Effects of high-intensity interval training on physical performance, systolic blood pressure, oxidative stress and inflammatory markers in skeletal muscle of spontaneously hypertensive rats.
<h4>Aim</h4>To investigate whether high-intensity interval training (HIIT) improves physical performance, systolic blood pressure, and markers of oxidative stress and inflammation in skeletal muscle of spontaneously hypertensive rats (SHR).<h4>Methods</h4>Nineteen male SHR ra...
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Public Library of Science (PLoS)
2025-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0316441 |
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| author | Thaynara Zanoni D'Almeida Mariana Janini Gomes Leticia Estevam Engel Ines Cristina Giometti Natalia Zamberlan Ferreira Rafael Stuani Camila Renata Corrêa Robson Chacon Castoldi Sarah Gomes Nunes Andreo Fernando Aguiar Anthony César Castilho Marina Politi Okoshi Francis Lopes Pacagnelli |
| author_facet | Thaynara Zanoni D'Almeida Mariana Janini Gomes Leticia Estevam Engel Ines Cristina Giometti Natalia Zamberlan Ferreira Rafael Stuani Camila Renata Corrêa Robson Chacon Castoldi Sarah Gomes Nunes Andreo Fernando Aguiar Anthony César Castilho Marina Politi Okoshi Francis Lopes Pacagnelli |
| author_sort | Thaynara Zanoni D'Almeida |
| collection | DOAJ |
| description | <h4>Aim</h4>To investigate whether high-intensity interval training (HIIT) improves physical performance, systolic blood pressure, and markers of oxidative stress and inflammation in skeletal muscle of spontaneously hypertensive rats (SHR).<h4>Methods</h4>Nineteen male SHR rats were randomly assigned to two groups: sedentary (SHRC) and trained (SHR+T). The SHR+T group trained five times a week for eight weeks on a treadmill, while the SHR group remained without any exercise stimulus throughout the experimental period. Maximum physical performance and systolic blood pressure (SBP) were assessed before and after the training period. The following variables were measured in the tibialis anterior (TA) muscle: gene expression of the NADPH oxidase complex (NOX2, NOX4, p22phox, p47phox) and the NF-kB pathway (NF-kB and Ik-B), lipid peroxidation (malonaldehyde; MDA), protein carbonylation, hydrophilic antioxidant capacity (HAC) and pro-inflammatory cytokines (IL-6 and TNF-α).<h4>Results</h4>SHR+T rats showed higher physical performance and levels of IL-6, and lower SBP and protein carbonylation (p<0.05), compared with SHRC rats. No significant differences (p>0.05) were observed in the other variables.<h4>Significance</h4>Our results indicate that HIIT is an effective non-pharmacologic strategy to improve physical performance, reduce SBP, and modulate the skeletal muscle oxidative damage and inflammation in hypertensive rats. |
| format | Article |
| id | doaj-art-e28b0d7575b24c438e33acc8709f6a5d |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-e28b0d7575b24c438e33acc8709f6a5d2025-02-09T05:30:37ZengPublic Library of Science (PLoS)PLoS ONE1932-62032025-01-01202e031644110.1371/journal.pone.0316441Effects of high-intensity interval training on physical performance, systolic blood pressure, oxidative stress and inflammatory markers in skeletal muscle of spontaneously hypertensive rats.Thaynara Zanoni D'AlmeidaMariana Janini GomesLeticia Estevam EngelInes Cristina GiomettiNatalia Zamberlan FerreiraRafael StuaniCamila Renata CorrêaRobson Chacon CastoldiSarah Gomes NunesAndreo Fernando AguiarAnthony César CastilhoMarina Politi OkoshiFrancis Lopes Pacagnelli<h4>Aim</h4>To investigate whether high-intensity interval training (HIIT) improves physical performance, systolic blood pressure, and markers of oxidative stress and inflammation in skeletal muscle of spontaneously hypertensive rats (SHR).<h4>Methods</h4>Nineteen male SHR rats were randomly assigned to two groups: sedentary (SHRC) and trained (SHR+T). The SHR+T group trained five times a week for eight weeks on a treadmill, while the SHR group remained without any exercise stimulus throughout the experimental period. Maximum physical performance and systolic blood pressure (SBP) were assessed before and after the training period. The following variables were measured in the tibialis anterior (TA) muscle: gene expression of the NADPH oxidase complex (NOX2, NOX4, p22phox, p47phox) and the NF-kB pathway (NF-kB and Ik-B), lipid peroxidation (malonaldehyde; MDA), protein carbonylation, hydrophilic antioxidant capacity (HAC) and pro-inflammatory cytokines (IL-6 and TNF-α).<h4>Results</h4>SHR+T rats showed higher physical performance and levels of IL-6, and lower SBP and protein carbonylation (p<0.05), compared with SHRC rats. No significant differences (p>0.05) were observed in the other variables.<h4>Significance</h4>Our results indicate that HIIT is an effective non-pharmacologic strategy to improve physical performance, reduce SBP, and modulate the skeletal muscle oxidative damage and inflammation in hypertensive rats.https://doi.org/10.1371/journal.pone.0316441 |
| spellingShingle | Thaynara Zanoni D'Almeida Mariana Janini Gomes Leticia Estevam Engel Ines Cristina Giometti Natalia Zamberlan Ferreira Rafael Stuani Camila Renata Corrêa Robson Chacon Castoldi Sarah Gomes Nunes Andreo Fernando Aguiar Anthony César Castilho Marina Politi Okoshi Francis Lopes Pacagnelli Effects of high-intensity interval training on physical performance, systolic blood pressure, oxidative stress and inflammatory markers in skeletal muscle of spontaneously hypertensive rats. PLoS ONE |
| title | Effects of high-intensity interval training on physical performance, systolic blood pressure, oxidative stress and inflammatory markers in skeletal muscle of spontaneously hypertensive rats. |
| title_full | Effects of high-intensity interval training on physical performance, systolic blood pressure, oxidative stress and inflammatory markers in skeletal muscle of spontaneously hypertensive rats. |
| title_fullStr | Effects of high-intensity interval training on physical performance, systolic blood pressure, oxidative stress and inflammatory markers in skeletal muscle of spontaneously hypertensive rats. |
| title_full_unstemmed | Effects of high-intensity interval training on physical performance, systolic blood pressure, oxidative stress and inflammatory markers in skeletal muscle of spontaneously hypertensive rats. |
| title_short | Effects of high-intensity interval training on physical performance, systolic blood pressure, oxidative stress and inflammatory markers in skeletal muscle of spontaneously hypertensive rats. |
| title_sort | effects of high intensity interval training on physical performance systolic blood pressure oxidative stress and inflammatory markers in skeletal muscle of spontaneously hypertensive rats |
| url | https://doi.org/10.1371/journal.pone.0316441 |
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