Exploring the dynamic pathogenesis of Parkinson's disease by case-control and longitudinal blood transcriptome analyses
The pathogenesis of Parkinson's disease (PD) was recently hypothesized to change along with the disease course. Given the fact that transcriptional changes in blood can provide insightful clues for PD pathogenesis, we performed case-control and longitudinal whole blood transcriptome analyses to...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | Neurobiology of Disease |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S096999612500107X |
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| author | Gang Xue Gang Wang Qianqian Shi Hui Wang Bo-Min Lv Min Gao Xiaohui Niu Hong-Yu Zhang |
| author_facet | Gang Xue Gang Wang Qianqian Shi Hui Wang Bo-Min Lv Min Gao Xiaohui Niu Hong-Yu Zhang |
| author_sort | Gang Xue |
| collection | DOAJ |
| description | The pathogenesis of Parkinson's disease (PD) was recently hypothesized to change along with the disease course. Given the fact that transcriptional changes in blood can provide insightful clues for PD pathogenesis, we performed case-control and longitudinal whole blood transcriptome analyses to identify the signature genes underlying the hypothesized dynamic pathogenesis of PD. In the case-control study, we compared the gene expression patterns in healthy control (N = 189), prodromal (N = 58) and de novo idiopathic PD subjects (N = 390). The results showed that the prodromal subjects were at the tipping-point stage, which is characterized by the abnormal expression patterns of 414 genes associated with oxygen transport and reactive oxygen species metabolic process. We next performed a longitudinal transcriptome analysis on 255 PD patients from the baseline to the third year, and identified 203 genes related to immune and inflammatory responses during disease progression. These findings not just offer deeper insights into the dynamic pathogenesis of PD, but also help to find potential drugs to prevent the early neurodegeneration process. |
| format | Article |
| id | doaj-art-e24fc23c933e4068a658494c18b47134 |
| institution | OA Journals |
| issn | 1095-953X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Disease |
| spelling | doaj-art-e24fc23c933e4068a658494c18b471342025-08-20T02:24:55ZengElsevierNeurobiology of Disease1095-953X2025-06-0120910689110.1016/j.nbd.2025.106891Exploring the dynamic pathogenesis of Parkinson's disease by case-control and longitudinal blood transcriptome analysesGang Xue0Gang Wang1Qianqian Shi2Hui Wang3Bo-Min Lv4Min Gao5Xiaohui Niu6Hong-Yu Zhang7Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University, Wuhan 430070, ChinaHubei Key Laboratory of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University, Wuhan 430070, China; Basic Medical Laboratory, Hubei Key Laboratory of Central Nervous System Tumor and Intervention, General Hospital of Central Theater Command, Wuhan, Hubei Province 430070, ChinaHubei Key Laboratory of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University, Wuhan 430070, ChinaHubei Key Laboratory of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University, Wuhan 430070, ChinaHubei Key Laboratory of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University, Wuhan 430070, ChinaHubei Key Laboratory of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University, Wuhan 430070, China; Lab of Epigenetics and Advanced Health Technology, Space Science and Technology Institute (Shenzhen), Shenzhen 518117, ChinaHubei Key Laboratory of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University, Wuhan 430070, China; Corresponding authors.Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University, Wuhan 430070, China; Corresponding authors.The pathogenesis of Parkinson's disease (PD) was recently hypothesized to change along with the disease course. Given the fact that transcriptional changes in blood can provide insightful clues for PD pathogenesis, we performed case-control and longitudinal whole blood transcriptome analyses to identify the signature genes underlying the hypothesized dynamic pathogenesis of PD. In the case-control study, we compared the gene expression patterns in healthy control (N = 189), prodromal (N = 58) and de novo idiopathic PD subjects (N = 390). The results showed that the prodromal subjects were at the tipping-point stage, which is characterized by the abnormal expression patterns of 414 genes associated with oxygen transport and reactive oxygen species metabolic process. We next performed a longitudinal transcriptome analysis on 255 PD patients from the baseline to the third year, and identified 203 genes related to immune and inflammatory responses during disease progression. These findings not just offer deeper insights into the dynamic pathogenesis of PD, but also help to find potential drugs to prevent the early neurodegeneration process.http://www.sciencedirect.com/science/article/pii/S096999612500107XParkinson's diseaseDynamicPathogenesisBlood transcriptome |
| spellingShingle | Gang Xue Gang Wang Qianqian Shi Hui Wang Bo-Min Lv Min Gao Xiaohui Niu Hong-Yu Zhang Exploring the dynamic pathogenesis of Parkinson's disease by case-control and longitudinal blood transcriptome analyses Neurobiology of Disease Parkinson's disease Dynamic Pathogenesis Blood transcriptome |
| title | Exploring the dynamic pathogenesis of Parkinson's disease by case-control and longitudinal blood transcriptome analyses |
| title_full | Exploring the dynamic pathogenesis of Parkinson's disease by case-control and longitudinal blood transcriptome analyses |
| title_fullStr | Exploring the dynamic pathogenesis of Parkinson's disease by case-control and longitudinal blood transcriptome analyses |
| title_full_unstemmed | Exploring the dynamic pathogenesis of Parkinson's disease by case-control and longitudinal blood transcriptome analyses |
| title_short | Exploring the dynamic pathogenesis of Parkinson's disease by case-control and longitudinal blood transcriptome analyses |
| title_sort | exploring the dynamic pathogenesis of parkinson s disease by case control and longitudinal blood transcriptome analyses |
| topic | Parkinson's disease Dynamic Pathogenesis Blood transcriptome |
| url | http://www.sciencedirect.com/science/article/pii/S096999612500107X |
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