mGem: The complexity of viral entry—one virus, many receptors
ABSTRACT Binding to cellular receptors initiates viral replication and dictates sites in the host infected by the virus. As illustrated by mammalian orthoreovirus (reovirus), viruses can bind several types of receptors using distinct capsid components to facilitate the viral entry steps of attachmen...
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| Format: | Article |
| Language: | English |
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American Society for Microbiology
2025-03-01
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| Series: | mBio |
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| Online Access: | https://journals.asm.org/doi/10.1128/mbio.02964-24 |
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| author | Terence S. Dermody Danica M. Sutherland |
| author_facet | Terence S. Dermody Danica M. Sutherland |
| author_sort | Terence S. Dermody |
| collection | DOAJ |
| description | ABSTRACT Binding to cellular receptors initiates viral replication and dictates sites in the host infected by the virus. As illustrated by mammalian orthoreovirus (reovirus), viruses can bind several types of receptors using distinct capsid components to facilitate the viral entry steps of attachment, internalization, and disassembly. The outer of the two concentric capsids of reovirus virions is formed by four viral proteins, three of which bind receptors. These capsid–receptor interactions mediate stepwise entry of reovirus, dictate viral tropism in infected animals, and expand the viral host range. Engagement of independent receptors by different capsid proteins is a property of many pathogenic viruses and illustrates common themes of receptor use in viral entry and disease. |
| format | Article |
| id | doaj-art-e2904cdd7ca34186a42685f47999d772 |
| institution | DOAJ |
| issn | 2150-7511 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | American Society for Microbiology |
| record_format | Article |
| series | mBio |
| spelling | doaj-art-e2904cdd7ca34186a42685f47999d7722025-08-20T02:52:41ZengAmerican Society for MicrobiologymBio2150-75112025-03-0116310.1128/mbio.02964-24mGem: The complexity of viral entry—one virus, many receptorsTerence S. Dermody0Danica M. Sutherland1Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USADepartment of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USAABSTRACT Binding to cellular receptors initiates viral replication and dictates sites in the host infected by the virus. As illustrated by mammalian orthoreovirus (reovirus), viruses can bind several types of receptors using distinct capsid components to facilitate the viral entry steps of attachment, internalization, and disassembly. The outer of the two concentric capsids of reovirus virions is formed by four viral proteins, three of which bind receptors. These capsid–receptor interactions mediate stepwise entry of reovirus, dictate viral tropism in infected animals, and expand the viral host range. Engagement of independent receptors by different capsid proteins is a property of many pathogenic viruses and illustrates common themes of receptor use in viral entry and disease.https://journals.asm.org/doi/10.1128/mbio.02964-24virusreceptorsneurotropismviral pathogenesis |
| spellingShingle | Terence S. Dermody Danica M. Sutherland mGem: The complexity of viral entry—one virus, many receptors mBio virus receptors neurotropism viral pathogenesis |
| title | mGem: The complexity of viral entry—one virus, many receptors |
| title_full | mGem: The complexity of viral entry—one virus, many receptors |
| title_fullStr | mGem: The complexity of viral entry—one virus, many receptors |
| title_full_unstemmed | mGem: The complexity of viral entry—one virus, many receptors |
| title_short | mGem: The complexity of viral entry—one virus, many receptors |
| title_sort | mgem the complexity of viral entry one virus many receptors |
| topic | virus receptors neurotropism viral pathogenesis |
| url | https://journals.asm.org/doi/10.1128/mbio.02964-24 |
| work_keys_str_mv | AT terencesdermody mgemthecomplexityofviralentryonevirusmanyreceptors AT danicamsutherland mgemthecomplexityofviralentryonevirusmanyreceptors |