Anthocyanins (ACNs), as phytochemicals, possess various pharmacological and biological activities, including anti-apoptotic, antioxidant, anti-inflammatory, and immunosuppressive properties. In recent years, ACNs have shown remarkable potential in improving MSDs. This review article aims to recapitulate the therapeutic potential of ACNs and its mechanism of action in treating MSDs.MethodsExtensive literature was searched and reviewed through online electronic databases (PubMed, Embase, and Web of Science), focusing on analysing the specific roles and molecular mechanisms of ACNs in in vivo and in vitro studies.ResultsACNs exert protective effects on MSDs by targeting multiple key signaling pathways, including mitogen-activated protein kinase (MAPK), nuclear factor-kappaB (NF-κB), Wingless-related integration site (Wnt)/β-catenin, phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt), adenosyl monophosphate-dependent protein kinase (AMPK), receptor activator of nuclear factor-kappaΒ/receptor activator of nuclear factor-kappaB ligand/osteoprotegerin (RANK/RANKL/OPG) and oxidative stress signaling. In addition, ACNs exhibited anti-inflammatory, anti-apoptotic, and immunosuppressive properties. This article reviews the mechanisms and potential therapeutic applications of ACNs in the prevention and alleviation of MSDs, providing valuable reference points for further research and development of ACNs.ConclusionACNs improve the prevention of MSDs through multiple actions such as antioxidant, anti-inflammatory, immunomodulatory and bone metabolism homeostasis regulation. However, results from in vitro and in vivo studies still need to be further validated by human clinical trials. |
| format | Article |
| id | doaj-art-e291c612c75d4865af050e8508abe4bb |
| institution | Kabale University |
| issn | 2296-861X |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj-art-e291c612c75d4865af050e8508abe4bb2025-08-21T04:10:27ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2025-08-011210.3389/fnut.2025.16020341602034Anthocyanins and musculoskeletal diseases: mechanisms and therapeutic potentialXing Lv0Xiao-peng Zhao1Xiao-peng Zhao2Wen-cong Li3Nai-fei Xing4Ke-qiang Zong5Ke-qiang Zong6Yi Zhai7Sheng-lei Yang8Ji-yao Zhang9Xia Liu10Xia Liu11Xia Liu12Department of Rehabilitation, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, ChinaCollege of Pharmacy, Xinjiang Medical University, Ürümqi, ChinaCollege of Exercise and Health, Shenyang Sport University, Shenyang, ChinaDepartment of Neurology, Binzhou Medical University Hospital, Binzhou, ChinaDepartment of Rehabilitation, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, ChinaCollege of Physical Education, Qiqihar University, Qiqihar, ChinaSchool of Sports Medicine and Rehabilitation, Beijing Sport University, Beijing, ChinaShandong Boaoke Biotechnology Co., Ltd., Liaocheng, ChinaSchool of Sports Medicine and Rehabilitation, Beijing Sport University, Beijing, ChinaDepartment of Rehabilitation, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, ChinaDepartment of Rehabilitation, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, ChinaShandong Boaoke Biotechnology Co., Ltd., Liaocheng, ChinaMedical Integration and Practice Center, Shandong University, Jinan, ChinaBackgroundMusculoskeletal diseases (MSDs) are a common group of conditions involving bones, muscles, cartilage, ligaments, and nerves, which significantly impact patients’ quality of life and ability to participate in society. Anthocyanins (ACNs), as phytochemicals, possess various pharmacological and biological activities, including anti-apoptotic, antioxidant, anti-inflammatory, and immunosuppressive properties. In recent years, ACNs have shown remarkable potential in improving MSDs. This review article aims to recapitulate the therapeutic potential of ACNs and its mechanism of action in treating MSDs.MethodsExtensive literature was searched and reviewed through online electronic databases (PubMed, Embase, and Web of Science), focusing on analysing the specific roles and molecular mechanisms of ACNs in in vivo and in vitro studies.ResultsACNs exert protective effects on MSDs by targeting multiple key signaling pathways, including mitogen-activated protein kinase (MAPK), nuclear factor-kappaB (NF-κB), Wingless-related integration site (Wnt)/β-catenin, phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt), adenosyl monophosphate-dependent protein kinase (AMPK), receptor activator of nuclear factor-kappaΒ/receptor activator of nuclear factor-kappaB ligand/osteoprotegerin (RANK/RANKL/OPG) and oxidative stress signaling. In addition, ACNs exhibited anti-inflammatory, anti-apoptotic, and immunosuppressive properties. This article reviews the mechanisms and potential therapeutic applications of ACNs in the prevention and alleviation of MSDs, providing valuable reference points for further research and development of ACNs.ConclusionACNs improve the prevention of MSDs through multiple actions such as antioxidant, anti-inflammatory, immunomodulatory and bone metabolism homeostasis regulation. However, results from in vitro and in vivo studies still need to be further validated by human clinical trials.https://www.frontiersin.org/articles/10.3389/fnut.2025.1602034/fullanthocyaninsosteoporosisrheumatoid arthritisosteoarthritisosteosarcomainflammatory |
| spellingShingle | Xing Lv Xiao-peng Zhao Xiao-peng Zhao Wen-cong Li Nai-fei Xing Ke-qiang Zong Ke-qiang Zong Yi Zhai Sheng-lei Yang Ji-yao Zhang Xia Liu Xia Liu Xia Liu Anthocyanins and musculoskeletal diseases: mechanisms and therapeutic potential Frontiers in Nutrition anthocyanins osteoporosis rheumatoid arthritis osteoarthritis osteosarcoma inflammatory |
| title | Anthocyanins and musculoskeletal diseases: mechanisms and therapeutic potential |
| title_full | Anthocyanins and musculoskeletal diseases: mechanisms and therapeutic potential |
| title_fullStr | Anthocyanins and musculoskeletal diseases: mechanisms and therapeutic potential |
| title_full_unstemmed | Anthocyanins and musculoskeletal diseases: mechanisms and therapeutic potential |
| title_short | Anthocyanins and musculoskeletal diseases: mechanisms and therapeutic potential |
| title_sort | anthocyanins and musculoskeletal diseases mechanisms and therapeutic potential |
| topic | anthocyanins osteoporosis rheumatoid arthritis osteoarthritis osteosarcoma inflammatory |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2025.1602034/full |
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