IKZF1 as a potential therapeutic target for dendritic cell-mediated immunotherapy in IgA nephropathy

IKZF1 as a potential therapeutic target for dendritic cell-mediated immunotherapy in IgA nephropathy

Abstract Background Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis globally and a major cause of renal failure. Immune dysregulation drives its pathogenesis. This study identifies novel genes as potential diagnostic and therapeutic targets, elucidating immune mecha...

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Main Authors: Fei Peng, Chunjia Sheng, Jiayi He, Yena Zhou, Yilun Qu, Shuwei Duan, Yinghua Zhao, Jikai Xia, Jie Wu, Guangyan Cai, Lingling Wu, Chuyue Zhang, Xiangmei Chen
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Cell Communication and Signaling
Subjects:
Computational biology
Dendritic cells
Immunoglobulin A nephropathy
IKZF1
Biomarkers
Online Access:https://doi.org/10.1186/s12964-025-02196-x
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