Branched-chain amino acids levels associated with risk of erectile dysfunction: A Mendelian randomization analysis
Background: Erectile dysfunction (ED) is a prevalent male sexual dysfunction that remarkably impacts patients' quality of life and is also recognized as a precursor to cardiovascular disease (CVD) events. Branched-chain amino acids (BCAAs) are derived from dietary intake and mainly involved in...
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| Language: | English |
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Elsevier
2025-02-01
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| Series: | Experimental Gerontology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0531556525000051 |
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| author | Yijian Deng Liying Zeng Yigui Lai Shuai Ji Baizhao Peng Hanqi Lu Ming Wang Hiu Yee Kwan Qi Wang Xiaoshan Zhao |
| author_facet | Yijian Deng Liying Zeng Yigui Lai Shuai Ji Baizhao Peng Hanqi Lu Ming Wang Hiu Yee Kwan Qi Wang Xiaoshan Zhao |
| author_sort | Yijian Deng |
| collection | DOAJ |
| description | Background: Erectile dysfunction (ED) is a prevalent male sexual dysfunction that remarkably impacts patients' quality of life and is also recognized as a precursor to cardiovascular disease (CVD) events. Branched-chain amino acids (BCAAs) are derived from dietary intake and mainly involved in energy metabolism. Previous studies have underscored the association between BCAAs and CVD, but the causal link between BCAAs and ED remains uncertain. Methods: The bidirectional Mendelian randomization (MR) study used the genetic data from genome-wide association studies (GWAS) to identify single nucleotide polymorphisms (SNPs) associated with total BCAAs, leucine, isoleucine, and valine. The genetic data for ED were acquired from the FinnGen study (n = 95,178). The primary method used to assess causal associations was the inverse variance-weighted (IVW) method, supplemented by MR-Egger, weighted median, and simple median analyses. Cochrane's Q test was utilized to evaluate heterogeneity within the results, while the MR-Egger intercept test was utilized to evaluate the Level pleiotropy. A sensitivity analysis was performed employing leave-one-out analysis. Results: The MR analysis results indicate a positive correlation between levels of total BCAA (OR = 1.984, 95 % CI = 1.018–3.868, P = 0.044), leucine (OR = 2.277, 95 % CI = 1.121–4.626, P = 0.023), isoleucine (OR = 2.584, 95 % CI = 1.167–5.722, P = 0.019), valine (OR = 1.894, 95 % CI = 1.119–3.206, P = 0.017), and the risk of ED. Sensitivity tests confirmed the accuracy and robustness of the study findings. Moreover, the reverse MR analysis found no association between ED and the BCAAs. Conclusion: The results of this analysis indicate a positive association between the circulating BCAA concentrations and the risk of ED, but their underlying mechanisms require further investigation. |
| format | Article |
| id | doaj-art-e27668ef01d04dc3b2bf5c15931dc464 |
| institution | Kabale University |
| issn | 1873-6815 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Experimental Gerontology |
| spelling | doaj-art-e27668ef01d04dc3b2bf5c15931dc4642025-01-31T05:10:07ZengElsevierExperimental Gerontology1873-68152025-02-01200112677Branched-chain amino acids levels associated with risk of erectile dysfunction: A Mendelian randomization analysisYijian Deng0Liying Zeng1Yigui Lai2Shuai Ji3Baizhao Peng4Hanqi Lu5Ming Wang6Hiu Yee Kwan7Qi Wang8Xiaoshan Zhao9Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong 510282, ChinaSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong 510515, ChinaPeople's Hospital of Yangjiang, Yangjiang 529500, ChinaSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong 510515, ChinaSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong 510515, ChinaDongguan Hospital of Traditional Chinese Medicine, Dongguan, Guangdong 523000, ChinaZhujiang Hospital, Southern Medical University, Guangzhou, Guangdong 510282, ChinaSchool of Chinese Medicine, Hong Kong Baptist University, Hong Kong, ChinaSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong 510515, China; Corresponding author.Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong 510282, China; School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong 510515, China; Corresponding author at: Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong 510280, China.Background: Erectile dysfunction (ED) is a prevalent male sexual dysfunction that remarkably impacts patients' quality of life and is also recognized as a precursor to cardiovascular disease (CVD) events. Branched-chain amino acids (BCAAs) are derived from dietary intake and mainly involved in energy metabolism. Previous studies have underscored the association between BCAAs and CVD, but the causal link between BCAAs and ED remains uncertain. Methods: The bidirectional Mendelian randomization (MR) study used the genetic data from genome-wide association studies (GWAS) to identify single nucleotide polymorphisms (SNPs) associated with total BCAAs, leucine, isoleucine, and valine. The genetic data for ED were acquired from the FinnGen study (n = 95,178). The primary method used to assess causal associations was the inverse variance-weighted (IVW) method, supplemented by MR-Egger, weighted median, and simple median analyses. Cochrane's Q test was utilized to evaluate heterogeneity within the results, while the MR-Egger intercept test was utilized to evaluate the Level pleiotropy. A sensitivity analysis was performed employing leave-one-out analysis. Results: The MR analysis results indicate a positive correlation between levels of total BCAA (OR = 1.984, 95 % CI = 1.018–3.868, P = 0.044), leucine (OR = 2.277, 95 % CI = 1.121–4.626, P = 0.023), isoleucine (OR = 2.584, 95 % CI = 1.167–5.722, P = 0.019), valine (OR = 1.894, 95 % CI = 1.119–3.206, P = 0.017), and the risk of ED. Sensitivity tests confirmed the accuracy and robustness of the study findings. Moreover, the reverse MR analysis found no association between ED and the BCAAs. Conclusion: The results of this analysis indicate a positive association between the circulating BCAA concentrations and the risk of ED, but their underlying mechanisms require further investigation.http://www.sciencedirect.com/science/article/pii/S0531556525000051Branched-chain amino acidErectile dysfunctionMendelian randomizationGWASSingle nucleotide polymorphisms |
| spellingShingle | Yijian Deng Liying Zeng Yigui Lai Shuai Ji Baizhao Peng Hanqi Lu Ming Wang Hiu Yee Kwan Qi Wang Xiaoshan Zhao Branched-chain amino acids levels associated with risk of erectile dysfunction: A Mendelian randomization analysis Experimental Gerontology Branched-chain amino acid Erectile dysfunction Mendelian randomization GWAS Single nucleotide polymorphisms |
| title | Branched-chain amino acids levels associated with risk of erectile dysfunction: A Mendelian randomization analysis |
| title_full | Branched-chain amino acids levels associated with risk of erectile dysfunction: A Mendelian randomization analysis |
| title_fullStr | Branched-chain amino acids levels associated with risk of erectile dysfunction: A Mendelian randomization analysis |
| title_full_unstemmed | Branched-chain amino acids levels associated with risk of erectile dysfunction: A Mendelian randomization analysis |
| title_short | Branched-chain amino acids levels associated with risk of erectile dysfunction: A Mendelian randomization analysis |
| title_sort | branched chain amino acids levels associated with risk of erectile dysfunction a mendelian randomization analysis |
| topic | Branched-chain amino acid Erectile dysfunction Mendelian randomization GWAS Single nucleotide polymorphisms |
| url | http://www.sciencedirect.com/science/article/pii/S0531556525000051 |
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