Photodynamic therapy of Bowen’s disease
Bowen’s disease is a form of non-invasive (in situ) squamous cell skin cancer localized in the non-genital area. Russian and European clinical guidelines include photodynamic therapy (PDT) in the standard of care for patients with Bowen’s disease. In the present review, the efficacy and safety profi...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Non-profit partnership for development of domestic photodynamic therapy and photodiagnosis "Russian Photodynamic Association"
2024-03-01
|
| Series: | Biomedical Photonics |
| Subjects: | |
| Online Access: | https://www.pdt-journal.com/jour/article/view/622 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849241292235603968 |
|---|---|
| author | E. V. Filonenko V. I. Ivanova-Radkevich |
| author_facet | E. V. Filonenko V. I. Ivanova-Radkevich |
| author_sort | E. V. Filonenko |
| collection | DOAJ |
| description | Bowen’s disease is a form of non-invasive (in situ) squamous cell skin cancer localized in the non-genital area. Russian and European clinical guidelines include photodynamic therapy (PDT) in the standard of care for patients with Bowen’s disease. In the present review, the efficacy and safety profile of different PDT regimens for Bowen’s disease are analyzed according to the available literature data. PDT can be used to treat large Bowen’s disease lesions localized in areas of the body characterized by severe healing and in cases where surgery is not feasible. Analysis of the results of studies shows that PDT is superior in efficacy and cosmetic results to traditional local treatments such as 5-fluorouracil or cryotherapy. In all analyzed studies in patients with Bowen’s disease, PDT achieved a significant clinical effect. Complete regression of pathologic foci was achieved in 67-100% of patients. In studies evaluating the recurrence rate of Bowen’s disease after PDT, this value ranged from 2-28% with the range of 6-18% in most of the studies. Most often, 5-aminolevulinic acid and its methyl ester are used for PDT in Bowen’s disease. According to some researchers, aminolevulinic acid allows to achieve a more long-term positive clinical effect with a lower incidence of painful reactions during treatment |
| format | Article |
| id | doaj-art-e2617fc7639d460192e76195e941553c |
| institution | Kabale University |
| issn | 2413-9432 |
| language | Russian |
| publishDate | 2024-03-01 |
| publisher | Non-profit partnership for development of domestic photodynamic therapy and photodiagnosis "Russian Photodynamic Association" |
| record_format | Article |
| series | Biomedical Photonics |
| spelling | doaj-art-e2617fc7639d460192e76195e941553c2025-08-20T04:00:13ZrusNon-profit partnership for development of domestic photodynamic therapy and photodiagnosis "Russian Photodynamic Association"Biomedical Photonics2413-94322024-03-01124222910.24931/2413-9432-2023-12-4-22-29285Photodynamic therapy of Bowen’s diseaseE. V. Filonenko0V. I. Ivanova-Radkevich1P.A. Herzen Moscow Oncology Research Center – branch of FSBI NMRRC of the Ministry of Health of the Russian FederationPeoples’ Friendship University of Russia (RUDN University)Bowen’s disease is a form of non-invasive (in situ) squamous cell skin cancer localized in the non-genital area. Russian and European clinical guidelines include photodynamic therapy (PDT) in the standard of care for patients with Bowen’s disease. In the present review, the efficacy and safety profile of different PDT regimens for Bowen’s disease are analyzed according to the available literature data. PDT can be used to treat large Bowen’s disease lesions localized in areas of the body characterized by severe healing and in cases where surgery is not feasible. Analysis of the results of studies shows that PDT is superior in efficacy and cosmetic results to traditional local treatments such as 5-fluorouracil or cryotherapy. In all analyzed studies in patients with Bowen’s disease, PDT achieved a significant clinical effect. Complete regression of pathologic foci was achieved in 67-100% of patients. In studies evaluating the recurrence rate of Bowen’s disease after PDT, this value ranged from 2-28% with the range of 6-18% in most of the studies. Most often, 5-aminolevulinic acid and its methyl ester are used for PDT in Bowen’s disease. According to some researchers, aminolevulinic acid allows to achieve a more long-term positive clinical effect with a lower incidence of painful reactions during treatmenthttps://www.pdt-journal.com/jour/article/view/622photodynamic therapybowen’s disease5-aminolevulinic acid5-aminolevulinic acid methyl ester |
| spellingShingle | E. V. Filonenko V. I. Ivanova-Radkevich Photodynamic therapy of Bowen’s disease Biomedical Photonics photodynamic therapy bowen’s disease 5-aminolevulinic acid 5-aminolevulinic acid methyl ester |
| title | Photodynamic therapy of Bowen’s disease |
| title_full | Photodynamic therapy of Bowen’s disease |
| title_fullStr | Photodynamic therapy of Bowen’s disease |
| title_full_unstemmed | Photodynamic therapy of Bowen’s disease |
| title_short | Photodynamic therapy of Bowen’s disease |
| title_sort | photodynamic therapy of bowen s disease |
| topic | photodynamic therapy bowen’s disease 5-aminolevulinic acid 5-aminolevulinic acid methyl ester |
| url | https://www.pdt-journal.com/jour/article/view/622 |
| work_keys_str_mv | AT evfilonenko photodynamictherapyofbowensdisease AT viivanovaradkevich photodynamictherapyofbowensdisease |