The application prospects of sacha inchi (Plukenetia volubilis linneo) in rheumatoid arthritis
Sacha Inchi (Plukenetia volubilis L) (SI) is a traditional natural medicine from tropical rainforests of Amazon region in South America. As a raw material for edible oil, it has various pharmacological effects such as antioxidant, anti-inflammatory, hypolipidemia, and blood pressure lowering, which...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2024-10-01
|
| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2024.1481272/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850184608611565568 |
|---|---|
| author | Min Wang Min Wang Yin-Hong Xiang Mei Liu Mei Liu Shan Jiang Jia-ying Guo Xiao-yan Jin Hui-feng Sun Ning Zhang Ning Zhang Zhi-Gang Wang Jian-xin Liu Jian-xin Liu |
| author_facet | Min Wang Min Wang Yin-Hong Xiang Mei Liu Mei Liu Shan Jiang Jia-ying Guo Xiao-yan Jin Hui-feng Sun Ning Zhang Ning Zhang Zhi-Gang Wang Jian-xin Liu Jian-xin Liu |
| author_sort | Min Wang |
| collection | DOAJ |
| description | Sacha Inchi (Plukenetia volubilis L) (SI) is a traditional natural medicine from tropical rainforests of Amazon region in South America. As a raw material for edible oil, it has various pharmacological effects such as antioxidant, anti-inflammatory, hypolipidemia, and blood pressure lowering, which have attracted increasing attentions of pharmacists. This has prompted researchers to explore its pharmacological effects for potential applications in certain diseases. Among these, the study of its anti-inflammatory effects has become a particularly interesting topic, especially in rheumatoid arthritis (RA). RA is a systemic autoimmune disease, and often accompanied by chronic inflammatory reactions. Despite significant progress in its treatment, there is still an urgent need to find effective anti-RA drugs in regard to safety. This review summarizes the potential therapeutic effects of SI on RA by modulating gut microbiota, targeting inflammatory cells and pathways, and mimicking biologic antibody drugs, predicting the application prospects of SI in RA, and providing references for research aimed at using SI to treat RA. |
| format | Article |
| id | doaj-art-e26ba094890646278dba76d4954b3683 |
| institution | OA Journals |
| issn | 1663-9812 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-e26ba094890646278dba76d4954b36832025-08-20T02:17:00ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122024-10-011510.3389/fphar.2024.14812721481272The application prospects of sacha inchi (Plukenetia volubilis linneo) in rheumatoid arthritisMin Wang0Min Wang1Yin-Hong Xiang2Mei Liu3Mei Liu4Shan Jiang5Jia-ying Guo6Xiao-yan Jin7Hui-feng Sun8Ning Zhang9Ning Zhang10Zhi-Gang Wang11Jian-xin Liu12Jian-xin Liu13School of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, ChinaSino-Pakistan Center on Traditional Chinese Medicine, School of Pharmaceutical Sciences, School of Basic Medical Sciences, China-Pakistan International Science and Technology Innovation Cooperation Base for Ethnic Medicine Development in Hunan Province, Hunan University of Medicine, Huaihua, Hunan, ChinaSino-Pakistan Center on Traditional Chinese Medicine, School of Pharmaceutical Sciences, School of Basic Medical Sciences, China-Pakistan International Science and Technology Innovation Cooperation Base for Ethnic Medicine Development in Hunan Province, Hunan University of Medicine, Huaihua, Hunan, ChinaSino-Pakistan Center on Traditional Chinese Medicine, School of Pharmaceutical Sciences, School of Basic Medical Sciences, China-Pakistan International Science and Technology Innovation Cooperation Base for Ethnic Medicine Development in Hunan Province, Hunan University of Medicine, Huaihua, Hunan, ChinaSchool of Pharmaceutical Sciences, University of South China, Hengyang, Hunan, ChinaSchool of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, ChinaSchool of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, ChinaSchool of Pharmaceutical Sciences, Xinjiang medical University, Wulumuqi, Xinjiang, ChinaSchool of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, ChinaSchool of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, ChinaSino-Pakistan Center on Traditional Chinese Medicine, School of Pharmaceutical Sciences, School of Basic Medical Sciences, China-Pakistan International Science and Technology Innovation Cooperation Base for Ethnic Medicine Development in Hunan Province, Hunan University of Medicine, Huaihua, Hunan, ChinaSchool of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, ChinaSino-Pakistan Center on Traditional Chinese Medicine, School of Pharmaceutical Sciences, School of Basic Medical Sciences, China-Pakistan International Science and Technology Innovation Cooperation Base for Ethnic Medicine Development in Hunan Province, Hunan University of Medicine, Huaihua, Hunan, ChinaSchool of Pharmaceutical Sciences, University of South China, Hengyang, Hunan, ChinaSacha Inchi (Plukenetia volubilis L) (SI) is a traditional natural medicine from tropical rainforests of Amazon region in South