Regenerative Therapy in Erectile Dysfunction: A Survey on Current Global Practice Trends and GAF Expert Recommendations
Purpose: This study aimed to examine current global practices in regenerative therapy (RT) for erectile dysfunction (ED) and to establish expert recommendations for its use, addressing the current lack of solid evidence and standardized guidelines. Materials and Methods: A 39-question survey was d...
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| Format: | Article |
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Korean Society for Sexual Medicine and Andrology
2025-04-01
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| Series: | The World Journal of Men's Health |
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| author | Manaf Al Hashimi Germar-M Pinggera Taymour Mostafa Amarnath Rambhatla Taha Hamoda Rupin Shah Eric Chung Ahmed Harraz Mohamed Arafa Tuncay Toprak Omer Raheem Carlo Giulioni Ponco Birowo Luca Boeri Yassir Jassim Priyank Kothari Ranjit Vishwakarma Bahadir Sahin Widi Atmoko Safar Gamidov Cesar Rojas-Cruz Darren Katz Adriano Fregonesi Nazim Gherabi Armand Zini Christopher Chee Kong Ho Mohamed S. Al-Marhoon Marlon Martinez Giorgio Ivan Russo Ayman Rashed Gian Maria Busetto Edmund Ko Hyun Jun Park Selahittin Cayan Ramadan Saleh Osvaldo Rajmil Dong Suk Kim Giovanni Colpi Ryan Smith Maged Ragab Ates Kadioglu Quang Nguyen Kadir Bocu Ahmed El-Sakka Charalampos Thomas Hussain M Alnajjar Hiva Alipour Ashok Agarwal |
| author_facet | Manaf Al Hashimi Germar-M Pinggera Taymour Mostafa Amarnath Rambhatla Taha Hamoda Rupin Shah Eric Chung Ahmed Harraz Mohamed Arafa Tuncay Toprak Omer Raheem Carlo Giulioni Ponco Birowo Luca Boeri Yassir Jassim Priyank Kothari Ranjit Vishwakarma Bahadir Sahin Widi Atmoko Safar Gamidov Cesar Rojas-Cruz Darren Katz Adriano Fregonesi Nazim Gherabi Armand Zini Christopher Chee Kong Ho Mohamed S. Al-Marhoon Marlon Martinez Giorgio Ivan Russo Ayman Rashed Gian Maria Busetto Edmund Ko Hyun Jun Park Selahittin Cayan Ramadan Saleh Osvaldo Rajmil Dong Suk Kim Giovanni Colpi Ryan Smith Maged Ragab Ates Kadioglu Quang Nguyen Kadir Bocu Ahmed El-Sakka Charalampos Thomas Hussain M Alnajjar Hiva Alipour Ashok Agarwal |
| author_sort | Manaf Al Hashimi |
| collection | DOAJ |
| description | Purpose: This study aimed to examine current global practices in regenerative therapy (RT) for erectile dysfunction (ED) and
to establish expert recommendations for its use, addressing the current lack of solid evidence and standardized guidelines.
Materials and Methods: A 39-question survey was developed by senior Global Andrology Forum (GAF) experts to comprehensively
cover clinical aspects of RT. This was distributed globally via a secure online Google Form to ED specialists through
the GAF website, international professional societies, and social media, the responses were analyzed and presented for frequencies
as percentages. Consensus on expert recommendations for RT use was achieved using the Delphi method.
Results: Out of 479 respondents from 62 countries, a third reported using RT for ED. The most popular treatment was low-intensity
shock wave therapy (54.6%), followed by platelet-rich plasma (24.5%) and their combination (14.7%), with stem cell
therapy being the least used (3.7%). The primary indication for RT was the refractory or adverse effects of PDE5 inhibitors,
with the best effectiveness reported in middle-aged and mild-to-moderate ED patients. Respondents were confident about its
overall safety, with a significant number expressing interest in RT’s future use, despite pending guidelines support.
