The potential of chimeric antigen receptor -T cell therapy for endocrine cancer
Abstract Endocrine cancer, a relatively rare and heterogeneous tumor with diverse clinical features. The facile synthesis of hormones further complicates endocrine cancer treatment. Thus, the development of safe and effective systemic treatment approaches, such as chimeric antigen receptor (CAR) T c...
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| Format: | Article |
| Language: | English |
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BMC
2025-04-01
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| Series: | World Journal of Surgical Oncology |
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| Online Access: | https://doi.org/10.1186/s12957-025-03745-x |
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| _version_ | 1849713109875294208 |
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| author | Ruonan Yu Xiaoyu Ji Ping Zhang Hao Zhang Huiling Qu Wenwu Dong |
| author_facet | Ruonan Yu Xiaoyu Ji Ping Zhang Hao Zhang Huiling Qu Wenwu Dong |
| author_sort | Ruonan Yu |
| collection | DOAJ |
| description | Abstract Endocrine cancer, a relatively rare and heterogeneous tumor with diverse clinical features. The facile synthesis of hormones further complicates endocrine cancer treatment. Thus, the development of safe and effective systemic treatment approaches, such as chimeric antigen receptor (CAR) T cell therapy, is imperative to enhance the prognosis of patients with endocrine cancer. Although this therapy has achieved good results in the treatment of hematological malignancies, it encounters diverse complications and challenges in the context of endocrine cancer. This review delineates the generation of CAR-T cells, examines the potential of CAR-T cell therapy for endocrine cancer, enumerates pivotal antigens linked to endocrine cancer, encapsulates the challenges confronted with CAR-T cell therapy for endocrine cancer, and expounds upon strategies to overcome these limitations. The primary objective is to provide insightful perspectives that can contribute to the advancement of CAR-T cell therapy in the field of endocrine cancer. |
| format | Article |
| id | doaj-art-e25cb63300e84ea09657d6fafa5b0586 |
| institution | DOAJ |
| issn | 1477-7819 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj-art-e25cb63300e84ea09657d6fafa5b05862025-08-20T03:14:03ZengBMCWorld Journal of Surgical Oncology1477-78192025-04-0123111710.1186/s12957-025-03745-xThe potential of chimeric antigen receptor -T cell therapy for endocrine cancerRuonan Yu0Xiaoyu Ji1Ping Zhang2Hao Zhang3Huiling Qu4Wenwu Dong5Department of Thyroid Surgery, The First Hospital of China Medical UniversityDepartment of Thyroid Surgery, The First Hospital of China Medical UniversityDepartment of Thyroid Surgery, The First Hospital of China Medical UniversityDepartment of Thyroid Surgery, The First Hospital of China Medical UniversityDepartment of Neurology, The General Hospital of Northern Theater CommandDepartment of Thyroid Surgery, The First Hospital of China Medical UniversityAbstract Endocrine cancer, a relatively rare and heterogeneous tumor with diverse clinical features. The facile synthesis of hormones further complicates endocrine cancer treatment. Thus, the development of safe and effective systemic treatment approaches, such as chimeric antigen receptor (CAR) T cell therapy, is imperative to enhance the prognosis of patients with endocrine cancer. Although this therapy has achieved good results in the treatment of hematological malignancies, it encounters diverse complications and challenges in the context of endocrine cancer. This review delineates the generation of CAR-T cells, examines the potential of CAR-T cell therapy for endocrine cancer, enumerates pivotal antigens linked to endocrine cancer, encapsulates the challenges confronted with CAR-T cell therapy for endocrine cancer, and expounds upon strategies to overcome these limitations. The primary objective is to provide insightful perspectives that can contribute to the advancement of CAR-T cell therapy in the field of endocrine cancer.https://doi.org/10.1186/s12957-025-03745-xAntigen targetsCAR-T cellEndocrine cancerImmunotherapyThyroid |
| spellingShingle | Ruonan Yu Xiaoyu Ji Ping Zhang Hao Zhang Huiling Qu Wenwu Dong The potential of chimeric antigen receptor -T cell therapy for endocrine cancer World Journal of Surgical Oncology Antigen targets CAR-T cell Endocrine cancer Immunotherapy Thyroid |
| title | The potential of chimeric antigen receptor -T cell therapy for endocrine cancer |
| title_full | The potential of chimeric antigen receptor -T cell therapy for endocrine cancer |
| title_fullStr | The potential of chimeric antigen receptor -T cell therapy for endocrine cancer |
| title_full_unstemmed | The potential of chimeric antigen receptor -T cell therapy for endocrine cancer |
| title_short | The potential of chimeric antigen receptor -T cell therapy for endocrine cancer |
| title_sort | potential of chimeric antigen receptor t cell therapy for endocrine cancer |
| topic | Antigen targets CAR-T cell Endocrine cancer Immunotherapy Thyroid |
| url | https://doi.org/10.1186/s12957-025-03745-x |
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