The distinct effects of metformin and imeglimin on high glucose-induced alterations in metabolic function and reactive oxygen species production in mouse Schwann cells are modulated by pemafibrate and/or fatty acid-binding proteins.

The distinct effects of metformin and imeglimin on high glucose-induced alterations in metabolic function and reactive oxygen species production in mouse Schwann cells are modulated by pemafibrate and/or fatty acid-binding proteins.

BackgroundImeglimin (Ime), the first in a novel class of antidiabetic agents, has potential therapeutic effects on diabetic peripheral neuropathy (DPN). This study aimed to evaluate and compare the effects on cellular metabolic function and reactive oxygen species (ROS) levels in high glucose-treate...

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Bibliographic Details
Main Authors: Hiroshi Ohguro, Megumi Higashide, Nami Nishikiori, Toshifumi Ogawa, Masato Furuhashi, Tatsuya Sato, Megumi Watanabe
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Schwann cells
metformin
imeglimin
FABP5
FABP7
extracellular flux analyzer
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2025.1634262/full
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