Screening for Hypoglycemic Activity on the Leaf Extracts of Nine Medicinal Plants: In-Vivo Evaluation
The traditional use of certain plants by the tribal community in central India involves using the young leaves for several ailments, including hyperglycaemia; this study was performed to evaluate the effects of the leaf extracts from 9 such plants in the management of diabetes. Initially, hypoglycem...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2012/103760 |
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| author | Aditya Arya Mahmood Ameen Abdullah Batoul Sadat Haerian Mustafa Ali Mohd |
| author_facet | Aditya Arya Mahmood Ameen Abdullah Batoul Sadat Haerian Mustafa Ali Mohd |
| author_sort | Aditya Arya |
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| description | The traditional use of certain plants by the tribal community in central India involves using the young leaves for several ailments, including hyperglycaemia; this study was performed to evaluate the effects of the leaf extracts from 9 such plants in the management of diabetes. Initially, hypoglycemic screening was performed on normal rats whose blood glucose levels were measured before and after oral or intraperitoneal (i.p.) administration of the extracts at different periods. The plants were screened at doses of 250 mg/kg i.p. or 500 mg/kg orally. Of these, only Centratherum anthelminticum (Asteraceae), Cissus quadrangularis (Vitaceae), and Woodfordia fruticosa Kurz (Lythraceae) significantly reduced postprandial blood glucose levels in normal glycemic rats (P < 0.001), with slight reductions effected by Sida acuta Burm F. (P = 0.002) and Parthenium hysterophorus L. (P = 0.017). The extracts that reduced postprandial blood glucose levels both orally and i.p. in the hypoglycemic screening tests were evaluated for glucose challenge in glucose tolerance tests with i.p and oral administration in overnight-fasted normal rats. The results of these tests potentiate the screening data in the management of diabetes mellitus, which requires further studies on the plants that yielded positive results to determine the active compounds in the different plant parts that are responsible for the activity. |
| format | Article |
| id | doaj-art-e2778dad0cb144138baedcf22249c909 |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-e2778dad0cb144138baedcf22249c9092025-02-03T01:33:14ZengWileyE-Journal of Chemistry0973-49452090-98102012-01-01931196120510.1155/2012/103760Screening for Hypoglycemic Activity on the Leaf Extracts of Nine Medicinal Plants: In-Vivo EvaluationAditya Arya0Mahmood Ameen Abdullah1Batoul Sadat Haerian2Mustafa Ali Mohd3Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia3Department of Molecular Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, MalaysiaDepartment of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, MalaysiaDepartment of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, MalaysiaThe traditional use of certain plants by the tribal community in central India involves using the young leaves for several ailments, including hyperglycaemia; this study was performed to evaluate the effects of the leaf extracts from 9 such plants in the management of diabetes. Initially, hypoglycemic screening was performed on normal rats whose blood glucose levels were measured before and after oral or intraperitoneal (i.p.) administration of the extracts at different periods. The plants were screened at doses of 250 mg/kg i.p. or 500 mg/kg orally. Of these, only Centratherum anthelminticum (Asteraceae), Cissus quadrangularis (Vitaceae), and Woodfordia fruticosa Kurz (Lythraceae) significantly reduced postprandial blood glucose levels in normal glycemic rats (P < 0.001), with slight reductions effected by Sida acuta Burm F. (P = 0.002) and Parthenium hysterophorus L. (P = 0.017). The extracts that reduced postprandial blood glucose levels both orally and i.p. in the hypoglycemic screening tests were evaluated for glucose challenge in glucose tolerance tests with i.p and oral administration in overnight-fasted normal rats. The results of these tests potentiate the screening data in the management of diabetes mellitus, which requires further studies on the plants that yielded positive results to determine the active compounds in the different plant parts that are responsible for the activity.http://dx.doi.org/10.1155/2012/103760 |
| spellingShingle | Aditya Arya Mahmood Ameen Abdullah Batoul Sadat Haerian Mustafa Ali Mohd Screening for Hypoglycemic Activity on the Leaf Extracts of Nine Medicinal Plants: In-Vivo Evaluation E-Journal of Chemistry |
| title | Screening for Hypoglycemic Activity on the Leaf Extracts of Nine Medicinal Plants: In-Vivo Evaluation |
| title_full | Screening for Hypoglycemic Activity on the Leaf Extracts of Nine Medicinal Plants: In-Vivo Evaluation |
| title_fullStr | Screening for Hypoglycemic Activity on the Leaf Extracts of Nine Medicinal Plants: In-Vivo Evaluation |
| title_full_unstemmed | Screening for Hypoglycemic Activity on the Leaf Extracts of Nine Medicinal Plants: In-Vivo Evaluation |
| title_short | Screening for Hypoglycemic Activity on the Leaf Extracts of Nine Medicinal Plants: In-Vivo Evaluation |
| title_sort | screening for hypoglycemic activity on the leaf extracts of nine medicinal plants in vivo evaluation |
| url | http://dx.doi.org/10.1155/2012/103760 |
| work_keys_str_mv | AT adityaarya screeningforhypoglycemicactivityontheleafextractsofninemedicinalplantsinvivoevaluation AT mahmoodameenabdullah screeningforhypoglycemicactivityontheleafextractsofninemedicinalplantsinvivoevaluation AT batoulsadathaerian screeningforhypoglycemicactivityontheleafextractsofninemedicinalplantsinvivoevaluation AT mustafaalimohd screeningforhypoglycemicactivityontheleafextractsofninemedicinalplantsinvivoevaluation |