Conclusions: This inaugural global survey reveals a growing use of RT in ED treatment, showcasing its diverse clinical applications
and potential for future widespread adoption. However, the lack of comprehensive evidence and clear guidelines
requires further research to standardize RT practices in ED treatment. |
| format | Article |
| id | doaj-art-e284f56f895240128fcc2a409b22d96d |
| institution | Kabale University |
| issn | 2287-4208 2287-4690 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Korean Society for Sexual Medicine and Andrology |
| record_format | Article |
| series | The World Journal of Men's Health |
| spelling | doaj-art-e284f56f895240128fcc2a409b22d96d2025-08-20T03:40:51ZengKorean Society for Sexual Medicine and AndrologyThe World Journal of Men's Health2287-42082287-46902025-04-0143235937510.5534/wjmh.240086Regenerative Therapy in Erectile Dysfunction: A Survey on Current Global Practice Trends and GAF Expert RecommendationsManaf Al Hashimi0https://orcid.org/0000-0002-2458-179XGermar-M Pinggera1https://orcid.org/0000-0001-6463-2494Taymour Mostafa2https://orcid.org/0000-0003-3627-0662Amarnath Rambhatla3https://orcid.org/0000-0002-1383-6670Taha Hamoda4https://orcid.org/0000-0002-8070-4088Rupin Shah5https://orcid.org/0000-0002-7868-5949Eric Chung6https://orcid.org/0000-0003-3373-3668Ahmed Harraz7https://orcid.org/0000-0002-8902-517XMohamed Arafa8https://orcid.org/0000-0003-0107-8857Tuncay Toprak9https://orcid.org/0000-0003-1348-5273Omer Raheem10https://orcid.org/0000-0001-6117-116XCarlo Giulioni11https://orcid.org/0000-0001-9934-4011Ponco Birowo12https://orcid.org/0000-0003-2934-6753Luca Boeri13https://orcid.org/0000-0003-0040-784XYassir Jassim14https://orcid.org/0000-0001-8948-1338Priyank Kothari15https://orcid.org/0000-0002-3940-952XRanjit Vishwakarma16https://orcid.org/0000-0002-6784-2830Bahadir Sahin17https://orcid.org/0000-0002-4874-4178Widi Atmoko18https://orcid.org/0000-0002-7793-7083Safar Gamidov19https://orcid.org/0000-0002-9128-2714Cesar Rojas-Cruz20https://orcid.org/0000-0002-3978-491XDarren Katz21https://orcid.org/0000-0003-0861-5643Adriano Fregonesi22https://orcid.org/0000-0002-6853-1014Nazim Gherabi23https://orcid.org/0000-0001-7364-047XArmand Zini24https://orcid.org/0000-0002-2194-5578Christopher Chee Kong Ho25https://orcid.org/0000-0002-8757-6867Mohamed S. Al-Marhoon26https://orcid.org/0000-0002-8397-1560Marlon Martinez27https://orcid.org/0000-0002-1191-8154Giorgio Ivan Russo28https://orcid.org/0000-0003-4687-7353Ayman Rashed29https://orcid.org/0000-0003-1994-2228Gian Maria Busetto30https://orcid.org/0000-0002-7291-0316Edmund Ko31https://orcid.org/0000-0002-7465-3616Hyun Jun Park32https://orcid.org/0000-0003-0566-9574Selahittin Cayan33https://orcid.org/0000-0003-4784-2208Ramadan Saleh34https://orcid.org/0000-0003-0503-3533Osvaldo Rajmil35https://orcid.org/0000-0003-1987-9206Dong Suk Kim36https://orcid.org/0000-0001-7350-0303Giovanni Colpi37https://orcid.org/0000-0003-1431-1777Ryan Smith38https://orcid.org/0000-0002-3880-9740Maged Ragab39https://orcid.org/0000-0003-4790-3322Ates Kadioglu40https://orcid.org/0000-0002-4239-7638Quang Nguyen41https://orcid.org/0000-0002-1670-8885Kadir Bocu42https://orcid.org/0000-0003-4323-4037Ahmed El-Sakka43https://orcid.org/0000-0001-8671-5952Charalampos Thomas44https://orcid.org/0000-0003-0139-2221Hussain M Alnajjar45https://orcid.org/0000-0001-6364-0310Hiva Alipour46https://orcid.org/0000-0002-8500-4208Ashok Agarwal47https://orcid.org/0000-0003-0585-1026Department of Urology, Burjeel Hospital, Abu Dhabi, UAEGlobal Andrology Forum, Moreland Hills, OH, USAGlobal Andrology Forum, Moreland Hills, OH, USAGlobal Andrology Forum, Moreland Hills, OH, USAGlobal Andrology Forum, Moreland Hills, OH, USAGlobal Andrology Forum, Moreland Hills, OH, USAGlobal Andrology Forum, Moreland Hills, OH, USAGlobal Andrology Forum, Moreland Hills, OH, USAGlobal Andrology Forum, Moreland Hills, OH, USAGlobal Andrology Forum, Moreland Hills, OH, USAGlobal Andrology Forum, Moreland Hills, OH, USAGlobal Andrology Forum, Moreland Hills, OH, USAGlobal Andrology Forum, Moreland Hills, OH, USAGlobal Andrology Forum, Moreland Hills, OH, USAGlobal Andrology Forum, Moreland Hills, OH, USAGlobal Andrology Forum, Moreland Hills, OH, USAGlobal Andrology Forum, Moreland Hills, OH, USAGlobal Andrology Forum, Moreland Hills, OH, USAGlobal Andrology Forum, Moreland Hills, OH, USAGlobal Andrology Forum, Moreland Hills, OH, USAGlobal Andrology Forum, Moreland Hills, OH, USAGlobal Andrology Forum, Moreland Hills, OH, USAGlobal Andrology Forum, Moreland Hills, OH, USAGlobal Andrology Forum, Moreland Hills, OH, USAGlobal Andrology Forum, Moreland Hills, OH, USAGlobal Andrology Forum, Moreland Hills, OH, USAGlobal Andrology Forum, Moreland Hills, OH, USAGlobal Andrology Forum, Moreland