Quorum quenching: A key biological activity of marine actinobacteria extracts for acne vulgaris control
Quorum sensing (QS) regulates virulence factors in bacteria associated with acne vulgaris. Consequently, extracts from marine actinobacteria sourced from Colombian Caribbean sponges and octocorals were screened for quorum quenching (QQ) and anti-biofilm activity. The most promising extract, G12.218...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-09-01
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| Series: | Biotechnology Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2215017X2500030X |
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| author | María Clara De La Hoz-Romo Luis Díaz Javier Gómez-León Luis Felipe Reyes Marynes Quintero Luisa Villamil |
| author_facet | María Clara De La Hoz-Romo Luis Díaz Javier Gómez-León Luis Felipe Reyes Marynes Quintero Luisa Villamil |
| author_sort | María Clara De La Hoz-Romo |
| collection | DOAJ |
| description | Quorum sensing (QS) regulates virulence factors in bacteria associated with acne vulgaris. Consequently, extracts from marine actinobacteria sourced from Colombian Caribbean sponges and octocorals were screened for quorum quenching (QQ) and anti-biofilm activity. The most promising extract, G12.218 from Promicromonospora sp. CLIVUS-G12218, inhibited QS by 97 % via AI-2 signaling in Vibrio harveyi BB170 and reduced Staphylococcus aureus biofilm by 60 % at 3 mg/L, without cytotoxicity to keratinocytes and fibroblasts.Untargeted metabolomics of QQ active and non-active extracts revealed distinct profiles enriched in terpenoids, phenols, and butenolides, potentially linked to bioactivity. These extracts also exhibited antioxidant capacity (18 ± 0.23 µmol TE/L) and hyaluronidase inhibition up to 72.8 %, suggesting skin-protective properties. These findings highlight the potential of marine actinobacteria as a source of QQ and anti-biofilm agents for acne therapy and skincare. |
| format | Article |
| id | doaj-art-e268e8ed68b54fa9ba6431016e1ffd86 |
| institution | Kabale University |
| issn | 2215-017X |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biotechnology Reports |
| spelling | doaj-art-e268e8ed68b54fa9ba6431016e1ffd862025-08-20T03:46:50ZengElsevierBiotechnology Reports2215-017X2025-09-0147e0090310.1016/j.btre.2025.e00903Quorum quenching: A key biological activity of marine actinobacteria extracts for acne vulgaris controlMaría Clara De La Hoz-Romo0Luis Díaz1Javier Gómez-León2Luis Felipe Reyes3Marynes Quintero4Luisa Villamil5Doctoral Program of Biosciences, School of Engineering, Universidad de La Sabana, Chía 250001, Colombia; Bioprospecting Research Group, School of Engineering, Universidad de La Sabana, Chía 250001, ColombiaDoctoral Program of Biosciences, School of Engineering, Universidad de La Sabana, Chía 250001, Colombia; Bioprospecting Research Group, School of Engineering, Universidad de La Sabana, Chía 250001, ColombiaMarine Bioprospecting Line, Evaluation and Use of Marine and Coastal Resources Program –VAR, Instituto de Investigaciones Marinas y Costeras “José Benito Vives de Andréis” INVEMAR, Santa Marta, 470006, ColombiaUnisabana Center for Translational Science, School of Medicine, Universidad de La Sabana, Chia 250001 Colombia; Intensive Care Department, Clínica Universidad de La Sabana, Chia 250001, ColombiaMarine Bioprospecting Line, Evaluation and Use of Marine and Coastal Resources Program –VAR, Instituto de Investigaciones Marinas y Costeras “José Benito Vives de Andréis” INVEMAR, Santa Marta, 470006, ColombiaDoctoral Program of Biosciences, School of Engineering, Universidad de La Sabana, Chía 250001, Colombia; Corresponding author.Quorum sensing (QS) regulates virulence factors in bacteria associated with acne vulgaris. Consequently, extracts from marine actinobacteria sourced from Colombian Caribbean sponges and octocorals were screened for quorum quenching (QQ) and anti-biofilm activity. The most promising extract, G12.218 from Promicromonospora sp. CLIVUS-G12218, inhibited QS by 97 % via AI-2 signaling in Vibrio harveyi BB170 and reduced Staphylococcus aureus biofilm by 60 % at 3 mg/L, without cytotoxicity to keratinocytes and fibroblasts.Untargeted metabolomics of QQ active and non-active extracts revealed distinct profiles enriched in terpenoids, phenols, and butenolides, potentially linked to bioactivity. These extracts also exhibited antioxidant capacity (18 ± 0.23 µmol TE/L) and hyaluronidase inhibition up to 72.8 %, suggesting skin-protective properties. These findings highlight the potential of marine actinobacteria as a source of QQ and anti-biofilm agents for acne therapy and skincare.http://www.sciencedirect.com/science/article/pii/S2215017X2500030XMarine actinobacteriaQuorum QuenchingBiofilm inhibitionAcne vulgarisQuorum Sensing |
| spellingShingle | María Clara De La Hoz-Romo Luis Díaz Javier Gómez-León Luis Felipe Reyes Marynes Quintero Luisa Villamil Quorum quenching: A key biological activity of marine actinobacteria extracts for acne vulgaris control Biotechnology Reports Marine actinobacteria Quorum Quenching Biofilm inhibition Acne vulgaris Quorum Sensing |
| title | Quorum quenching: A key biological activity of marine actinobacteria extracts for acne vulgaris control |
| title_full | Quorum quenching: A key biological activity of marine actinobacteria extracts for acne vulgaris control |
| title_fullStr | Quorum quenching: A key biological activity of marine actinobacteria extracts for acne vulgaris control |
| title_full_unstemmed | Quorum quenching: A key biological activity of marine actinobacteria extracts for acne vulgaris control |
| title_short | Quorum quenching: A key biological activity of marine actinobacteria extracts for acne vulgaris control |
| title_sort | quorum quenching a key biological activity of marine actinobacteria extracts for acne vulgaris control |
| topic | Marine actinobacteria Quorum Quenching Biofilm inhibition Acne vulgaris Quorum Sensing |
| url | http://www.sciencedirect.com/science/article/pii/S2215017X2500030X |
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