Research progress on fecal microbiota transplantation in tumor prevention and treatment
The application of fecal microbiota transplantation (FMT) as a therapeutic strategy to directly modify the makeup of the gut microbiota has made significant progress in the last few decades. The gut microbiota, a sizable microbial community present in the human gut, is essential for digestion, immun...
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| Format: | Article |
| Language: | English |
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De Gruyter
2025-04-01
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| Series: | Open Life Sciences |
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| Online Access: | https://doi.org/10.1515/biol-2022-0954 |
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| author | Wu Yijia Chen Xi Wu Qingming Wang Qiang |
| author_facet | Wu Yijia Chen Xi Wu Qingming Wang Qiang |
| author_sort | Wu Yijia |
| collection | DOAJ |
| description | The application of fecal microbiota transplantation (FMT) as a therapeutic strategy to directly modify the makeup of the gut microbiota has made significant progress in the last few decades. The gut microbiota, a sizable microbial community present in the human gut, is essential for digestion, immunomodulation, and nutrition absorption. Alternatively, a growing body of research indicates that gut microbiota is a key contributor to cancer, and intratumoral bacteria are considered to be crucial “accomplices” in the development and metastasis of malignancies. The exceptional clinical effectiveness of FMT in treating melanoma patients has been adequately established in earlier research, which has created new avenues for the diagnosis and treatment of cancer and sparked an increasing interest in the treatment and prevention of other cancers. However, further research on the function and mechanisms of the gut microbiota is required to properly comprehend the impact and role of these organisms in tumor regulation. In this article, we present a detailed account of the influence of FMT on the entire course of cancer patients’ illness and treatment, from tumor development, metastasis, and invasion, to the impact and application of treatment and prognosis, as well as address the associated mechanisms. |
| format | Article |
| id | doaj-art-e269e64191694c5daab68033b6ab6906 |
| institution | OA Journals |
| issn | 2391-5412 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Life Sciences |
| spelling | doaj-art-e269e64191694c5daab68033b6ab69062025-08-20T01:54:16ZengDe GruyterOpen Life Sciences2391-54122025-04-0120130546310.1515/biol-2022-0954Research progress on fecal microbiota transplantation in tumor prevention and treatmentWu Yijia0Chen Xi1Wu Qingming2Wang Qiang3Wuchang Hospital Affiliated to Wuhan University of Science and Technology, Medical College, Wuhan University of Science and Technology, Wuhan, 430065, ChinaWuchang Hospital Affiliated to Wuhan University of Science and Technology, Medical College, Wuhan University of Science and Technology, Wuhan, 430065, ChinaWuchang Hospital Affiliated to Wuhan University of Science and Technology, Medical College, Wuhan University of Science and Technology, Wuhan, 430065, ChinaWuchang Hospital Affiliated to Wuhan University of Science and Technology, Medical College, Wuhan University of Science and Technology, Wuhan, 430065, ChinaThe application of fecal microbiota transplantation (FMT) as a therapeutic strategy to directly modify the makeup of the gut microbiota has made significant progress in the last few decades. The gut microbiota, a sizable microbial community present in the human gut, is essential for digestion, immunomodulation, and nutrition absorption. Alternatively, a growing body of research indicates that gut microbiota is a key contributor to cancer, and intratumoral bacteria are considered to be crucial “accomplices” in the development and metastasis of malignancies. The exceptional clinical effectiveness of FMT in treating melanoma patients has been adequately established in earlier research, which has created new avenues for the diagnosis and treatment of cancer and sparked an increasing interest in the treatment and prevention of other cancers. However, further research on the function and mechanisms of the gut microbiota is required to properly comprehend the impact and role of these organisms in tumor regulation. In this article, we present a detailed account of the influence of FMT on the entire course of cancer patients’ illness and treatment, from tumor development, metastasis, and invasion, to the impact and application of treatment and prognosis, as well as address the associated mechanisms.https://doi.org/10.1515/biol-2022-0954gut microbiotadysbiosiscancerfecal microbiota transplantationtherapy |
| spellingShingle | Wu Yijia Chen Xi Wu Qingming Wang Qiang Research progress on fecal microbiota transplantation in tumor prevention and treatment Open Life Sciences gut microbiota dysbiosis cancer fecal microbiota transplantation therapy |
| title | Research progress on fecal microbiota transplantation in tumor prevention and treatment |
| title_full | Research progress on fecal microbiota transplantation in tumor prevention and treatment |
| title_fullStr | Research progress on fecal microbiota transplantation in tumor prevention and treatment |
| title_full_unstemmed | Research progress on fecal microbiota transplantation in tumor prevention and treatment |
| title_short | Research progress on fecal microbiota transplantation in tumor prevention and treatment |
| title_sort | research progress on fecal microbiota transplantation in tumor prevention and treatment |
| topic | gut microbiota dysbiosis cancer fecal microbiota transplantation therapy |
| url | https://doi.org/10.1515/biol-2022-0954 |
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