Dynamic OGTT-derived C-peptide trajectories for metabolic heterogeneity and adverse pregnancy outcomes in gestational diabetes mellitus: a nested case‒control study

Dynamic OGTT-derived C-peptide trajectories for metabolic heterogeneity and adverse pregnancy outcomes in gestational diabetes mellitus: a nested case‒control study

Abstract Background Existing diagnostic criteria for gestational diabetes mellitus (GDM) rely solely on glucose thresholds, which are insufficient to capture metabolic heterogeneity. We aimed to evaluate the role of C-peptide measured during the oral glucose tolerance test (OGTT) in assisting the de...

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Bibliographic Details
Main Authors: Xinyue Wang, Zhangya He, Jing Ji, Simin Zhang, Jinglin Li, Jiahui Zhang, Wenlu Yu, Hexiang Yang, Zhen Han, Yang Mi, Xiaoqin Luo
Format: Article
Language:English
Published: BMC 2025-08-01
Series:BMC Medicine
Subjects:
Gestational diabetes mellitus
C-peptide
Latent class trajectory analysis
Beta-cell function
Insulin resistance
Online Access:https://doi.org/10.1186/s12916-025-04281-x
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