Impact of non-coding RNAs on resistance to imatinib in chronic myelogenous leukemia
Imatinib is approved as the first-line treatment for newly diagnosed chronic myelogenous leukemia (CML). In spite of profound response in the majority of patients, resistance occurs in a subgroup of CML cases. Recently, it has been demonstrated that different classes of non-coding RNAs can modulate...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Leukemia Research Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213048925000317 |
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| author | Fatemeh Ensafi Talemi Soudeh Ghafouri-Fard |
| author_facet | Fatemeh Ensafi Talemi Soudeh Ghafouri-Fard |
| author_sort | Fatemeh Ensafi Talemi |
| collection | DOAJ |
| description | Imatinib is approved as the first-line treatment for newly diagnosed chronic myelogenous leukemia (CML). In spite of profound response in the majority of patients, resistance occurs in a subgroup of CML cases. Recently, it has been demonstrated that different classes of non-coding RNAs can modulate response to this tyrosine kinase inhibitor. Recognition of the role of these transcripts in this process not only expands our knowledge about the molecular mechanisms of imatinib resistance, but also provides novel strategies for combating this phenotype. The current review summarizes the role of non-coding RNAs in this process and suggests novel candidates for further studies in this field to enhance therapeutic response to imatinib. |
| format | Article |
| id | doaj-art-e259e889e4d040b6a90809b4c3ccf16a |
| institution | Kabale University |
| issn | 2213-0489 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Leukemia Research Reports |
| spelling | doaj-art-e259e889e4d040b6a90809b4c3ccf16a2025-08-20T03:34:19ZengElsevierLeukemia Research Reports2213-04892025-01-012410052910.1016/j.lrr.2025.100529Impact of non-coding RNAs on resistance to imatinib in chronic myelogenous leukemiaFatemeh Ensafi Talemi0Soudeh Ghafouri-Fard1Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Corresponding author.Imatinib is approved as the first-line treatment for newly diagnosed chronic myelogenous leukemia (CML). In spite of profound response in the majority of patients, resistance occurs in a subgroup of CML cases. Recently, it has been demonstrated that different classes of non-coding RNAs can modulate response to this tyrosine kinase inhibitor. Recognition of the role of these transcripts in this process not only expands our knowledge about the molecular mechanisms of imatinib resistance, but also provides novel strategies for combating this phenotype. The current review summarizes the role of non-coding RNAs in this process and suggests novel candidates for further studies in this field to enhance therapeutic response to imatinib.http://www.sciencedirect.com/science/article/pii/S2213048925000317lncRNAmiRNAcircRNAImatinibChronic myelogenous leukemia |
| spellingShingle | Fatemeh Ensafi Talemi Soudeh Ghafouri-Fard Impact of non-coding RNAs on resistance to imatinib in chronic myelogenous leukemia Leukemia Research Reports lncRNA miRNA circRNA Imatinib Chronic myelogenous leukemia |
| title | Impact of non-coding RNAs on resistance to imatinib in chronic myelogenous leukemia |
| title_full | Impact of non-coding RNAs on resistance to imatinib in chronic myelogenous leukemia |
| title_fullStr | Impact of non-coding RNAs on resistance to imatinib in chronic myelogenous leukemia |
| title_full_unstemmed | Impact of non-coding RNAs on resistance to imatinib in chronic myelogenous leukemia |
| title_short | Impact of non-coding RNAs on resistance to imatinib in chronic myelogenous leukemia |
| title_sort | impact of non coding rnas on resistance to imatinib in chronic myelogenous leukemia |
| topic | lncRNA miRNA circRNA Imatinib Chronic myelogenous leukemia |
| url | http://www.sciencedirect.com/science/article/pii/S2213048925000317 |
| work_keys_str_mv | AT fatemehensafitalemi impactofnoncodingrnasonresistancetoimatinibinchronicmyelogenousleukemia AT soudehghafourifard impactofnoncodingrnasonresistancetoimatinibinchronicmyelogenousleukemia |