Where Are We Heading with Noninvasive Clinical Vascular Physiology? Why and How Should We Assess Endothelial Function?
There are several invasive and noninvasive methods available to the clinical researcher for the assessment of endothelial function. The first investigations in humans involved invasive pharmacological vascular function testing, which have been used to gain a detailed understanding of the mechanisms...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Cardiology Research and Practice |
| Online Access: | http://dx.doi.org/10.4061/2011/870132 |
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| _version_ | 1832551705599803392 |
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| author | Elizabeth A. Ellins Julian P. J. Halcox |
| author_facet | Elizabeth A. Ellins Julian P. J. Halcox |
| author_sort | Elizabeth A. Ellins |
| collection | DOAJ |
| description | There are several invasive and noninvasive methods available to the clinical researcher for the assessment of endothelial function. The first investigations in humans involved invasive pharmacological vascular function testing, which have been used to gain a detailed understanding of the mechanisms involved in the pathogenesis of endothelial dysfunction and atherosclerosis as well as novel targets for intervention. Techniques for endothelial function testing have evolved over time from these invasive methods, which, by their nature, are restricted to small studies in the research laboratory, to more standardized noninvasive methods, which are suitable for use in large prospective cohort studies and clinical trials. This paper describes currently available methods for assessment of endothelial function and their potential application in cardiovascular research and clinical practice. |
| format | Article |
| id | doaj-art-e27cdd6f684048dba68a49c4b02f3246 |
| institution | Kabale University |
| issn | 2090-0597 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cardiology Research and Practice |
| spelling | doaj-art-e27cdd6f684048dba68a49c4b02f32462025-02-03T06:00:46ZengWileyCardiology Research and Practice2090-05972011-01-01201110.4061/2011/870132870132Where Are We Heading with Noninvasive Clinical Vascular Physiology? Why and How Should We Assess Endothelial Function?Elizabeth A. Ellins0Julian P. J. Halcox1Wales Heart Research Institute, Cardiff University, Heath Park, Cardiff CF14 4XN, UKWales Heart Research Institute, Cardiff University, Heath Park, Cardiff CF14 4XN, UKThere are several invasive and noninvasive methods available to the clinical researcher for the assessment of endothelial function. The first investigations in humans involved invasive pharmacological vascular function testing, which have been used to gain a detailed understanding of the mechanisms involved in the pathogenesis of endothelial dysfunction and atherosclerosis as well as novel targets for intervention. Techniques for endothelial function testing have evolved over time from these invasive methods, which, by their nature, are restricted to small studies in the research laboratory, to more standardized noninvasive methods, which are suitable for use in large prospective cohort studies and clinical trials. This paper describes currently available methods for assessment of endothelial function and their potential application in cardiovascular research and clinical practice.http://dx.doi.org/10.4061/2011/870132 |
| spellingShingle | Elizabeth A. Ellins Julian P. J. Halcox Where Are We Heading with Noninvasive Clinical Vascular Physiology? Why and How Should We Assess Endothelial Function? Cardiology Research and Practice |
| title | Where Are We Heading with Noninvasive Clinical Vascular Physiology? Why and How Should We Assess Endothelial Function? |
| title_full | Where Are We Heading with Noninvasive Clinical Vascular Physiology? Why and How Should We Assess Endothelial Function? |
| title_fullStr | Where Are We Heading with Noninvasive Clinical Vascular Physiology? Why and How Should We Assess Endothelial Function? |
| title_full_unstemmed | Where Are We Heading with Noninvasive Clinical Vascular Physiology? Why and How Should We Assess Endothelial Function? |
| title_short | Where Are We Heading with Noninvasive Clinical Vascular Physiology? Why and How Should We Assess Endothelial Function? |
| title_sort | where are we heading with noninvasive clinical vascular physiology why and how should we assess endothelial function |
| url | http://dx.doi.org/10.4061/2011/870132 |
| work_keys_str_mv | AT elizabethaellins whereareweheadingwithnoninvasiveclinicalvascularphysiologywhyandhowshouldweassessendothelialfunction AT julianpjhalcox whereareweheadingwithnoninvasiveclinicalvascularphysiologywhyandhowshouldweassessendothelialfunction |