Spermidine Enhances Mitochondrial Bioenergetics in Young and Aged Human-Induced Pluripotent Stem Cell-Derived Neurons

Spermidine Enhances Mitochondrial Bioenergetics in Young and Aged Human-Induced Pluripotent Stem Cell-Derived Neurons

The accumulation of damaged mitochondria has long been considered a hallmark of the aging process. Among various factors, age-related mitochondrial alterations comprise bioenergetic impairments and disturbances in reactive oxygen species (ROS) control, thereby negatively affecting mitochondrial perf...

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Bibliographic Details
Main Authors: Leonora Szabo, Imane Lejri, Amandine Grimm, Anne Eckert
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Antioxidants
Subjects:
spermidine
aging
induced pluripotent stem cell-derived neurons
mitochondria
bioenergetics
oxidative stress
Online Access:https://www.mdpi.com/2076-3921/13/12/1482
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