Prognostic value of serum NLR, PLR, P53, K67 level in lymph node metastasis of early gastric cancer
Background: To explore the predictive value of relevant detection indexes and pathological serum NLR, PLR, P53, and K67 levels in lymph node metastasis (LNM) in patients with early gastric cancer (EGC) after radical surgery. Methods: Clinical data of EGC patients (297 cases, all of whom underwent ra...
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Society of Medical Biochemists of Serbia, Belgrade
2025-01-01
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| Series: | Journal of Medical Biochemistry |
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| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2025/1452-82582504792L.pdf |
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| author | Long Xin Shi Yingxi Li Feifei Wang Zhaojun Wang Ying |
| author_facet | Long Xin Shi Yingxi Li Feifei Wang Zhaojun Wang Ying |
| author_sort | Long Xin |
| collection | DOAJ |
| description | Background: To explore the predictive value of relevant detection indexes and pathological serum NLR, PLR, P53, and K67 levels in lymph node metastasis (LNM) in patients with early gastric cancer (EGC) after radical surgery. Methods: Clinical data of EGC patients (297 cases, all of whom underwent radical gastrectomy for gastric cancer) admitted to Sichuan Integrative Medicine Hospital from March 2019 to March 2024 were retrospectively included. The clinical data and pathological results were recorded and compared, and the related predictive factors were analysed. Results: There were 43 cases (14.48%) of postoperative LNM among the 297 EGC patients. The average number of lymph nodes detected in the LNM (-) group was 28.35 ± 8.23, which was lower than in the LNM (+) group (33 ± 15), *P* < 0.01. Binary multivariate logistic regression analysis identified the following as significant predictors of postoperative LNM in EGC patients: tumour size (OR: 2.582, 95% CI: 1.205-5.534), depth of invasion (OR: 2.953, 95% CI: 1.327-6.573), vascular invasion (OR: 2.724, 95% CI: 1.241-5.976), neuroaggression (OR: 2.681, 95% CI: 1.139-6.311), differentiation type (OR: 2.426, 95% CI: 1.140-5.119), and P53 (OR: 3.133, 95% CI: 1.183-8.301), P<0.05. The area under the ROC curve (AUC) for the model based on these indexes was 0.801. Compared with the LNM (-) group, the LNM (+) group had a lower overall survival rate at 1 and 2 years (P<0.05). Conclusions: Clinically relevant detection indexes and pathological P53 levels in patients after EGC radical surgery have a good predictive effect on the occurrence of LNM, which can assist in formulating scientific and reasonable clinical treatment plans. |
| format | Article |
| id | doaj-art-e267fede8ca84affb13fa339bcc6386f |
| institution | Kabale University |
| issn | 1452-8258 1452-8266 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Society of Medical Biochemists of Serbia, Belgrade |
| record_format | Article |
| series | Journal of Medical Biochemistry |
| spelling | doaj-art-e267fede8ca84affb13fa339bcc6386f2025-08-20T03:29:44ZengSociety of Medical Biochemists of Serbia, BelgradeJournal of Medical Biochemistry1452-82581452-82662025-01-0144479280010.5937/jomb0-556341452-82582504792LPrognostic value of serum NLR, PLR, P53, K67 level in lymph node metastasis of early gastric cancerLong Xin0Shi Yingxi1Li Feifei2Wang Zhaojun3Wang Ying4Sichuan Integrative Medicine Hospital, Department of Medical Oncology, Chengdu, ChinaSichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine UESTC, Oncology Center, Chengdu, ChinaSichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine UESTC, Oncology Center, Chengdu, ChinaDazhou Integrated TCM & Western Medicine Hospital, Department of Medical Oncology, Chengdu, ChinaSichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine UESTC, Oncology Center, Chengdu, ChinaBackground: To explore the predictive value of relevant detection indexes and pathological serum NLR, PLR, P53, and K67 levels in lymph node metastasis (LNM) in patients with early gastric cancer (EGC) after radical surgery. Methods: Clinical data of EGC patients (297 cases, all of whom underwent radical gastrectomy for gastric cancer) admitted to Sichuan Integrative Medicine Hospital from March 2019 to March 2024 were retrospectively included. The clinical data and pathological results were recorded and compared, and the related predictive factors were analysed. Results: There were 43 cases (14.48%) of postoperative LNM among the 297 EGC patients. The average number of lymph nodes detected in the LNM (-) group was 28.35 ± 8.23, which was lower than in the LNM (+) group (33 ± 15), *P* < 0.01. Binary multivariate logistic regression analysis identified the following as significant predictors of postoperative LNM in EGC patients: tumour size (OR: 2.582, 95% CI: 1.205-5.534), depth of invasion (OR: 2.953, 95% CI: 1.327-6.573), vascular invasion (OR: 2.724, 95% CI: 1.241-5.976), neuroaggression (OR: 2.681, 95% CI: 1.139-6.311), differentiation type (OR: 2.426, 95% CI: 1.140-5.119), and P53 (OR: 3.133, 95% CI: 1.183-8.301), P<0.05. The area under the ROC curve (AUC) for the model based on these indexes was 0.801. Compared with the LNM (-) group, the LNM (+) group had a lower overall survival rate at 1 and 2 years (P<0.05). Conclusions: Clinically relevant detection indexes and pathological P53 levels in patients after EGC radical surgery have a good predictive effect on the occurrence of LNM, which can assist in formulating scientific and reasonable clinical treatment plans.https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2025/1452-82582504792L.pdfserum nlrplrp53k67early gastric cancerpathological featureslymph node metastasisrisk factors |
| spellingShingle | Long Xin Shi Yingxi Li Feifei Wang Zhaojun Wang Ying Prognostic value of serum NLR, PLR, P53, K67 level in lymph node metastasis of early gastric cancer Journal of Medical Biochemistry serum nlr plr p53 k67 early gastric cancer pathological features lymph node metastasis risk factors |
| title | Prognostic value of serum NLR, PLR, P53, K67 level in lymph node metastasis of early gastric cancer |
| title_full | Prognostic value of serum NLR, PLR, P53, K67 level in lymph node metastasis of early gastric cancer |
| title_fullStr | Prognostic value of serum NLR, PLR, P53, K67 level in lymph node metastasis of early gastric cancer |
| title_full_unstemmed | Prognostic value of serum NLR, PLR, P53, K67 level in lymph node metastasis of early gastric cancer |
| title_short | Prognostic value of serum NLR, PLR, P53, K67 level in lymph node metastasis of early gastric cancer |
| title_sort | prognostic value of serum nlr plr p53 k67 level in lymph node metastasis of early gastric cancer |
| topic | serum nlr plr p53 k67 early gastric cancer pathological features lymph node metastasis risk factors |
| url | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2025/1452-82582504792L.pdf |
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