Drug resistance patterns of Mycobacterium tuberculosis complex and risk factors associated with multidrug-resistant tuberculosis in the upper southern part of Thailand
Background: this study aimed to assess the drug resistant pattern of Mycobacterium tuberculosis complex (MTBC) and the risk factors associated to multidrug-resistant tuberculosis cases (MDR-TB) in upper part of southern Thailand. Methods: a total of 3238 TB cases was retrieved from a database of th...
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| Format: | Article |
| Language: | English |
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Milano University Press
2019-09-01
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| Series: | Epidemiology, Biostatistics and Public Health |
| Online Access: | https://ebph.it/article/view/13124 |
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| author | Tum Boonrod Lily Ingsrisawang Petchawan Pungrassami Supattra Sengsong Arisa Bromnavej Pinkamon Waseewiwat Natthapakam Sreevijit Bunrit Bunsanong Chusri Bunsin |
| author_facet | Tum Boonrod Lily Ingsrisawang Petchawan Pungrassami Supattra Sengsong Arisa Bromnavej Pinkamon Waseewiwat Natthapakam Sreevijit Bunrit Bunsanong Chusri Bunsin |
| author_sort | Tum Boonrod |
| collection | DOAJ |
| description | Background: this study aimed to assess the drug resistant pattern of Mycobacterium tuberculosis complex (MTBC) and the risk factors associated to multidrug-resistant tuberculosis cases (MDR-TB) in upper part of southern Thailand.
Methods: a total of 3238 TB cases was retrieved from a database of the office of prevention and control disease region 11. Only 1008 cases were confirmed by culture growth for Mycobacterium tuberculosis and drug-susceptibility testing (DST) during a period of 4 years (January 2013 to December 2016). The risk factors, including gender, age group, residence place, and history of treatment were analysed using multivariate logistic regression to predict the MDR-TB cases.
Results: among 1008 TB cases included in study, 77.4% of them were males, 31.5% lived in rural area with median age of 45.0 years (IQR = 23.0), 27.6% were retreatment for tuberculosis, 25.9%, 10.8%, 3.0%, 10.7% and 9.1 were determined to be resistant to isoniazid, rifampicin, ethambutol, streptomycin and MDR-TB, respectively. Adjusted odds ratios (95% confidence interval) of MDR-TB were 5.4 (2.68-11.03), and 4.2 (2.10, 8.45) for retreatment patients, and on treatment patients, respectively.
Conclusions: drug resistance tuberculosis is considerable problem in upper part of southern Thailand. Major risk factors involved previous history of TB treatment. Thus, it emphasizes on patients who had a history of previous TB treatment. |
| format | Article |
| id | doaj-art-e285b43012314768be2f305a01c46764 |
| institution | DOAJ |
| issn | 2282-0930 |
| language | English |
| publishDate | 2019-09-01 |
| publisher | Milano University Press |
| record_format | Article |
| series | Epidemiology, Biostatistics and Public Health |
| spelling | doaj-art-e285b43012314768be2f305a01c467642025-08-20T03:06:14ZengMilano University PressEpidemiology, Biostatistics and Public Health2282-09302019-09-0116310.2427/1312411214Drug resistance patterns of Mycobacterium tuberculosis complex and risk factors associated with multidrug-resistant tuberculosis in the upper southern part of ThailandTum Boonrod0Lily Ingsrisawang1Petchawan Pungrassami2Supattra Sengsong3Arisa Bromnavej4Pinkamon Waseewiwat5Natthapakam Sreevijit6Bunrit Bunsanong7Chusri Bunsin8Department of Statistics, Faculty of Science, Kasetsart University, Bangkok, ThailandDepartment of Statistics, Faculty of Science, Kasetsart University, Bangkok, ThailandBureau of Tuberculosis, Department of Disease Control, Ministry of Public Health, ThailandThe office of prevention and control disease region 11, ThailandThe office of prevention and control disease region 11, ThailandThe office of prevention and control disease region 11, ThailandThe office of prevention and control disease region 11, ThailandThe office of prevention and control disease region 11, ThailandThe office of prevention and control disease region 11, ThailandBackground: this study aimed to assess the drug resistant pattern of Mycobacterium tuberculosis complex (MTBC) and the risk factors associated to multidrug-resistant tuberculosis cases (MDR-TB) in upper part of southern Thailand. Methods: a total of 3238 TB cases was retrieved from a database of the office of prevention and control disease region 11. Only 1008 cases were confirmed by culture growth for Mycobacterium tuberculosis and drug-susceptibility testing (DST) during a period of 4 years (January 2013 to December 2016). The risk factors, including gender, age group, residence place, and history of treatment were analysed using multivariate logistic regression to predict the MDR-TB cases. Results: among 1008 TB cases included in study, 77.4% of them were males, 31.5% lived in rural area with median age of 45.0 years (IQR = 23.0), 27.6% were retreatment for tuberculosis, 25.9%, 10.8%, 3.0%, 10.7% and 9.1 were determined to be resistant to isoniazid, rifampicin, ethambutol, streptomycin and MDR-TB, respectively. Adjusted odds ratios (95% confidence interval) of MDR-TB were 5.4 (2.68-11.03), and 4.2 (2.10, 8.45) for retreatment patients, and on treatment patients, respectively. Conclusions: drug resistance tuberculosis is considerable problem in upper part of southern Thailand. Major risk factors involved previous history of TB treatment. Thus, it emphasizes on patients who had a history of previous TB treatment.https://ebph.it/article/view/13124 |
| spellingShingle | Tum Boonrod Lily Ingsrisawang Petchawan Pungrassami Supattra Sengsong Arisa Bromnavej Pinkamon Waseewiwat Natthapakam Sreevijit Bunrit Bunsanong Chusri Bunsin Drug resistance patterns of Mycobacterium tuberculosis complex and risk factors associated with multidrug-resistant tuberculosis in the upper southern part of Thailand Epidemiology, Biostatistics and Public Health |
| title | Drug resistance patterns of Mycobacterium tuberculosis complex and risk factors associated with multidrug-resistant tuberculosis in the upper southern part of Thailand |
| title_full | Drug resistance patterns of Mycobacterium tuberculosis complex and risk factors associated with multidrug-resistant tuberculosis in the upper southern part of Thailand |
| title_fullStr | Drug resistance patterns of Mycobacterium tuberculosis complex and risk factors associated with multidrug-resistant tuberculosis in the upper southern part of Thailand |
| title_full_unstemmed | Drug resistance patterns of Mycobacterium tuberculosis complex and risk factors associated with multidrug-resistant tuberculosis in the upper southern part of Thailand |
| title_short | Drug resistance patterns of Mycobacterium tuberculosis complex and risk factors associated with multidrug-resistant tuberculosis in the upper southern part of Thailand |
| title_sort | drug resistance patterns of mycobacterium tuberculosis complex and risk factors associated with multidrug resistant tuberculosis in the upper southern part of thailand |
| url | https://ebph.it/article/view/13124 |
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