Hills, OH, USAGlobal Andrology Forum, Moreland Hills, OH, USAGlobal Andrology Forum, Moreland Hills, OH, USAGlobal Andrology Forum, Moreland Hills, OH, USAGlobal Andrology Forum, Moreland Hills, OH, USAGlobal Andrology Forum, Moreland Hills, OH, USAGlobal Andrology Forum, Moreland Hills, OH, USAGlobal Andrology Forum, Moreland Hills, OH, USAGlobal Andrology Forum, Moreland Hills, OH, USAGlobal Andrology Forum, Moreland Hills, OH, USAGlobal Andrology Forum, Moreland Hills, OH, USAGlobal Andrology Forum, Moreland Hills, OH, USAGlobal Andrology Forum, Moreland Hills, OH, USAGlobal Andrology Forum, Moreland Hills, OH, USAGlobal Andrology Forum, Moreland Hills, OH, USAGlobal Andrology Forum, Moreland Hills, OH, USAGlobal Andrology Forum, Moreland Hills, OH, USAGlobal Andrology Forum, Moreland Hills, OH, USAGlobal Andrology Forum, Moreland Hills, OH, USAGlobal Andrology Forum, Moreland Hills, OH, USAGlobal Andrology Forum, Moreland Hills, OH, USAPurpose: This study aimed to examine current global practices in regenerative therapy (RT) for erectile dysfunction (ED) and to establish expert recommendations for its use, addressing the current lack of solid evidence and standardized guidelines. Materials and Methods: A 39-question survey was developed by senior Global Andrology Forum (GAF) experts to comprehensively cover clinical aspects of RT. This was distributed globally via a secure online Google Form to ED specialists through the GAF website, international professional societies, and social media, the responses were analyzed and presented for frequencies as percentages. Consensus on expert recommendations for RT use was achieved using the Delphi method. Results: Out of 479 respondents from 62 countries, a third reported using RT for ED. The most popular treatment was low-intensity shock wave therapy (54.6%), followed by platelet-rich plasma (24.5%) and their combination (14.7%), with stem cell therapy being the least used (3.7%). The primary indication for RT was the refractory or adverse effects of PDE5 inhibitors, with the best effectiveness reported in middle-aged and mild-to-moderate ED patients. Respondents were confident about its overall safety, with a significant number expressing interest in RT’s future use, despite pending guidelines support. Conclusions: This inaugural global survey reveals a growing use of RT in ED treatment, showcasing its diverse clinical applications and potential for future widespread adoption. However, the lack of comprehensive evidence and clear guidelines requires further research to standardize RT practices in ED treatment.erectile dysfunctionextracorporeal shockwave therapyplatelet-rich plasmaregenerative medicinestem cellssurveys and questionnaires |
| spellingShingle | Manaf Al Hashimi Germar-M Pinggera Taymour Mostafa Amarnath Rambhatla Taha Hamoda Rupin Shah Eric Chung Ahmed Harraz Mohamed Arafa Tuncay Toprak Omer Raheem Carlo Giulioni Ponco Birowo Luca Boeri Yassir Jassim Priyank Kothari Ranjit Vishwakarma Bahadir Sahin Widi Atmoko Safar Gamidov Cesar Rojas-Cruz Darren Katz Adriano Fregonesi Nazim Gherabi Armand Zini Christopher Chee Kong Ho Mohamed S. Al-Marhoon Marlon Martinez Giorgio Ivan Russo Ayman Rashed Gian Maria Busetto Edmund Ko Hyun Jun Park Selahittin Cayan Ramadan Saleh Osvaldo Rajmil Dong Suk Kim Giovanni Colpi Ryan Smith Maged Ragab Ates Kadioglu Quang Nguyen Kadir Bocu Ahmed El-Sakka Charalampos Thomas Hussain M Alnajjar Hiva Alipour Ashok Agarwal Regenerative Therapy in Erectile Dysfunction: A Survey on Current Global Practice Trends and GAF Expert Recommendations The World Journal of Men's Health erectile dysfunction extracorporeal shockwave therapy platelet-rich plasma regenerative medicine stem cells surveys and questionnaires |
| title | Regenerative Therapy in Erectile Dysfunction: A Survey on Current Global Practice Trends and GAF Expert Recommendations |
| title_full | Regenerative Therapy in Erectile Dysfunction: A Survey on Current Global Practice Trends and GAF Expert Recommendations |
| title_fullStr | Regenerative Therapy in Erectile Dysfunction: A Survey on Current Global Practice Trends and GAF Expert Recommendations |
| title_full_unstemmed | Regenerative Therapy in Erectile Dysfunction: A Survey on Current Global Practice Trends and GAF Expert Recommendations |
| title_short | Regenerative Therapy in Erectile Dysfunction: A Survey on Current Global Practice Trends and GAF Expert Recommendations |
| title_sort | regenerative therapy in erectile dysfunction a survey on current global practice trends and gaf expert recommendations |
| topic | erectile dysfunction extracorporeal shockwave therapy platelet-rich plasma regenerative medicine stem cells surveys and questionnaires |
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