Congenital Malformations in the Newborn Population: A Population Study and Analysis of the Effect of Sex and Prematurity
Congenital malformation (CM) is a leading cause of infant mortality. We hypothesized that the current estimates of the prevalence of CM are obsolete because of the increased rate of terminating fetuses with severe CMs and the widespread use of prenatal vitamins. Methods: This population-based cross-...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2015-02-01
|
| Series: | Pediatrics and Neonatology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1875957214001326 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850044831590514688 |
|---|---|
| author | Alexander Egbe Santosh Uppu Simon Lee Annemarie Stroustrup Deborah Ho Shubhika Srivastava |
| author_facet | Alexander Egbe Santosh Uppu Simon Lee Annemarie Stroustrup Deborah Ho Shubhika Srivastava |
| author_sort | Alexander Egbe |
| collection | DOAJ |
| description | Congenital malformation (CM) is a leading cause of infant mortality. We hypothesized that the current estimates of the prevalence of CM are obsolete because of the increased rate of terminating fetuses with severe CMs and the widespread use of prenatal vitamins.
Methods: This population-based cross-sectional study analyzed the effect of sex and prematurity on CM prevalence. All data were derived from birth entries in the 2008 Nationwide Inpatient Sample (NIS) database. Our objectives were to determine the prevalence of CM diagnoses among all birth hospitalizations in 2008 and to analyze the effect of sex and gestational maturity on CM prevalence.
Results: We identified 29,312 patients with CMs from among 1,014,261 live births, which yielded a CM prevalence of 28.9 per 1000 live births. Associated genetic syndromes were present in 1172 (4%) patients. Among newborns with nonsyndromic CM, 91% of newborns had an isolated CM and 9% of newborns had multiple CMs. The cardiovascular system was the most commonly involved organ system. The risk of CM was significantly higher in preterm newborns for an isolated CM [odds ratio (OR), 1.5; confidence interval (CI), 1.4–1.5]; multiple CMs (OR, 2.1; CI, 2.0–2.3); and overall CMs (OR, 1.4; CI, 1.3–1.5). Males had higher risk of isolated CMs (OR, 1.3; CI, 1.2–1.5). However, there was no sex difference in the risk of overall CM.
Conclusion: We reported up-to-date national estimates of the prevalence of CM, which is important for monitoring trends, determining service planning, and assessing disease burden because of congenital malformations in the United States of America. We also showed a strong association between CM and prematurity. Further study of this association is needed to provide insight into the etiology of these relatively common public health problems. |
| format | Article |
| id | doaj-art-e268a9abe263489293412ca98dda850d |
| institution | DOAJ |
| issn | 1875-9572 |
| language | English |
| publishDate | 2015-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pediatrics and Neonatology |
| spelling | doaj-art-e268a9abe263489293412ca98dda850d2025-08-20T02:54:50ZengElsevierPediatrics and Neonatology1875-95722015-02-01561253010.1016/j.pedneo.2014.03.010Congenital Malformations in the Newborn Population: A Population Study and Analysis of the Effect of Sex and PrematurityAlexander Egbe0Santosh Uppu1Simon Lee2Annemarie Stroustrup3Deborah Ho4Shubhika Srivastava5Mount Sinai Medical Center, New York, NY, USAMount Sinai Medical Center, New York, NY, USAMount Sinai Medical Center, New York, NY, USAMount Sinai Medical Center, New York, NY, USAMount Sinai Medical Center, New York, NY, USAMount Sinai Medical Center, New York, NY, USACongenital malformation (CM) is a leading cause of infant mortality. We hypothesized that the current estimates of the prevalence of CM are obsolete because of the increased rate of terminating fetuses with severe CMs and the widespread use of prenatal vitamins. Methods: This population-based cross-sectional study analyzed the effect of sex and prematurity on CM prevalence. All data were derived from birth entries in the 2008 Nationwide Inpatient Sample (NIS) database. Our objectives were to determine the prevalence of CM diagnoses among all birth hospitalizations in 2008 and to analyze the effect of sex and gestational maturity on CM prevalence. Results: We identified 29,312 patients with CMs from among 1,014,261 live births, which yielded a CM prevalence of 28.9 per 1000 live births. Associated genetic syndromes were present in 1172 (4%) patients. Among newborns with nonsyndromic CM, 91% of newborns had an isolated CM and 9% of newborns had multiple CMs. The cardiovascular system was the most commonly involved organ system. The risk of CM was significantly higher in preterm newborns for an isolated CM [odds ratio (OR), 1.5; confidence interval (CI), 1.4–1.5]; multiple CMs (OR, 2.1; CI, 2.0–2.3); and overall CMs (OR, 1.4; CI, 1.3–1.5). Males had higher risk of isolated CMs (OR, 1.3; CI, 1.2–1.5). However, there was no sex difference in the risk of overall CM. Conclusion: We reported up-to-date national estimates of the prevalence of CM, which is important for monitoring trends, determining service planning, and assessing disease burden because of congenital malformations in the United States of America. We also showed a strong association between CM and prematurity. Further study of this association is needed to provide insight into the etiology of these relatively common public health problems.http://www.sciencedirect.com/science/article/pii/S1875957214001326congenital malformationneonatal outcomenewbornpretermsex difference |
| spellingShingle | Alexander Egbe Santosh Uppu Simon Lee Annemarie Stroustrup Deborah Ho Shubhika Srivastava Congenital Malformations in the Newborn Population: A Population Study and Analysis of the Effect of Sex and Prematurity Pediatrics and Neonatology congenital malformation neonatal outcome newborn preterm sex difference |
| title | Congenital Malformations in the Newborn Population: A Population Study and Analysis of the Effect of Sex and Prematurity |
| title_full | Congenital Malformations in the Newborn Population: A Population Study and Analysis of the Effect of Sex and Prematurity |
| title_fullStr | Congenital Malformations in the Newborn Population: A Population Study and Analysis of the Effect of Sex and Prematurity |
| title_full_unstemmed | Congenital Malformations in the Newborn Population: A Population Study and Analysis of the Effect of Sex and Prematurity |
| title_short | Congenital Malformations in the Newborn Population: A Population Study and Analysis of the Effect of Sex and Prematurity |
| title_sort | congenital malformations in the newborn population a population study and analysis of the effect of sex and prematurity |
| topic | congenital malformation neonatal outcome newborn preterm sex difference |
| url | http://www.sciencedirect.com/science/article/pii/S1875957214001326 |
| work_keys_str_mv | AT alexanderegbe congenitalmalformationsinthenewbornpopulationapopulationstudyandanalysisoftheeffectofsexandprematurity AT santoshuppu congenitalmalformationsinthenewbornpopulationapopulationstudyandanalysisoftheeffectofsexandprematurity AT simonlee congenitalmalformationsinthenewbornpopulationapopulationstudyandanalysisoftheeffectofsexandprematurity AT annemariestroustrup congenitalmalformationsinthenewbornpopulationapopulationstudyandanalysisoftheeffectofsexandprematurity AT deborahho congenitalmalformationsinthenewbornpopulationapopulationstudyandanalysisoftheeffectofsexandprematurity AT shubhikasrivastava congenitalmalformationsinthenewbornpopulationapopulationstudyandanalysisoftheeffectofsexandprematurity |