Diffuse-Type Tenosynovial Giant Cell Tumor of the Knee: Clinical Course After Anterior Open Synovectomy
Diffuse type tenosynovial giant cell tumor (D-TGCT) of the knee presents with stiffness, pain and swelling with surgery being the mainstay treatment. However, the literature lacks data on clinical course of range of motion, pain (ROM), and swelling after open synovectomy for D-TGCT. Therefore, this...
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MDPI AG
2025-06-01
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| Series: | Current Oncology |
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| Online Access: | https://www.mdpi.com/1718-7729/32/6/342 |
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| author | Alessandro Bruschi Eric Staals Andrea Sambri Luca Cevolani Marco Gambarotti Alberto Righi Michele Fiore Eleonora Villari Stefano Pasini Maria Giulia Pirini Massimiliano De Paolis Davide Maria Donati |
| author_facet | Alessandro Bruschi Eric Staals Andrea Sambri Luca Cevolani Marco Gambarotti Alberto Righi Michele Fiore Eleonora Villari Stefano Pasini Maria Giulia Pirini Massimiliano De Paolis Davide Maria Donati |
| author_sort | Alessandro Bruschi |
| collection | DOAJ |
| description | Diffuse type tenosynovial giant cell tumor (D-TGCT) of the knee presents with stiffness, pain and swelling with surgery being the mainstay treatment. However, the literature lacks data on clinical course of range of motion, pain (ROM), and swelling after open synovectomy for D-TGCT. Therefore, this study aims to evaluate clinical course after open anterior synovectomy. A retrospective analysis was conducted on 214 patients treated for TGCT at our Institutions between 2010 and 2023. 51 patients with anterior knee D-TGCT who underwent open anterior synovectomy were included. Pre- and postoperative assessments included ROM, pain (VAS scale), and reported swelling. The mean knee flexion increased from 100° (SD 14.28) preoperatively to 131.8° (12.64) at 12 months post-surgery. Knee extension remained stable, ranging from 178.4° preoperatively to 179.2° at the final follow-up. Pain decreased from a mean of 5.0 (SD 2.8) preoperatively to 0.5 (SD 0.7) at 12 months. Swelling was initially reported in 90.4% of patients, with 95.74% of them showing improvement at six months, and 100% at 12 months. Open anterior synovectomy effectively improves knee function, pain, swelling in patients with anterior knee D-TGCT, although functional recovery may take up to 6–12 months. |
| format | Article |
| id | doaj-art-e2849ac449ac4a1ebd5f0f9fa98b64b8 |
| institution | OA Journals |
| issn | 1198-0052 1718-7729 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj-art-e2849ac449ac4a1ebd5f0f9fa98b64b82025-08-20T02:24:25ZengMDPI AGCurrent Oncology1198-00521718-77292025-06-0132634210.3390/curroncol32060342Diffuse-Type Tenosynovial Giant Cell Tumor of the Knee: Clinical Course After Anterior Open SynovectomyAlessandro Bruschi0Eric Staals1Andrea Sambri2Luca Cevolani3Marco Gambarotti4Alberto Righi5Michele Fiore6Eleonora Villari7Stefano Pasini8Maria Giulia Pirini9Massimiliano De Paolis10Davide Maria Donati11Orthopedic and Traumatology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, ItalyOrthopaedic Oncology Unit, IRCCS Istituto Ortopedico Rizzoli, Via Pupilli 1, 40136 Bologna, ItalyOrthopedic and Traumatology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, ItalyOrthopaedic Oncology Unit, IRCCS Istituto Ortopedico Rizzoli, Via Pupilli 1, 40136 Bologna, ItalyDepartment of Pathology, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, ItalyDepartment of Pathology, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, ItalyOrthopedic and Traumatology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, ItalyOrthopedic and Traumatology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, ItalySpine Surgery Unit, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, ItalyPathology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, ItalyOrthopedic and Traumatology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, ItalyOrthopaedic Oncology Unit, IRCCS Istituto Ortopedico Rizzoli, Via Pupilli 1, 40136 Bologna, ItalyDiffuse type tenosynovial giant cell tumor (D-TGCT) of the knee presents with stiffness, pain and swelling with surgery being the mainstay treatment. However, the literature lacks data on clinical course of range of motion, pain (ROM), and swelling after open synovectomy for D-TGCT. Therefore, this study aims to evaluate clinical course after open anterior synovectomy. A retrospective analysis was conducted on 214 patients treated for TGCT at our Institutions between 2010 and 2023. 51 patients with anterior knee D-TGCT who underwent open anterior synovectomy were included. Pre- and postoperative assessments included ROM, pain (VAS scale), and reported swelling. The mean knee flexion increased from 100° (SD 14.28) preoperatively to 131.8° (12.64) at 12 months post-surgery. Knee extension remained stable, ranging from 178.4° preoperatively to 179.2° at the final follow-up. Pain decreased from a mean of 5.0 (SD 2.8) preoperatively to 0.5 (SD 0.7) at 12 months. Swelling was initially reported in 90.4% of patients, with 95.74% of them showing improvement at six months, and 100% at 12 months. Open anterior synovectomy effectively improves knee function, pain, swelling in patients with anterior knee D-TGCT, although functional recovery may take up to 6–12 months.https://www.mdpi.com/1718-7729/32/6/342tenosynovial giant cell tumorpigmented villonodular synovitisrange of motionpainswelling |
| spellingShingle | Alessandro Bruschi Eric Staals Andrea Sambri Luca Cevolani Marco Gambarotti Alberto Righi Michele Fiore Eleonora Villari Stefano Pasini Maria Giulia Pirini Massimiliano De Paolis Davide Maria Donati Diffuse-Type Tenosynovial Giant Cell Tumor of the Knee: Clinical Course After Anterior Open Synovectomy Current Oncology tenosynovial giant cell tumor pigmented villonodular synovitis range of motion pain swelling |
| title | Diffuse-Type Tenosynovial Giant Cell Tumor of the Knee: Clinical Course After Anterior Open Synovectomy |
| title_full | Diffuse-Type Tenosynovial Giant Cell Tumor of the Knee: Clinical Course After Anterior Open Synovectomy |
| title_fullStr | Diffuse-Type Tenosynovial Giant Cell Tumor of the Knee: Clinical Course After Anterior Open Synovectomy |
| title_full_unstemmed | Diffuse-Type Tenosynovial Giant Cell Tumor of the Knee: Clinical Course After Anterior Open Synovectomy |
| title_short | Diffuse-Type Tenosynovial Giant Cell Tumor of the Knee: Clinical Course After Anterior Open Synovectomy |
| title_sort | diffuse type tenosynovial giant cell tumor of the knee clinical course after anterior open synovectomy |
| topic | tenosynovial giant cell tumor pigmented villonodular synovitis range of motion pain swelling |
| url | https://www.mdpi.com/1718-7729/32/6/342 |
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