America. As a raw material for edible oil, it has various pharmacological effects such as antioxidant, anti-inflammatory, hypolipidemia, and blood pressure lowering, which have attracted increasing attentions of pharmacists. This has prompted researchers to explore its pharmacological effects for potential applications in certain diseases. Among these, the study of its anti-inflammatory effects has become a particularly interesting topic, especially in rheumatoid arthritis (RA). RA is a systemic autoimmune disease, and often accompanied by chronic inflammatory reactions. Despite significant progress in its treatment, there is still an urgent need to find effective anti-RA drugs in regard to safety. This review summarizes the potential therapeutic effects of SI on RA by modulating gut microbiota, targeting inflammatory cells and pathways, and mimicking biologic antibody drugs, predicting the application prospects of SI in RA, and providing references for research aimed at using SI to treat RA.https://www.frontiersin.org/articles/10.3389/fphar.2024.1481272/fullPlukenetia volubilis linneosacha inchirheumatoid arthritisinflammationantioxidantgut microbiota |
| spellingShingle | Min Wang Min Wang Yin-Hong Xiang Mei Liu Mei Liu Shan Jiang Jia-ying Guo Xiao-yan Jin Hui-feng Sun Ning Zhang Ning Zhang Zhi-Gang Wang Jian-xin Liu Jian-xin Liu The application prospects of sacha inchi (Plukenetia volubilis linneo) in rheumatoid arthritis Frontiers in Pharmacology Plukenetia volubilis linneo sacha inchi rheumatoid arthritis inflammation antioxidant gut microbiota |
| title | The application prospects of sacha inchi (Plukenetia volubilis linneo) in rheumatoid arthritis |
| title_full | The application prospects of sacha inchi (Plukenetia volubilis linneo) in rheumatoid arthritis |
| title_fullStr | The application prospects of sacha inchi (Plukenetia volubilis linneo) in rheumatoid arthritis |
| title_full_unstemmed | The application prospects of sacha inchi (Plukenetia volubilis linneo) in rheumatoid arthritis |
| title_short | The application prospects of sacha inchi (Plukenetia volubilis linneo) in rheumatoid arthritis |
| title_sort | application prospects of sacha inchi plukenetia volubilis linneo in rheumatoid arthritis |
| topic | Plukenetia volubilis linneo sacha inchi rheumatoid arthritis inflammation antioxidant gut microbiota |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2024.1481272/full |
| work_keys_str_mv | AT minwang theapplicationprospectsofsachainchiplukenetiavolubilislinneoinrheumatoidarthritis AT minwang theapplicationprospectsofsachainchiplukenetiavolubilislinneoinrheumatoidarthritis AT yinhongxiang theapplicationprospectsofsachainchiplukenetiavolubilislinneoinrheumatoidarthritis AT meiliu theapplicationprospectsofsachainchiplukenetiavolubilislinneoinrheumatoidarthritis AT meiliu theapplicationprospectsofsachainchiplukenetiavolubilislinneoinrheumatoidarthritis AT shanjiang theapplicationprospectsofsachainchiplukenetiavolubilislinneoinrheumatoidarthritis AT jiayingguo theapplicationprospectsofsachainchiplukenetiavolubilislinneoinrheumatoidarthritis AT xiaoyanjin theapplicationprospectsofsachainchiplukenetiavolubilislinneoinrheumatoidarthritis AT huifengsun theapplicationprospectsofsachainchiplukenetiavolubilislinneoinrheumatoidarthritis AT ningzhang theapplicationprospectsofsachainchiplukenetiavolubilislinneoinrheumatoidarthritis AT ningzhang theapplicationprospectsofsachainchiplukenetiavolubilislinneoinrheumatoidarthritis AT zhigangwang theapplicationprospectsofsachainchiplukenetiavolubilislinneoinrheumatoidarthritis AT jianxinliu theapplicationprospectsofsachainchiplukenetiavolubilislinneoinrheumatoidarthritis AT jianxinliu theapplicationprospectsofsachainchiplukenetiavolubilislinneoinrheumatoidarthritis AT minwang applicationprospectsofsachainchiplukenetiavolubilislinneoinrheumatoidarthritis AT minwang applicationprospectsofsachainchiplukenetiavolubilislinneoinrheumatoidarthritis AT yinhongxiang applicationprospectsofsachainchiplukenetiavolubilislinneoinrheumatoidarthritis AT meiliu applicationprospectsofsachainchiplukenetiavolubilislinneoinrheumatoidarthritis AT meiliu applicationprospectsofsachainchiplukenetiavolubilislinneoinrheumatoidarthritis AT shanjiang applicationprospectsofsachainchiplukenetiavolubilislinneoinrheumatoidarthritis AT jiayingguo applicationprospectsofsachainchiplukenetiavolubilislinneoinrheumatoidarthritis AT xiaoyanjin applicationprospectsofsachainchiplukenetiavolubilislinneoinrheumatoidarthritis AT huifengsun applicationprospectsofsachainchiplukenetiavolubilislinneoinrheumatoidarthritis AT ningzhang applicationprospectsofsachainchiplukenetiavolubilislinneoinrheumatoidarthritis AT ningzhang applicationprospectsofsachainchiplukenetiavolubilislinneoinrheumatoidarthritis AT zhigangwang applicationprospectsofsachainchiplukenetiavolubilislinneoinrheumatoidarthritis AT jianxinliu applicationprospectsofsachainchiplukenetiavolubilislinneoinrheumatoidarthritis AT jianxinliu applicationprospectsofsachainchiplukenetiavolubilislinneoinrheumatoidarthritis |