Monoclonal gammopathy of undetermined significance with associated necrotizing myopathy: a case report and review of the literature
Background: Monoclonal gammopathies encompass many types of plasma cell proliferative disorders ranging from benign to malignant. Monoclonal gammopathies that meet diagnostic criteria for monoclonal gammopathies of undetermined significance (MGUS) but with clinical manifestations are now being refer...
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| Language: | English |
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SMC MEDIA SRL
2025-04-01
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| Series: | European Journal of Case Reports in Internal Medicine |
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| Online Access: | https://www.ejcrim.com/index.php/EJCRIM/article/view/5229 |
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| author | Anna Bode Oscar Borja Montes Karen SantaCruz Abu Baker Sheikh |
| author_facet | Anna Bode Oscar Borja Montes Karen SantaCruz Abu Baker Sheikh |
| author_sort | Anna Bode |
| collection | DOAJ |
| description | Background: Monoclonal gammopathies encompass many types of plasma cell proliferative disorders ranging from benign to malignant. Monoclonal gammopathies that meet diagnostic criteria for monoclonal gammopathies of undetermined significance (MGUS) but with clinical manifestations are now being referred to as monoclonal gammopathies of clinical significance (MGCS). MGUS associated myopathies are a rare form of MGCS.
Case description: We present a case of MGUS associated necrotizing myositis. The patient had been previously diagnosed with MGUS and myositis around the same time, but prior testing had not revealed the etiology of the myopathy. Repeat biopsy and work-up revealed a necrotizing myopathy.
Discussion: MGUS associated myopathies are rare, with the most common being sporadic late-onset nemaline myopathy (SLONM-MGUS) and amyloid light chain (AL) amyloidosis-associated myopathy. MGUS associated necrotizing myopathy is even rarer. Because this condition is so uncommon, there are no standardized guidelines on how to treat this condition. Some case reports or studies suggest treating the myositis with standard of care for the myositis type without considering the monoclonal gammopathy while other studies have suggested that treating the monoclonal gammopathy would be beneficial in treating the associated clinical syndrome.
Conclusion: Our case report of MGUS associated necrotizing myopathy encourages internists to broaden their differential diagnosis of myopathy, increasing awareness of a condition that is still not well understood. |
| format | Article |
| id | doaj-art-e267ed6aa5ed478f962d6aa83376e171 |
| institution | OA Journals |
| issn | 2284-2594 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | SMC MEDIA SRL |
| record_format | Article |
| series | European Journal of Case Reports in Internal Medicine |
| spelling | doaj-art-e267ed6aa5ed478f962d6aa83376e1712025-08-20T02:13:56ZengSMC MEDIA SRLEuropean Journal of Case Reports in Internal Medicine2284-25942025-04-0110.12890/2025_0052294764Monoclonal gammopathy of undetermined significance with associated necrotizing myopathy: a case report and review of the literatureAnna Bode0Oscar Borja Montes1Karen SantaCruz2Abu Baker Sheikh3Department of Internal Medicine, University of New Mexico, Albuquerque, USADepartment of Internal Medicine, University of New Mexico, Albuquerque, USADepartment of Pathology, University of New Mexico, Albuquerque, USADepartment of Internal Medicine, University of New Mexico, Albuquerque, USABackground: Monoclonal gammopathies encompass many types of plasma cell proliferative disorders ranging from benign to malignant. Monoclonal gammopathies that meet diagnostic criteria for monoclonal gammopathies of undetermined significance (MGUS) but with clinical manifestations are now being referred to as monoclonal gammopathies of clinical significance (MGCS). MGUS associated myopathies are a rare form of MGCS. Case description: We present a case of MGUS associated necrotizing myositis. The patient had been previously diagnosed with MGUS and myositis around the same time, but prior testing had not revealed the etiology of the myopathy. Repeat biopsy and work-up revealed a necrotizing myopathy. Discussion: MGUS associated myopathies are rare, with the most common being sporadic late-onset nemaline myopathy (SLONM-MGUS) and amyloid light chain (AL) amyloidosis-associated myopathy. MGUS associated necrotizing myopathy is even rarer. Because this condition is so uncommon, there are no standardized guidelines on how to treat this condition. Some case reports or studies suggest treating the myositis with standard of care for the myositis type without considering the monoclonal gammopathy while other studies have suggested that treating the monoclonal gammopathy would be beneficial in treating the associated clinical syndrome. Conclusion: Our case report of MGUS associated necrotizing myopathy encourages internists to broaden their differential diagnosis of myopathy, increasing awareness of a condition that is still not well understood.https://www.ejcrim.com/index.php/EJCRIM/article/view/5229monoclonal gammopathymyopathy |
| spellingShingle | Anna Bode Oscar Borja Montes Karen SantaCruz Abu Baker Sheikh Monoclonal gammopathy of undetermined significance with associated necrotizing myopathy: a case report and review of the literature European Journal of Case Reports in Internal Medicine monoclonal gammopathy myopathy |
| title | Monoclonal gammopathy of undetermined significance with associated necrotizing myopathy: a case report and review of the literature |
| title_full | Monoclonal gammopathy of undetermined significance with associated necrotizing myopathy: a case report and review of the literature |
| title_fullStr | Monoclonal gammopathy of undetermined significance with associated necrotizing myopathy: a case report and review of the literature |
| title_full_unstemmed | Monoclonal gammopathy of undetermined significance with associated necrotizing myopathy: a case report and review of the literature |
| title_short | Monoclonal gammopathy of undetermined significance with associated necrotizing myopathy: a case report and review of the literature |
| title_sort | monoclonal gammopathy of undetermined significance with associated necrotizing myopathy a case report and review of the literature |
| topic | monoclonal gammopathy myopathy |
| url | https://www.ejcrim.com/index.php/EJCRIM/article/view/5229 |
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